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A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age
Date:7/14/2009

ta from The Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994). They identified 1,799 men and women age 60 and older who had data on levels of aerobic-related physical activity (AR-PA), such as walking, jogging, bicycling or swimming; mental status test scores; and APOE genotype.

In their analysis, the researchers found that physical activity was associated with enhanced cognitive function, and that this relationship was differentially influenced by the person's APOE genotype: non-E4 carriers and people with one copy of E4 performed better than people with two copies of E4. After adjusting for age, ethnicity, severe chronic medical illness, lean body mass, and education, aerobic physical activity continued to show a statistically significant association with cognitive function in non-E4 carriers but not in people with E4 (any combination)

"In our nationally representative sample, persons who reported higher levels of aerobic physical activity had better memory than those who reported no such activity. This was especially true in those people who didn't have the APOE-e4 Alzheimer's risk gene," Obisesan said.

"Because physical activity is a low-cost, low-risk, readily available intervention, it may prove to be an important public health strategy to reduce or prevent memory loss and other symptoms of mental decline in the elderly. Future rigorous clinical trials are needed to confirm these findings," Obisesan added.

About ICAD 2009

The 2009 Alzheimer's Association International Conference on Alzheimer's Disease (ICAD 2009) brings together more than 3,000 researchers from 70 countries to share groundbreaking research and information on the cause, diagnosis, treatment and prevention of Alzheimer's disease and related disorders. As a part of the Association's research program, ICAD 2009 serves as a catalyst for generating new knowledge
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SOURCE Alzheimer's Association
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