Navigation Links
A Finnish-Swiss team cracks the atomic structure of a major cancer drug target
Date:1/19/2010

Researchers at the University of Helsinki, Finland, and the Paul Scherrer Institute (PSI) in Villigen, Switzerland, have determined the crystal structure of the ligand binding domain of a vascular endothelial growth factor (VEGF) receptor in complex with one of its ligands (VEGF-C).

Cancer cells require access to blood and lymph vessels for invasive growth and metastasis. By releasing VEGFs, cancer cells stimulate the surrounding blood vessels to invade the cancerous tumor mass. Blocking this process is a new strategy to inhibit tumor growth.

VEGFs and their receptors have been identified as major targets for drug development in cancer therapy and the VEGF receptor that the groups analyzed is currently the most important target of such drugs. The Finnish group discovered the VEGF-C growth factor in 1996 and found that it is involved in lymphatic vessel growth, cancer metastasis and, more recently, also in blood vessel growth in cancer.

The collaborative work published in PNAS by the two research teams provides significant new insights into VEGF receptor function. It was also made possible by the long-standing interest and collaborative research of the binational team and the availability of excellent crystallography beamlines at the Swiss Synchrotron Light Source located at PSI, and supported by the European Union.


'/>"/>

Contact: Kari Alitalo
kari.alitalo@helsinki.fi
358-919-125-511
University of Helsinki
Source:Eurekalert  

Page: 1

Related medicine news :

1. New York City Cracks Down on Pedicabs
2. Dr. Siegal's Cookie Diet Book by Obesity Expert Sanford Siegal, D.O., M.D, Cracks Amazon Top 500
3. Dr. Siegals Cookie Diet Book Cracks the Amazon Top 500
4. International team cracks mammalian gene control code
5. National Council on Disability Says Older Youth With Disabilities Falling Through Cracks in Foster Care System
6. Depression screening for cancer patients too often falls between the cracks
7. FDA Cracks Down on Unapproved Cough Medicines
8. An atomic-level look at an HIV accomplice
9. Atomic Tattoos Announces "Tats for Tatas" October Fundraising Event to Benefit Local Breast Cancer Research
10. BODY WORLDS Anatomical Exhibitions of Donor Bodies Receives 28 Millionth Visitor.
11. Ancient fossils shed light on anatomical changes accompanying evolution of first land vertebrates
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A Finnish-Swiss team cracks the atomic structure of a major cancer drug target
(Date:9/26/2017)... ... ... The 2017 American Academy of Cosmetic Surgery World Congress on Liposuction meeting ... latest about cosmetic procedures to remove and replace fat, but also how stem cells ... is magical, especially when it comes to the cosmetic patient,” says cosmetic surgeon Dr. ...
(Date:9/26/2017)... ... ... Millennium”: a gripping take on how the author used personal experience to strengthen the ... do not affect daily choices. It shows how to act like the heirs of ... chosen. “How to Live in the Millennium” is the creation of published author, Gina ...
(Date:9/26/2017)... ... ... of My Song”: an intriguing and thought-provoking on love, life, and depression. “Sound of ... a passion for music and ancestral history. , Published by Christian Faith Publishing, ... depression, and finding love through the journey. There is powerful imagery in the poems ...
(Date:9/26/2017)... , ... September 26, 2017 , ... “The Tour Guide”: is the life story of ... the creation of published author, David Alexander Stark, is an adventure tour guide and the ... circled around to the back to confront fifteen shocked faces. I played it off as ...
(Date:9/26/2017)... ... 2017 , ... Time out for Daddy is a moving story of a ... grownups make mistakes. “Time Out for Daddy” is the creation of published author Debra ... whose passion for children inspired her to write this book. , Published by Christian ...
Breaking Medicine News(10 mins):
(Date:9/9/2017)... 8, 2017 Dealmed Medical Supplies, ... medical equipment, supplies, drugs, vaccines, and specialty medical products ... an agreement to acquire Vantage Medical Supplies, a major ... Holtsville, New York . ... and emerging medical practices, will operate under the Dealmed ...
(Date:9/7/2017)... , Sept. 7, 2017  Eli Lilly ... announced actions to streamline operations to more efficiently ... improve its cost structure. Global workforce reductions, including ... are expected to impact approximately 3,500 positions. ... company expects annualized savings of approximately $500 million ...
(Date:9/7/2017)... , Sept. 7, 2017 Caris ... focused on fulfilling the promise of precision medicine, ... validate the benefits of its molecular profiling approach ... utilized comprehensive genomic profiling plus (CGP+) with Caris ... patient,s tumor on a molecular level, leading to ...
Breaking Medicine Technology: