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A Drug With Efficacy Superior to That of Memantine Would Earn up to a 50% Patient Share in the Moderate-to-Severe Alzheimer's Disease Drug Market
Date:3/6/2008

A Drug's Effect on Cognitive Decline is the Most Important Attribute Influencing Prescribing Decisions, According to a New Report from Decision

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WALTHAM, Mass., March 6 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms focusing on pharmaceutical and healthcare issues, finds that a drug with efficacy superior to that of sales leader memantine would earn up to a 50% patient share in the market to treat moderate-to-severe Alzheimer's disease. The currently available branded versions of memantine are Forest Laboratories' Namenda, Lundbeck's Ebixa and Merz/Grupo Grunenthal's Axura/Akatinol.

The new report entitled Alzheimer's Disease (Moderate to Severe): Incremental Improvements in Efficacy Can Lead to Large Commercial Opportunity finds that a symptomatic therapy with efficacy greater than that of memantine, as measured by the Severe Impairment Battery score at 28 weeks, would earn a patient share of 40-50% in the moderate-to-severe Alzheimer's disease market, according to surveyed neurologists. In addition to replacing memantine in most cases, physicians believe that, if such a therapy were launched, it would threaten a significant percentage of prescriptions of donepezil (Eisai/Pfizer's Aricept and Bracco's Memac) and the memantine/donepezil combination.

The report also finds that a therapy's effect on cognitive decline is the attribute that most influences the prescribing decisions of neurologists in treating moderate-to-severe Alzheimer's disease. Clinical data and interviewed experts indicate that Myriad Genetics' Flurizan, Elan/Wyeth's bapineuzumab, Medivation's Dimebon and Eli Lilly's LY-450139 all have advantages over sales- leading memantine on this attribute.

"Some agents, including Flurizan and bapineuzumab, will be used in combination with existing drugs rather than replacing them," said Nitasha Manchanda, Ph.D., analyst at Decision Resour
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SOURCE Decision Resources
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