Navigation Links
A Drug-Dispensing Contact Lens
Date:7/21/2009

Sustained-release could ease treatment of glaucoma and other conditions

BOSTON, July 21 /PRNewswire-USNewswire/ -- Taking eye drops multiple times a day can be difficult for patients to do, and because of blinking and tearing, as little as 1 to 7 percent of the dose is actually absorbed by the eye. Now, researchers led by Daniel Kohane, MD, PhD, director of the Laboratory for Biomaterials and Drug Delivery at Children's Hospital Boston, have developed special contact lenses that can gradually dispense a constant amount of medication to the eye, at adjustable rates. They describe their prototype lens in the July issue of Investigative Ophthalmology and Visual Science.

Although other groups have developed drug-releasing contact lenses, none have been able to achieve a constant, steady release of substantial amounts of drug; typically, a burst of drug is delivered in the first few hours, followed by rapidly dwindling amounts that are too low to be therapeutic. Kohane, collaborator Joseph Ciolino, MD, of the Massachusetts Eye and Ear Infirmary, and colleagues at the Department of Chemical Engineering at the Massachusetts Institute of Technology (MIT) created a two-layer contact lens with an inner drug-bearing biodegradable polymer film known as PLGA. Both PLGA and pHEMA (used for the coating) have been well studied and are already approved for ocular use by the Food and Drug Administration.

In laboratory testing, the prototype lenses dispensed ciprofloxacin (an antibiotic often used in eye drops) for 30 days, the longest duration for which contact lenses are currently approved by the FDA; in some tests, the lenses continued releasing drug for up to 100 days. The amounts dispensed were sufficient to kill pathogens in a laboratory assay.

Kohane and Ciolino see applications in conditions such as glaucoma and dry-eye which require frequent daily ey
'/>"/>

SOURCE Children's Hospital of Boston
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Omnetics' Multi-Contact Nano Connectors Obtain Digital Transmission Rates Over 2 Gb/sec.
2. Can a Contact Lens Cure Nearsightedness? Five-Year Clinical Study Testing Corneal Reshaping Therapy as Possible Method to Arrest Myopia
3. Clearly Contacts Named to BC Business Magazine Top 100 Public Companies List
4. Bausch & Lomb Kicks Off U.S. Consumer Online Marketing Campaign for SofLens(R) Daily Disposable Contact Lenses
5. Girls Overall Self-Worth Improves With Contact Lens Wear, Study Shows
6. Schmidt & Clark, LLP: FDA Reports Show Abbott Labs Subsidiary Failed to Disclose Parasite Eye Infections Tied to Contact Lens Solution
7. Kevin Niksarli, M.D. of Manhattan Lasik Center Reviews Pros and Cons of Contact Lenses vs. iLASIK at an International Meeting on 7/1/2009
8. Clearly Contacts Goes Green With Organic Glasses
9. Clearly Contacts Announces Another Quarter Of Growth In The Economic Downturn
10. VisionDirect.com Offers Contact Lens Customers a New Way to Pay
11. Clearly Contacts Expands Healthy Balance Initiative For Employees
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... 2015 Okyanos, the leader in ... The study was conducted to determine the emotional impact ... and sports-related injuries have had on those affected. ... most prevalent symptom reported at 73%, followed by 66% ... and bending over. Over half of respondents, 56%, said ...
(Date:5/5/2015)... 05, 2015 On April 8th, 2015, ... CA, Choices Recovery sponsored Durkin Entertainment’s “RockNRolla” EcoLuxe Lounge, ... producer of sustainable product placement in TV and film. ... top providers of ecologically sound and socially conscious products ... carpet event that makes appearances at various awards ceremonies ...
(Date:5/5/2015)... Don’t have time to go to the ... Don’t know which workout equipment to use? LiveStreamingFitness.com ... help members achieve their heath and fitness goals and ... caused-based wellness company, today announces the launch of LiveStreamingFitness.com, ... by certified trainers, nutritional information and recipes provided by ...
(Date:5/5/2015)... 2015 Major League Ultimate (MLU) was ... that ultimate Frisbee™ is home to many amazing athletes, ... engages the world. Nike Ultimate Camps’ goal of spreading ... for young athletes to learn about the sport and ... perfect fit. , The Nike Ultimate Camp in Philadelphia ...
(Date:5/5/2015)... May 05, 2015 Igantia , ... Francisco, leads an international initiative to examine key biological ... the human lifespan. Scientists at Igantia believe that ... from the initiation of her menstrual cycle to her ... for aging and, ultimately, extend the lifespan. , ...
Breaking Medicine News(10 mins):Health News:Okyanos Study Finds Orthopedic Patients Plagued with Pain 2Health News:Okyanos Study Finds Orthopedic Patients Plagued with Pain 3Health News:Choices Recovery Mishawaka Talks About Overcoming Adversity with Actor Matthew Ziff at the “RockNRolla Movie Awards” EcoLuxe Lounge 2Health News:Live Streaming Fitness Creates Industry Shift by Bringing Fitness, Nutrition and Cooking Classes to Smart Devices 2Health News:Live Streaming Fitness Creates Industry Shift by Bringing Fitness, Nutrition and Cooking Classes to Smart Devices 3Health News:US Sports Camps, Nike Ultimate Camps, and Major League Ultimate Host Youth Ultimate Summer Camps in Philidelphia 2Health News:Igantia Announces Digital Initiative to Decode Longevity 2
... to other parts of the body could improve understanding ... stroke. Scientists at the University of Edinburgh have ... function of the segment of nerve fibres that controls ... published in the journal Neuron , could help ...
... time however some women experience overwhelming ,baby blues, before the ... result in premature birth, or low birth weight, and impact ... research published in BioMed Central,s open access journal BMC ... husband or partner is the strongest predictor of maternal emotional ...
... SUNDAY, March 13 (HealthDay News) -- With spring allergy ... controlling their allergies, says the American College of Allergy, ... , Over-the-counter (OTC) oral antihistamines are less effective than ... may control some allergy symptoms but have little effect ...
... , FRIDAY, March 11 (HealthDay News) -- People would prefer ... especially if they know others are watching, says a new ... likely to think badly of them if they do something ... to the research in the journal Psychological Science . ...
... 11 (HealthDay News) -- Text messages may help smokers kick ... according to researchers who conducted two studies on 27 heavy ... pinpoint the brain regions most active in controlling urges to ... a series of momentary self-control skirmishes." The study found that ...
... fluids bathing the brain are essential for building the ... in the journal Neuron . The finding promises ... stem cells., Before now, the fluid surrounding the brain ... that simply maintained the brain,s ionic balance. Recent reports ...
Cached Medicine News:Health News:When Someone Is Watching, You're Less Inclined to Do Bad Things 2Health News:Text Messages May Help Smokers Kick the Addiction, Small Study Finds 2Health News:Stem cells take cues from fluid in the brain 2Health News:Stem cells take cues from fluid in the brain 3
(Date:5/5/2015)... , May 5, 2015  Abaxis, Inc. (NasdaqGS: ABAX ... announced today that Clint Severson , chairman and chief ... Lynch 2015 Health Care Conference on Tuesday, May 12, 2015 ... the Encore at the Wynn in Las Vegas, ... worldwide developer, manufacturer and marketer of portable blood analysis systems ...
(Date:5/5/2015)... Mass., May 5, 2015   Cynosure, Inc. ... medical devices for aesthetic procedures and precision surgical applications ... ended March 31, 2015. First-Quarter Highlights: ... , Non-GAAP earnings of $0.15 per share; GAAP ... million at March 31, 2015 "Cynosure delivered ...
(Date:5/5/2015)... , May 5, 2015  Stryker Orthopaedics announced ... Ponte Vedra, FL.  Since becoming the ... Champions Tour" over one year ago, the company has ... Tour combined, with its onsite activation the Stryker Mobility ... on the importance of joint health. Proving to be ...
Breaking Medicine Technology:Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 2Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 3Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 4Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 5Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 6Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 7Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 8Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 9Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 10Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 11Stryker Returns to TPC Sawgrass for THE PLAYERS Championship Alongside Former Tournament Winners Fred Funk and Hal Sutton 2Stryker Returns to TPC Sawgrass for THE PLAYERS Championship Alongside Former Tournament Winners Fred Funk and Hal Sutton 3
... Germany, September 1 Biosensors,International Group, Ltd ... a next-generation drug-eluting stent,developed by Biosensors, has ... Johnson & Johnson,s industry leading drug-eluting stent, ... angiographic,follow-up data. The results of the landmark ...
... against placebo, in reducing the ... stroke and hospitalization for congestive heart failure ... current standard of care, RIDGEFIELD, Conn., ... the,TRANSCEND(TM)* trial demonstrated that treatment with MICARDIS(R),(telmisartan) ...
Cached Medicine Technology:Biosensors DES Demonstrates Equivalent Safety and Efficacy to Industry Leading DES in First 'Real World, All Comers' Clinical Study 2Biosensors DES Demonstrates Equivalent Safety and Efficacy to Industry Leading DES in First 'Real World, All Comers' Clinical Study 3TRANSCEND(TM) Trial Results Presented at European Society of Cardiology Congress and Published in The Lancet 2TRANSCEND(TM) Trial Results Presented at European Society of Cardiology Congress and Published in The Lancet 3TRANSCEND(TM) Trial Results Presented at European Society of Cardiology Congress and Published in The Lancet 4TRANSCEND(TM) Trial Results Presented at European Society of Cardiology Congress and Published in The Lancet 5TRANSCEND(TM) Trial Results Presented at European Society of Cardiology Congress and Published in The Lancet 6TRANSCEND(TM) Trial Results Presented at European Society of Cardiology Congress and Published in The Lancet 7
Information on diagnosis and management of 500 common or important medical and surgical disorders....
The workhorse electric system....
... BD Safety Knife with BD Xstar Blade ... that protects the blade in prodedure and ... based on a grind-less process for manufacturing ... outstanding sharpness and consistency. The arch ...
Bio-Rad's Genetic Systems HIV-1/HIV-2 PLUS O EIA is a unique assay that detects the broadest range of HIV....
Medicine Products: