Navigation Links
A CNIO team creates a unique mouse model for the study of aplastic anaemia
Date:8/29/2012

Aplastic anaemia is characterised by a reduction in the number of the bone marrow cells that go on to form the different cell types present in blood (essentially red blood cells, white blood cells and platelets). In most cases, the causes of the disorder are hard to determine, but some patients have been found to have genetic alterations leading to a shortening of their telomeres (the end regions of chromosomes that protect and stabilise DNA).

A team at the Spanish National Cancer Research Centre (CNIO) led by Mara Blasco has successfully created a transgenic mouse model that simulates the disease in humans. And its study has allowed them to demonstrate the process linking telomere impairment with the condition. Their results are published today in the online edition of the journal Blood.

Telomeres and stem cells

Telomeres consist of a repetitive DNA sequence bound to a series of proteins, including Trf1, which guard them from degradation and/or damage. Using transgenic techniques, Blasco's team have managed to eliminate the Trf1 protein from mouse bone marrow, in order to explore its role in the tissue's function.

They found that when Trf1 is eliminated, the mice develop exactly the same symptoms as aplastic anaemia sufferers: bone marrow failure with the corresponding pancytopenia (a reduction in the number of red and white blood cells, as well as platelets). Also, the authors have shown for the first time that the absence of this protein causes a shortening of the telomeres of blood cell-producing stem cells which leads, in turn, to the progressive stress-induced death of the remaining stem cells in the tissue and, eventually, the death of the animal.

This discovery establishes the molecular bases of certain genetic variants of aplastic anaemia and opens a new line of attack via Trf1 to prevent the telomere shortening and cell death that trigger the disease. "We have generated an animal model for aplastic anaemia associated with short telomeres that may aid in the design and testing of new therapeutic strategies," confirms Blasco. These findings may also offer insights into other processes linked to telomere length, such as ageing and cancer.


'/>"/>

Contact: Juan J. Gmez
juanj.gomez@cnio.es
34-917-328-000
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Related medicine news :

1. NJIT designer creates an ergonomic chair for musicians
2. 'EMT Exam Ace' Creates Free EMT Resources Page
3. Mayo Clinic YES Board creates efficiencies in emergency rooms
4. Police officer stress creates significant health risks, study finds
5. Mayo Clinic creates tool to track real-time chemical changes in brain
6. Team creates new view of bodys infection response
7. Unique approach needed to accurately assess health of young adult cancer survivors
8. Unique physiology key to diagnosing and treating diabetes in Asian populations
9. FirstVitals Health and Wellness, Inc. awarded $4 Million CMS Innovation Grant for Unique Telehealth Diabetes Progam Focused on Glycemic Control and Prevention of Diabetic Foot Complications
10. Unique program bringing electronic medical record data to ambulances lauded
11. LA BioMed offers unique educational and research opportunity to local high school seniors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now ... of Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... Final Cut Pro X users can now reveal the media of their split ...
(Date:6/27/2016)... , ... June 27, 2016 ... ... the patient payment industry today announced its strategic partnership with Connance, a ... workflows. , The two companies’ proven, proprietary technology combine to provide health ...
(Date:6/27/2016)... Park, KS (PRWEB) , ... June 27, 2016 , ... ... in retailers of Eyeglasses . , Millions of individuals in the United States ... eyeglasses have become a way to both correct vision and make a fashion statement. ...
(Date:6/26/2016)... ... 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment ... Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This ... of the world’s leading providers of cereal and other breakfast foods. Its residents often ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... OAKLAND, N.J. , June 24, 2016 /PRNewswire/ ... in the design, development and manufacturing of collagen ... and regeneration announced today that Bill Messer ... Sales and Marketing to further leverage the growing ... surgery medical devices. Bill joins the ...
(Date:6/24/2016)... Va. , June 24, 2016 The ... set of recommendations that would allow biopharmaceutical ... (HCEI) with entities that make formulary and coverage decisions, ... the "value" of new medicines. The recommendations ... does not appear on the drug label, a prohibition ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ., ... developing innovative inhaled drugs, announced today that it was ... Investments reconstituted its comprehensive set of U.S. and ... "This is an important milestone for Pulmatrix," said Chief ... shareholder awareness of our progress in developing drugs for ...
Breaking Medicine Technology: