Navigation Links
A CNIO team creates a unique mouse model for the study of aplastic anaemia
Date:8/29/2012

Aplastic anaemia is characterised by a reduction in the number of the bone marrow cells that go on to form the different cell types present in blood (essentially red blood cells, white blood cells and platelets). In most cases, the causes of the disorder are hard to determine, but some patients have been found to have genetic alterations leading to a shortening of their telomeres (the end regions of chromosomes that protect and stabilise DNA).

A team at the Spanish National Cancer Research Centre (CNIO) led by Mara Blasco has successfully created a transgenic mouse model that simulates the disease in humans. And its study has allowed them to demonstrate the process linking telomere impairment with the condition. Their results are published today in the online edition of the journal Blood.

Telomeres and stem cells

Telomeres consist of a repetitive DNA sequence bound to a series of proteins, including Trf1, which guard them from degradation and/or damage. Using transgenic techniques, Blasco's team have managed to eliminate the Trf1 protein from mouse bone marrow, in order to explore its role in the tissue's function.

They found that when Trf1 is eliminated, the mice develop exactly the same symptoms as aplastic anaemia sufferers: bone marrow failure with the corresponding pancytopenia (a reduction in the number of red and white blood cells, as well as platelets). Also, the authors have shown for the first time that the absence of this protein causes a shortening of the telomeres of blood cell-producing stem cells which leads, in turn, to the progressive stress-induced death of the remaining stem cells in the tissue and, eventually, the death of the animal.

This discovery establishes the molecular bases of certain genetic variants of aplastic anaemia and opens a new line of attack via Trf1 to prevent the telomere shortening and cell death that trigger the disease. "We have generated an animal model for apl
'/>"/>

Contact: Juan J. Gmez
juanj.gomez@cnio.es
34-917-328-000
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NJIT designer creates an ergonomic chair for musicians
2. 'EMT Exam Ace' Creates Free EMT Resources Page
3. Mayo Clinic YES Board creates efficiencies in emergency rooms
4. Police officer stress creates significant health risks, study finds
5. Mayo Clinic creates tool to track real-time chemical changes in brain
6. Team creates new view of bodys infection response
7. Unique approach needed to accurately assess health of young adult cancer survivors
8. Unique physiology key to diagnosing and treating diabetes in Asian populations
9. FirstVitals Health and Wellness, Inc. awarded $4 Million CMS Innovation Grant for Unique Telehealth Diabetes Progam Focused on Glycemic Control and Prevention of Diabetic Foot Complications
10. Unique program bringing electronic medical record data to ambulances lauded
11. LA BioMed offers unique educational and research opportunity to local high school seniors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... over 20 years, Dr. David Cruz of Cruz Chiropractic Care ... just about every type of injury that can result from car ... twenty-plus years, the team at Doctors on Liens has ... doctor. With the combined breadth of experience between the ...
(Date:1/22/2015)... La Jolla, Calif. (PRWEB) January 22, 2015 ... and Assemblymembers Susan Bonilla (D-Concord) and Kristin Olsen ... (CHI) for their leadership in advancing biotechnology, biomedical ... Mitchell, Bonilla and Olsen each received the “2014 ...
(Date:1/22/2015)... Payday lending practices in four southern states ... distress to the states that permit them, according to ... on Race and Wealth. , While they generate hundreds ... at the same time substantially depress economic activity, according ...
(Date:1/22/2015)... 22, 2015 Compare-autoinsurance.org has released a new blog ... an auto insurance policy . , Some types of ... should check the newly released blog post to see if their ... dangerously damaged vehicles are some of the cars that cannot be ...
(Date:12/26/2014)... December 26, 2014 The US represents the ... report. In 2013, GlobalData’s forecast estimates that sales of branded ... market due to the high incidence of the disease, high ... 5EU, Japan, and China. Increased sales of CRC therapies over ...
Breaking Medicine News(10 mins):Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 3Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 4
... shorter life for men, study finds , , FRIDAY, March 14 ... live longer, but may harm older men, U.S. research ... Case Western Reserve University followed 1,000 seniors in three Florida ... that women with higher levels of anxiety at the start ...
... with Elected Officials, WASHINGTON, March 14 Nyle ... April 1 to meet with,congressional leaders and gain their ... for epilepsy public health,programs and more research toward a ... young people with epilepsy participating in Kids,Speak Up!, a ...
... Visit Washington, D.C., and Meet With Elected Officials, ... travel to Washington, D.C., this April 1 to meet ... the,Americans with Disabilities Act, support for epilepsy public health,programs ... Soeby, 10, is one of 50 young people with ...
... to Visit Washington, D.C., and,Meet with Elected Officials, ... and Nicklaus Schliesmann of Holmen will travel to ... leaders and gain their,support for restoration of the ... programs and more research toward a cure for,epilepsy., ...
... Visit Washington, D.C., and Meet with,Elected Officials, WASHINGTON, ... of San Antonio will travel to Washington, D.C.,this April ... support for,restoration of the Americans with Disabilities Act, support ... cure for epilepsy., Eubank and Fitzhugh, both 14, ...
... Inc. (Nasdaq: BDMS ), operators of PERFECT ... Company,s board of directors,has declared a quarterly cash ... The dividend is payable April 11, 2008, to ... Management Services, Inc. acquires, develops, and manages,geographically dense ...
Cached Medicine News:Health News:Anxiety Helps Elderly Women Live Longer 2Health News:Florida Youth Named National Epilepsy Spokesperson 2Health News:Arizona Youth Named National Epilepsy Spokesperson 2Health News:Wisconsin Youths Named National Epilepsy Spokespersons 2Health News:Texas Youths Named National Epilepsy Spokespersons 2
(Date:1/23/2015)... 23, 2015  Northwest Biotherapeutics, Inc. (NASDAQ: NWBO )("NW ... for operable and inoperable solid tumor cancers, announced today that ... th Annual Phacilitate Immunotherapy Forum in Washington ... will take place on January 26 at 10:30 a.m. EST ...
(Date:1/23/2015)... a third of reproductive-aged women enrolled in Medicaid, and more ... prescription for an opioid pain medication each year during 2008-2012, ... Weekly Report (MMWR). Opioids are typically prescribed ... They are also found in some prescription cough medications. The ...
(Date:1/23/2015)... Feffer LLP ( www.hfesq.com ) is investigating potential claims ... or the "Company") (NASDAQ: ADXS ), concerning ... shareholders. On January 21, 2015, an article ... had misrepresented the clinical data for its ADXS-HPV drug ...
Breaking Medicine Technology:NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2
... announces that a new market research report is available ... http://www.reportlinker.com/p0357031/Regenerative-Medicine-Markets.html Regenerative ... human tissue by using laboratory-grown or therapeutically-induced human tissue ... the ability to repair or replace damaged human tissue ...
... YORK, Dec. 29, 2010 Reportlinker.com announces that ... its catalogue: 2010-2015 In-depth Research ... http://www.reportlinker.com/p0356862/2010-2015-In-depth-Research-Report-on-China-Sodium-Fluoride-Industry.html Report ... State Statistical Bureau, General Administration of Custom, Ministry ...
Cached Medicine Technology:Reportlinker Adds Regenerative Medicine Markets 2Reportlinker Adds 2010-2015 In-depth Research Report on China Sodium Fluoride Industry 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: