Navigation Links
A CNIO team creates a unique mouse model for the study of aplastic anaemia
Date:8/29/2012

Aplastic anaemia is characterised by a reduction in the number of the bone marrow cells that go on to form the different cell types present in blood (essentially red blood cells, white blood cells and platelets). In most cases, the causes of the disorder are hard to determine, but some patients have been found to have genetic alterations leading to a shortening of their telomeres (the end regions of chromosomes that protect and stabilise DNA).

A team at the Spanish National Cancer Research Centre (CNIO) led by Mara Blasco has successfully created a transgenic mouse model that simulates the disease in humans. And its study has allowed them to demonstrate the process linking telomere impairment with the condition. Their results are published today in the online edition of the journal Blood.

Telomeres and stem cells

Telomeres consist of a repetitive DNA sequence bound to a series of proteins, including Trf1, which guard them from degradation and/or damage. Using transgenic techniques, Blasco's team have managed to eliminate the Trf1 protein from mouse bone marrow, in order to explore its role in the tissue's function.

They found that when Trf1 is eliminated, the mice develop exactly the same symptoms as aplastic anaemia sufferers: bone marrow failure with the corresponding pancytopenia (a reduction in the number of red and white blood cells, as well as platelets). Also, the authors have shown for the first time that the absence of this protein causes a shortening of the telomeres of blood cell-producing stem cells which leads, in turn, to the progressive stress-induced death of the remaining stem cells in the tissue and, eventually, the death of the animal.

This discovery establishes the molecular bases of certain genetic variants of aplastic anaemia and opens a new line of attack via Trf1 to prevent the telomere shortening and cell death that trigger the disease. "We have generated an animal model for aplastic anaemia associated with short telomeres that may aid in the design and testing of new therapeutic strategies," confirms Blasco. These findings may also offer insights into other processes linked to telomere length, such as ageing and cancer.


'/>"/>

Contact: Juan J. Gmez
juanj.gomez@cnio.es
34-917-328-000
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Related medicine news :

1. NJIT designer creates an ergonomic chair for musicians
2. 'EMT Exam Ace' Creates Free EMT Resources Page
3. Mayo Clinic YES Board creates efficiencies in emergency rooms
4. Police officer stress creates significant health risks, study finds
5. Mayo Clinic creates tool to track real-time chemical changes in brain
6. Team creates new view of bodys infection response
7. Unique approach needed to accurately assess health of young adult cancer survivors
8. Unique physiology key to diagnosing and treating diabetes in Asian populations
9. FirstVitals Health and Wellness, Inc. awarded $4 Million CMS Innovation Grant for Unique Telehealth Diabetes Progam Focused on Glycemic Control and Prevention of Diabetic Foot Complications
10. Unique program bringing electronic medical record data to ambulances lauded
11. LA BioMed offers unique educational and research opportunity to local high school seniors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... Boyd Industries, a leading supplier of dental ... new product for pediatric dentistry , at AAPD 2016, the annual conference and ... 26-29. The Concealed Delivery Unit keeps dental hand pieces and other anxiety-provoking pieces of ...
(Date:5/24/2016)... ... 24, 2016 , ... Eggsurance, the first independent, non-clinic related ... community and education hub for women considering fertility preservation, as well as those ... and welcoming place for women to find cycle buddies, get clinic recommendations and ...
(Date:5/24/2016)... ... May 24, 2016 , ... American ... (Jon) Otterstatter to its board of directors. Otterstatter is co-founder, president and ... development of technological innovations that lead to broad-based healthcare solutions. , “Jon knows ...
(Date:5/24/2016)... ... May 24, 2016 , ... Bio-Logic Aqua® Research ... forty years and a trainer for Ageless Grace ( http://www.agelessgrace.com ) to discuss ... on May 16, 2016. , Formerly a Northwestern University Literature Professor, Kinst gravitated ...
(Date:5/24/2016)... ... 2016 , ... Controlling and maintaining the home’s water heater just got infinitely ... Water Heater Controller , a first-of-its-kind system that enables remote and convenient control of ... thermostat does for HVAC systems, Aquanta gives users a much more efficient, versatile way ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... , May 24, 2016 ... ™ , la première endoprothèse à ... destinés à l,intervention portant sur les membres ... OrbusNeich, entreprise mondiale spécialisée dans ... changer la vie, a élargi son portefeuille ...
(Date:5/24/2016)... Een app die artsen over ... patiënten kunnen behandelen, hun kennis kunnen delen en van ... nieuwe en revolutionaire MDLinking App, ontwikkeld door een internationale ... Hans Flu en oncologisch chirurg dr. Gijs van ... wordt op dinsdag 24 mei officieel gepresenteerd op het ...
(Date:5/23/2016)... Diplomat Pharmacy, Inc. (NYSE: DPLO) announced today the ... The hands-on learning experience is a 12-week summer program, ... Fellowship and Internship programs bring participants ... interns are provided optional housing free of charge through ... the Riverfront Residence Hall to foster communication and collaboration ...
Breaking Medicine Technology: