Navigation Links
A Blood Marker Could Spot Diabetes Risk
Date:7/8/2008

Higher levels of fetuin-A were linked to later disease development, study found,,,,

TUESDAY, July 8 (HealthDay News) -- Rising levels of a blood protein called fetuin-A may indicate an elevated risk of developing type 2 diabetes, new research suggests.

Reporting in the current issue of the Journal of the American Medical Association, researchers from the University of California, San Diego, found that older people with the highest levels of fetuin-A were more likely to develop diabetes than those with lower levels.

"If fetuin-A can really differentiate diabetes risk, it gives us an opportunity for public health interventions," said the study's lead author, Dr. Joachim Ix, an assistant professor of medicine at the University of California, San Diego, and the San Diego Veterans Affairs Healthcare System.

Ix said that interventions to fight diabetes, such as healthy diet and exercise, can be difficult to accomplish on a wide scale. However, efforts could be made easier "if we could use something like fetuin to identify people with the highest risk," he said.

According to the American Diabetes Association (ADA), almost 21 million Americans now have diabetes. Most of them have the type 2 form of the disease, which is often linked to obesity. People with type 2 diabetes either don't produce enough insulin, or their bodies become desensitized to insulin and can't effectively use it. Untreated, diabetes can lead to a number of complications, including heart disease, stroke, kidney failure, blindness and more, according to the ADA.

The exact cause of type 2 diabetes still remains elusive. For example, being overweight is a significant risk factor for developing the disease, but not everyone who's overweight or obese will become diabetic. Fetuin-A is a protein secreted by liver cells that may play a role in insulin resistance -- the precursor to type 2 diabetes.

The current study included 406 people between 70 and 79 years old, all of who had their fetuin-A levels measured at the beginning of the study. At the time, none of them had diabetes.

Six years later, 135 of the study participants had developed diabetes.

Those with the highest fetuin-A levels had twice the risk of diabetes than those with the lowest levels -- 13.3 per 1,000 person-years compared to 6.5 cases per 1,000 person-years, the researchers found.

The team adjusted the data to account for other known diabetes risk factors, such as age, physical activity levels, body mass, and more. The association between diabetes and fetuin-A remained, except for when the researchers controlled for abdominal fat.

"When we adjusted for visceral fat, the link between fetuin and diabetes was still there, but was weaker," said Ix.

One expert said the findings are likely only a beginning.

"This is a very preliminary result which suggests that there might be a relationship between fetuin-A and diabetes, and this study suggests a potential target for drug development, but it's something that will take years to tease out," said Dr. John Buse, president of medicine and science at the American Diabetes Association, and director of the diabetes care center at the University of North Carolina School of Medicine, Chapel Hill.

Ix agreed that the findings need to be confirmed by other researchers. But he also believes that this work is a jumping off point for other research.

"This study suggests that there are factors coming from the liver that might control glucose, and there's a chance that this might ultimately lead to new treatments and screening strategies," said Ix.

More information

To learn more about preventing type 2 diabetes, visit the American Diabetes Association.



SOURCES: Joachim Ix, M.D., assistant professor, medicine, division of nephrology, department of family and preventive medicine, University of California, San Diego, and assistant professor, medicine, nephrology section, San Diego Veterans Affairs Healthcare System; John Buse, M.D., president, medicine and science, American Diabetes Association, and director, diabetes care center, University of North Carolina School of Medicine, Chapel Hill; July 9, 2008, Journal of the American Medical Association


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Ankle-Arm Blood Pressure Test Predicts Heart Disease Risk
2. Fish oil and red yeast rice studied for lowering blood cholesterol
3. The Foundation for Accelerated Vascular Research Grants $150,000 Wylie Scholar Award for Blood Vessel Research
4. Unilever Unveils Promise(R) SuperShots(R) for Blood Pressure, the First Functional Shot to Increase Daily Potassium Intake to Help Reduce the Risk of High Blood Pressure
5. Taking Control: Future Therapies for a Host of Serious Diseases May Be Found in Womens Menstrual Blood
6. FDA Grants AMDL Clearance to Market the AMDL-ELISA DR-70(R) (FDP) Blood Test for Monitoring Colorectal Cancer
7. Working Hard When Tired Raises Blood Pressure
8. Blood vessel inhibitor shows promise against metastatic thyroid cancer
9. Hibernation-on-demand drug significantly improves survival after extreme blood loss
10. Release of Kowalski Book on Attaining Healthy Blood Pressure Coincides with Website Launch, New Endurance Products SR L-Arginine and Grape Seed Extract
11. Scientists find how neural activity spurs blood flow in the brain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A Blood Marker Could Spot Diabetes Risk
(Date:5/31/2016)... , ... May 31, 2016 , ... According to recent ... States, and more than 100,000 physical therapy clinics. Each physical therapy professional and ... of clients. At the same time, staying afloat in a competitive industry is also ...
(Date:5/31/2016)... ... , ... Throughout the day, adults often find themselves reaching for a cup of coffee, an ... be reaching for instead is a cup of Matcha green tea. Matcha is a premium ... tea is harvested from early June to mid-July, when the leaves are the most tender. ...
(Date:5/31/2016)... ... , ... Twenty years ago it was revolutionary: enabling the people who hear ... they hear. But this approach has proven transformative, both for people who hear voices ... and now is used around the world, but it still lags in the United ...
(Date:5/31/2016)... ... May 31, 2016 , ... ... device that enables unprecedented portability and convenience. , The Cube is exceptionally small—it ... in size, the Cube fits easily into any space, whether in a hospital, ...
(Date:5/31/2016)... ... May 31, 2016 , ... WaterField Designs, an innovative ... announces the waxed-canvas and leather Duo Dopp Kit , the ideal gift upgrade ... ballistic nylon, the Duo is smartly designed for Dad’s grooming routine. Two ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... 2016 PaperHive Will Enable ... Elsevier,s ScienceDirect Database Elsevier , ... information products and services, today announced it will ... collaboration platform PaperHive to enable researchers to easily discover, ... on ScienceDirect , the world,s largest database ...
(Date:5/31/2016)... PUNE, India , May 31, 2016 ... 2016" market research report with comparative analysis of Asthma ... mechanism of action (MoA), route of administration (RoA) and ... and press releases. It also reviews key players involved ... on late-stage and discontinued projects. Complete report ...
(Date:5/30/2016)... , May 30, 2016 On ... eliminate viral hepatitis by 2030. At the 69 th ... ever Global Viral Hepatitis Strategy, signalling the greatest global commitment ... a goal of eliminating hepatitis B and C by 2030 ... if reached, will reduce annual deaths by 65% and increase ...
Breaking Medicine Technology: