Navigation Links
70 percent of prostate cancer patients on ADT gain significant weight in first year
Date:3/11/2011

Seventy per cent of men who received androgen-deprivation therapy (ADT) after surgery to remove their prostate gland gained significant weight in the first year, putting on an average of 4.2kg, according to a paper in the March issue of the urology journal BJUI.

Researchers studied the recorded weights of 132 men who underwent radical prostatectomy between 1988 and 2009 at four US Veterans Affairs Medical Centers in California, Georgia and North Carolina, before and after they received ADT.

This showed that the majority of the men gained significant weight during the first year of therapy, but did not put on any more weight after that.

"ADT is a hormone therapy that deprives the patient's body of androgens, such as testosterone, which have been shown to stimulate the growth of prostate cancer cells" explains Dr Stephen J Freedland, from the Duke Prostate Center at Duke University School of Medicine and the Veteran Affairs Medical Center, Durham, North Carolina.

"Having been established as the mainstay treatment for recurrent or secondary prostate cancer, ADT is now being increasingly used to treat localised disease.

"This rising use of ADT makes it even more important that we pay close attention to the side-effects of the therapy, including weight gain, as obesity is linked with a number of chronic and potentially life-threatening health problems."

Dr Freedland teamed up with colleagues from four other US states to carry out the study, using data from the Shared Equal Access Regional Cancer Hospital database. Patients were included if there was sufficient information to track their weight before and after the use of ADT.

The average age of the men included in the study was 66 years, 50 per cent were white, 42 per cent were black and eight per cent were from other races. Their average Body Mass Index before starting ADT was 29. The men's weight was measured a median of 33 days before and 363 days after the start of their ADT therapy.

Key findings of the study included:

  • 70 per cent of the men gained weight, 26 per cent lost weight and four per cent stayed the same. The men who put on weight gained an average of 4.2kg, while the men who lost weight lost an average of 2.4kg. The total weight gain averaged across all of the 132 men in the study was 2.2kg or 2.4 per cent of their body weight.

  • Data covering the year before ADT and the second year after ADT was available for 64 per cent of the men. This showed that most of the significant weight gain took place in the first year after ADT therapy started. Their overall weight gain averaged 2.1kg in the first year, with no change in the second year.

  • Weight gainers and losers did not differ in any demographic, clinical or pathological respects.

"Despite its clinical efficacy in advanced prostate cancer, ADT is associated with an array of adverse side-effects such as insulin resistance and increased risk of cardiovascular disease" says Howard Kim, a medical student at Duke University School of Medicine and first author of the study.

"A growing number of studies show that men receiving ADT undergo a shift in body mass composition, gaining weight by increasing body fat and losing bone density and lean muscle mass.

"The most notable finding of our study is that any significant weight gain tends to occur in the year after ADT therapy begins and then stabilises after that. Previous studies have tended to concentrate on the short timeframe immediately after ADT is initialised, whereas much of our data covers a three-year time-span. This has enabled us to provide a clearer picture, not only of how much weight patients can gain on ADT, but when any significant weight gain occurs."


'/>"/>

Contact: Annette Whibley
annette.wizard@gmail.com
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Experts call for greater pain assessment in hospitals as 65 percent of patients report problems
2. Hearing loss rate in older adults climbs to more than 60 percent in national survey
3. Chronically ill children are 88 percent more likely to suffer physical abuse
4. Study finds women used 30 percent less analgesia during labor when self-administered
5. New national study finds mountain bike-related injuries down 56 percent
6. Safety checklist use yields 10 percent drop in hospital deaths
7. New national study finds 34 percent increase in running-related injuries among children
8. Yearly mammograms from age 40 save 71 percent more lives, study shows
9. Metabolic syndrome found in 52 percent of patients after liver transplantation
10. Low-dose aspirin reduces death rates from range of cancers by between 20 and 30 percent
11. New report: Employer health insurance premiums increased 41 percent from 2003 to 2009
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are confused ... endometriosis. These women need a treatment plan to not only alleviate symptoms and ... help for preservation of fertility and ultimately achieving a pregnancy. The specialists at ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... ... , ... June 19, 2016 is World Sickle Cell Observance Day. In an ... of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a ... Cell Disease (SCD) is a disorder of the red blood cells, which can cause ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... ... is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Guerbet announced today that it has been named a ... One of 12 suppliers to receive the ... of Premier members through exceptional local customer service and ... lower costs. "We ... customer service from Premier," says Massimo Carrara , ...
(Date:6/23/2016)... June 23, 2016 Research and ... Procedure Volumes: Global Analysis (United States, China, Japan, Brazil, ... report to their offering. ... for healthcare business planners, provides surgical procedure volume data ... trends with an in-depth analysis of growth drivers and ...
(Date:6/23/2016)... The Biotechnology industry might still ... great opportunities to investors. Stock-Callers.com assesses the recent performances ... XON ), Vertex Pharmaceuticals Inc. (NASDAQ: ... ARNA ), and Regeneron Pharmaceuticals Inc. (NASDAQ: ... your complimentary trade alerts at: http://stock-callers.com/registration ...
Breaking Medicine Technology: