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7 in 1 blow: Scientists discover DNA regions influencing prostate cancer risk
Date:7/12/2011

elevated prostate cancer risk. Together with the results of prior association studies, about 30 risk genes for prostate cancer were known then. In the third and last round the research consortium searched in 4,574 cancer patients and 4,164 controls for another 1,536 SNPs. The emerging associations with cancer risk were then verified once more using 51,311 DNA samples of cancer patients and healthy men.

Alongside a number of already identified variants, the investigators found seven SNPs that emerged for the first time in association with an elevation in prostate cancer risk. The variants are all located in DNA regions that also contain genes for which the scientists consider it plausible that they play a role in carcinogenesis. However, an association with the malignancy of cancer could not be established for any of these variants. With the seven newly discovered DNA regions, scientists are now able to explain about 25 percent of familial cancer risk.


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Contact: Dr. Sibylle Kohlstdt
s.kohlsaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

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