Navigation Links
7 in 1 blow: Scientists discover DNA regions influencing prostate cancer risk
Date:7/12/2011

Doctors have known for a long time that prostate cancer "runs in the family". Men with relatives who have been diagnosed with prostate cancer have an elevated risk of also developing this type of cancer. It was only last year that DKFZ scientists calculated that this risk rises with the number of affected direct family members and also depends on the relatives' age at outbreak of the disease (DKFZ Press Release 18/2010).

The exact DNA variants that contribute to prostate cancer risk have now been published by an international research consortium with participation of scientists from the German Cancer Research Center. In a multi-stage study, the collaborators systematically searched the whole genome of cancer patients and healthy controls for specific gene variants. Then they calculated whether specific variants are found more often in patients than in healthy people.

Professor Dr. Hermann Brenner, one of the DKFZ researchers participating in the consortium, explains: "Each of these gene variants taken on its own is associated with only a slight increase in prostate cancer risk by a few percent. However, by taking account of the different variants at the same time it becomes possible to identify groups of persons who have a significantly elevated risk. Examining the genetic material for such risk variants might therefore improve medical consultation on the prevention and early detection of prostate cancer in the future."

Such DNA variants are scientifically called single nucleotide polymorphisms (SNPs). They are defined as a single variation of a nucleotide which occurs with varying frequency in the whole population. If a relationship in numbers is found between a particular SNP and cancer incidence, researchers conclude that a gene within the affected DNA region plays a role in cancer.

The first two study stages conducted by the consortium had already identified 16 SNPs in 16 different DNA regions to be associated with an
'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlsaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Gold nanoparticles bring scientists closer to a treatment for cancer
2. Scientists identify order of mutations that lead to cancer
3. Scientists discover new molecular pathway involved in wound-healing and temperature sensation
4. Neuroscientists find famous optical illusion surprisingly potent
5. Scientists sequence endangered Tasmanian devils genome
6. Scientists identify a novel mechanism for evolution of highly aggressive cancers
7. Singapore scientists discover how to control fate of stem cells
8. Scientists Zero In on Key Melanoma Links
9. Scientists develop first ever drug to treat Celtic gene in cystic fibrosis sufferers
10. Scientists Turn Memory On, Off in Rats With Flip of Switch
11. Scientists Pinpoint Parts of Brain That Help People Recognize Themselves
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... (PRWEB) September 21, 2014 High in ... teams of disabled and able-bodied athletes rafted the Colorado ... a ropes course in pursuit of outdoor adventure. At ... national non-profit World T.E.A.M. Sports, disabilities proved to be ... successfully completed the three stage event. , Each participating ...
(Date:9/21/2014)... experienced review website in the global market, Top10BestSEOHosting.com, has ... that FatCow ( http://www.top10bestseohosting.com/go/FatCow.com/ ), GoDaddy and Bluehost are ... been a boom in websites in recent years, and ... the number of web hosting companies that offer a ... (Virtual Private Server) is the method of partitioning a ...
(Date:9/21/2014)... BambooIndustry.com, an experienced producer of natural bamboo items, has ... http://www.bambooindustry.com/products/bamboo-panel/ ). The company’s excellent panels are very popular ... discounted prices now, from 10 to 30 percent off. ... are available in many specifications; they are promised to ... finely manufactured by qualified workers. They are specially offered ...
(Date:9/21/2014)... Faculty and staff at Garrison Forest School ... Owings Mills, Md., kicked off the academic year by taking ... is the first independent school to receive the bands— which ... sleep patterns— as part of a pilot program with ... specialty chain. The Vivofit bands are just one tool in ...
(Date:9/21/2014)... According to latest National Vital Statistics Reports ... (10.5 births per 1,000 women in 2013). Since 2000, the ... by 2 percent per year. The birth rate for women ... over) also rose, the first such increase since 2008. Ultimately ... as many first births to women aged 35 and older ...
Breaking Medicine News(10 mins):Health News:Disabled Athletes Excel at World T.E.A.M. Sports’ Adventure Team Challenge 2Health News:Disabled Athletes Excel at World T.E.A.M. Sports’ Adventure Team Challenge 3Health News:Top10BestSEOHosting.com: FatCow, GoDaddy And Bluehost Are The Best VPS Hosting Suppliers 2Health News:Discounted Bamboo Panels For Sale At BambooIndustry.com 2Health News:Garrison Forest School Leader in Independent School Wellness Programs 2Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 2Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 3Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 4
... Md., Dec. 7, 2011 A research team led by scientists ... this week showing how a bacterium, Helicobacter pylori , that ... been implicated in stomach cancer has managed for eons to turn ... it can thrive. Writing in a Journal of Biological ...
... recognize the following scenario: Their favorite player scores a three-point ... ball. But does the fact that he scored the last ... it change the probability that he will score again? ... Neiman at the Hebrew University in Jerusalem shatters the myth ...
... TUESDAY, Dec. 6 (HealthDay News) -- A woman,s risk of ... or is obese after age 60, a new study indicates. ... risk, but "the diabetes link had not been clearly shown," ... Lund University in Lund, Sweden. He is scheduled to ...
... symptoms following birth also reported intimate partner violence finds a ... International Journal of Obstetrics and Gynaecology . The study ... symptoms first reported this at six months after birth or ... abuse) in the perinatal period is associated with a range ...
... - Accelerated partial breast irradiation (APBI) brachytherapy, the ... as a treatment choice for women with early-stage ... later mastectomy, increased radiation-related toxicities and post-operative complications, ... to researchers from The University of Texas MD ...
... Supercomputer simulations at the Department of Energy,s Oak Ridge ... key class of proteins involved in drug detoxification. ... affiliated with ORNL and the University of Tennessee, have ... in a class of enzymes called P450s. Certain types ...
Cached Medicine News:Health News:Closing in on an ulcer- and cancer-causing bacterium 2Health News:Closing in on an ulcer- and cancer-causing bacterium 3Health News:Heads up Kobe Bryant! Research shows that trying for another 3-pointer is a mistake 2Health News:Diabetes, Obesity After 60 May Drive Up Breast Cancer Risk 2Health News:Depressive symptoms and intimate partner violence in the 12 months after childbirth 2Health News:Study finds side effects, complications, mastectomy more likely after partial breast irradiation 2Health News:Study finds side effects, complications, mastectomy more likely after partial breast irradiation 3Health News:Supercomputer reveals new details behind drug-processing protein model 2
(Date:9/19/2014)... 2014 The Parenteral Drug Association (PDA) is ... changes protocols. The new initiative stems ... by industry participants and regulatory authority representatives at the ... Washington, DC . Representatives of both ... the workshop. Attendees indicated openness to engaging regulators and ...
(Date:9/19/2014)... , Sept. 19, 2014 /PRNewswire-iReach/ ... Outlook to 2020″, provides key market ... Surgery devices market. The report provides ... and volume (in units) within market ... Colonoscopes, Sigmoidoscopes, Esophagoscopes & Gastroscopes, Duodenoscopes, ...
(Date:9/19/2014)... 19, 2014  The board of directors of AbbVie ... cash dividend of $0.42 per share.  ... stockholders of record at the close of business on ... a global, research-based biopharmaceutical company formed in 2013 following ... its expertise, dedicated people and unique approach to innovation ...
Breaking Medicine Technology:PDA Launches Effort to Harmonize Global Post-Approval Changes Protocols 2United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 2United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 3United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 4United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 5
... David B. Snow Jr. , chairman and chief executive officer, Medco Health Solutions, ... Health Care Conference in New York on Wednesday, May 26, 2010 . , ... The presentation at the Hilton, New York , will begin at ... to attend. , , , ...
... 20 As the medical device industry gathers at Sales ... Management software, offers medical device companies a solution to promote and sell ... , , ... will lead the workshop "Sales-Friendly Compliant Content Communication: How to Score Wins ...
Cached Medicine Technology:Medco to Present at the 2010 Citi Investment Research Global Health Care Conference 2Prolifiq Offers Best Practices Solution for Selling Medical Devices in Tough Regulatory Environment 2Prolifiq Offers Best Practices Solution for Selling Medical Devices in Tough Regulatory Environment 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: