Navigation Links
7 in 1 blow: Scientists discover DNA regions influencing prostate cancer risk
Date:7/12/2011

Doctors have known for a long time that prostate cancer "runs in the family". Men with relatives who have been diagnosed with prostate cancer have an elevated risk of also developing this type of cancer. It was only last year that DKFZ scientists calculated that this risk rises with the number of affected direct family members and also depends on the relatives' age at outbreak of the disease (DKFZ Press Release 18/2010).

The exact DNA variants that contribute to prostate cancer risk have now been published by an international research consortium with participation of scientists from the German Cancer Research Center. In a multi-stage study, the collaborators systematically searched the whole genome of cancer patients and healthy controls for specific gene variants. Then they calculated whether specific variants are found more often in patients than in healthy people.

Professor Dr. Hermann Brenner, one of the DKFZ researchers participating in the consortium, explains: "Each of these gene variants taken on its own is associated with only a slight increase in prostate cancer risk by a few percent. However, by taking account of the different variants at the same time it becomes possible to identify groups of persons who have a significantly elevated risk. Examining the genetic material for such risk variants might therefore improve medical consultation on the prevention and early detection of prostate cancer in the future."

Such DNA variants are scientifically called single nucleotide polymorphisms (SNPs). They are defined as a single variation of a nucleotide which occurs with varying frequency in the whole population. If a relationship in numbers is found between a particular SNP and cancer incidence, researchers conclude that a gene within the affected DNA region plays a role in cancer.

The first two study stages conducted by the consortium had already identified 16 SNPs in 16 different DNA regions to be associated with an elevated prostate cancer risk. Together with the results of prior association studies, about 30 risk genes for prostate cancer were known then. In the third and last round the research consortium searched in 4,574 cancer patients and 4,164 controls for another 1,536 SNPs. The emerging associations with cancer risk were then verified once more using 51,311 DNA samples of cancer patients and healthy men.

Alongside a number of already identified variants, the investigators found seven SNPs that emerged for the first time in association with an elevation in prostate cancer risk. The variants are all located in DNA regions that also contain genes for which the scientists consider it plausible that they play a role in carcinogenesis. However, an association with the malignancy of cancer could not be established for any of these variants. With the seven newly discovered DNA regions, scientists are now able to explain about 25 percent of familial cancer risk.


'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlsaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Related medicine news :

1. Gold nanoparticles bring scientists closer to a treatment for cancer
2. Scientists identify order of mutations that lead to cancer
3. Scientists discover new molecular pathway involved in wound-healing and temperature sensation
4. Neuroscientists find famous optical illusion surprisingly potent
5. Scientists sequence endangered Tasmanian devils genome
6. Scientists identify a novel mechanism for evolution of highly aggressive cancers
7. Singapore scientists discover how to control fate of stem cells
8. Scientists Zero In on Key Melanoma Links
9. Scientists develop first ever drug to treat Celtic gene in cystic fibrosis sufferers
10. Scientists Turn Memory On, Off in Rats With Flip of Switch
11. Scientists Pinpoint Parts of Brain That Help People Recognize Themselves
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network ... advocate for action towards gender equality at their inaugural Summit in New York City ... and reached a social audience of over 3 million. To watch the Mobilize Women ...
(Date:10/13/2017)... ... 2017 , ... “The Journey: From the Mountains to the Mission Field”: the ... in the Philippines. “The Journey: From the Mountains to the Mission Field” is the ... She has taught all ages and currently teaches a class of ladies at her ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed ... consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has ... highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, the Los ... article to the newly revamped Cosmetic Town journal section, featuring articles ... procedure known as Follicular Unit Extraction (FUE). , Dr. Mohebi says ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... first interactive health literacy software tool, and the Cancer Patient Education Network (CPEN), ... patient education, today announce a new strategic alliance. , As CPEN’s strategic ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... SAN DIEGO , Oct. 12, 2017 ... has recognized the company with their  2017 New Product Innovation ... is based on extensive primary and secondary medical device market ... AVACEN Medical, through its first-to-market OTC, drug-free pain relief product, ... a unique approach to treating fibromyalgia widespread pain. ...
(Date:10/11/2017)... 11, 2017  True Health, a leader in ... effort during National Breast Cancer Awareness month to ... Research recently ... that more than 10 million American women are ... BRCA1 or BRCA2 and have not had testing. These ...
(Date:10/5/2017)... 2017  In response to the nationwide opioid ... Surgeons (AAOMS) released prescribing recommendations that urge ibuprofen ... as a first-line therapy to manage a patient,s ... Recognizing the value and importance of ... Prescribing: Acute and Postoperative Pain Management" stresses that ...
Breaking Medicine Technology: