Navigation Links
60 Million Worldwide Carry Heart Disease Mutation
Date:1/23/2009

Muscle protein variant, most common in India, leaves carriers with little warning of dangers

FRIDAY, Jan. 23 (HealthDay News) -- About 60 million people worldwide carry a gene mutation that almost always causes heart disease, but the mutation is most common among people in India, according to a study by 25 researchers from four countries.

Heart disease is the leading cause of death in the world. By 2010, India will account for about 60 percent of the world's heart disease, said the researchers, who analyzed the DNA of about 800 patients at cardiac centers in India. The study was published in the Jan. 18 issue of Nature Genetics.

The mutation, a deletion of 25 letters of genetic code from the heart protein gene MYBPC3, was discovered five years ago in two Indian families with a history of cardiomyopathy, an enlargement or abnormal thickening of the heart muscle that weakens the heart and reduces its ability to pump blood.

The genetic risk of heart disease is expressed as an odds ratio. A small effect would be 1:2 and a large effect would be 2:0. The researchers said the odds ratio for people with the MYBPC3 mutation is almost off the scale, 7:0. People with the mutation usually have few symptoms until middle age. But after that, most develop symptoms and are at risk for sudden cardiac death.

"The mutation leads to the formation of an abnormal protein. Young people can degrade the abnormal protein and remain healthy, but as they get older, it builds up and eventually results in the symptoms we see," study leader Kumarasamy Thangaraj, Center for Cellular and Molecular Biology in Hyderabad, India, said in a news release issued by the Wellcome Trust Sanger Institute.

The researchers believe the mutation arose about 30,000 years ago in India, and spread because its effects usually develop only after people with the mutation have had children.

"The bad news is that many of these mutation carriers have no warning that they are in danger, but the good news is, that we now know the impact of this mutation," Perundurai S. Dhandapany, of Madurai Kamaraj University in Madurai, India, said in the news release.

Genetic screening can identify carriers of the mutation at a young age. It may be possible to develop drugs to combat the abnormal protein caused by the mutation and postpone the onset of symptoms.

More information

The U.S. Centers for Disease Control and Prevention has more about heart disease.



-- Robert Preidt



SOURCE: Wellcome Trust Sanger Institute, news release, Jan. 18, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. HHS Announces $75 Million in Supplemental Funding to States for Pandemic Flu Preparedness
2. AUDIO from Medialink and Pfizer: Number of Uninsured Americans Grows to 47 Million
3. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
4. 1.5 million children could be saved
5. The Philadelphia Walk Now for Autism Expected to Draw 10,000 Walkers and Raise $1 Million to Help Find Answers About the Nations Fastest-Growing Developmental Disorder
6. UVa researcher awarded $3.6 million grant to fight drug-resistant bacteria
7. EaglePicher Corporation Completes Transaction to Sell EaglePicher Boron, LLC to Ceradyne, Inc. for $69 Million
8. R. P. Simmons Family Foundation Pledges $2 Million for New Childrens Hospital of Pittsburgh of UPMC Campus
9. £5 million investment in personalized medicines to cut patient deaths
10. Keane Wins $1 Million Electronic Medical Record (EMR) Implementation at New Jersey-Based Acute Care Facility
11. PainCare Receives $14.4 Million in Cash From Completed Sale of South Florida Ambulatory Surgery Centers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
60 Million Worldwide Carry Heart Disease Mutation
(Date:5/3/2016)... ... 03, 2016 , ... The new web-based solution HIPAA ... practices, to better grasp and implement HIPAA’s privacy, security, and data breach requirements. ... well-defined, expert-created path to compliance. HIPAA Institute has positioned itself to be an ...
(Date:5/2/2016)... ... May 03, 2016 , ... RNK ... sSOIP telemedicine stethoscope software that enables the stethoscope stream to go over the ... works with RNK’s flagship PCP-USB stethoscope. , Remote auscultation involves two software elements ...
(Date:5/2/2016)... ... May 02, 2016 , ... The Beryl Institute announces ... (PXJ), an international, open access, peer-reviewed journal focused on research and proven practices ... (non-US) based authors, the third volume of PXJ continues to expand PXJ's reach ...
(Date:5/2/2016)... ... May 02, 2016 , ... The Civilian Corps of the ... the civilian nurses that care for its uniformed service members, the retired service members, ... 1974 designating May 6th through May 12th National Nurses Week. It acknowledges the hard ...
(Date:5/2/2016)... WACO, Texas (PRWEB) , ... May 02, 2016 , ... ... Corporation will offer an incentive to people who share their fitness journey on ... footwear and premium first aid products, will award a $100 product voucher each week ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... May 2, 2016 Kalorama Information noted the ... Records) market in a recent white paper.  The healthcare ... physician usage, a growing market are among the top ... Kalorama,s report EMR 2016: The Market for ... seventh complete study of the EMR industry, and the ...
(Date:5/2/2016)... , May 2, 2016  Deerfield announced ... financing of Graybug Vision, Inc. Graybug Vision is ... therapies that may transform care for ocular diseases ... Graybug Vision,s technology was first developed at Johns ... a startup venture. Graybug Vision ...
(Date:5/2/2016)... , May 2, 2016  Celsion Corporation (NASDAQ: ... today announced data from the first cohort of ... trial (the OVATION Study) combining GEN-1, the Company,s ... the treatment of newly-diagnosed patients with advanced ovarian ... interval debulking surgery.  In the first three patients ...
Breaking Medicine Technology: