Navigation Links
60 Million Worldwide Carry Heart Disease Mutation
Date:1/23/2009

Muscle protein variant, most common in India, leaves carriers with little warning of dangers

FRIDAY, Jan. 23 (HealthDay News) -- About 60 million people worldwide carry a gene mutation that almost always causes heart disease, but the mutation is most common among people in India, according to a study by 25 researchers from four countries.

Heart disease is the leading cause of death in the world. By 2010, India will account for about 60 percent of the world's heart disease, said the researchers, who analyzed the DNA of about 800 patients at cardiac centers in India. The study was published in the Jan. 18 issue of Nature Genetics.

The mutation, a deletion of 25 letters of genetic code from the heart protein gene MYBPC3, was discovered five years ago in two Indian families with a history of cardiomyopathy, an enlargement or abnormal thickening of the heart muscle that weakens the heart and reduces its ability to pump blood.

The genetic risk of heart disease is expressed as an odds ratio. A small effect would be 1:2 and a large effect would be 2:0. The researchers said the odds ratio for people with the MYBPC3 mutation is almost off the scale, 7:0. People with the mutation usually have few symptoms until middle age. But after that, most develop symptoms and are at risk for sudden cardiac death.

"The mutation leads to the formation of an abnormal protein. Young people can degrade the abnormal protein and remain healthy, but as they get older, it builds up and eventually results in the symptoms we see," study leader Kumarasamy Thangaraj, Center for Cellular and Molecular Biology in Hyderabad, India, said in a news release issued by the Wellcome Trust Sanger Institute.

The researchers believe the mutation arose about 30,000 years ago in India, and spread because its effects usually develop only after people with the mutation have had children.

"The bad news is that many of these muta
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. HHS Announces $75 Million in Supplemental Funding to States for Pandemic Flu Preparedness
2. AUDIO from Medialink and Pfizer: Number of Uninsured Americans Grows to 47 Million
3. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
4. 1.5 million children could be saved
5. The Philadelphia Walk Now for Autism Expected to Draw 10,000 Walkers and Raise $1 Million to Help Find Answers About the Nations Fastest-Growing Developmental Disorder
6. UVa researcher awarded $3.6 million grant to fight drug-resistant bacteria
7. EaglePicher Corporation Completes Transaction to Sell EaglePicher Boron, LLC to Ceradyne, Inc. for $69 Million
8. R. P. Simmons Family Foundation Pledges $2 Million for New Childrens Hospital of Pittsburgh of UPMC Campus
9. £5 million investment in personalized medicines to cut patient deaths
10. Keane Wins $1 Million Electronic Medical Record (EMR) Implementation at New Jersey-Based Acute Care Facility
11. PainCare Receives $14.4 Million in Cash From Completed Sale of South Florida Ambulatory Surgery Centers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
60 Million Worldwide Carry Heart Disease Mutation
(Date:10/20/2014)... Rockynol Retirement Community broke ground on ... $11 million project will include the latest in Assisted ... full-service restaurant style dining. , “We are excited to ... Living apartments,” said Kara Hanzie, Rockynol Executive Director during ... care and this investment is proof of our commitment.” ...
(Date:10/20/2014)... Unveiled at the Sept. 18 board meeting, The Center for ... ROI on membership dues at 12.5. In other words, for ... value to member hospitals. The calculation used to determine member ... , “This is the first time we’ve actually been able ... is really sound,” said Bill Ryan , president and ...
(Date:10/19/2014)... Hastings and Hastings, a Phoenix personal injury law firm ... Phoenix area and across Arizona reports record demand in ... accidents. Statistics have indicated a steady increase in automobile ... Hastings and Hastings has seen a steady increase in ... been injured through no fault of their own that ...
(Date:10/19/2014)... Having been working in the garment industry for decades, LunaDress’ ... to James, one of the company’s top designers, many ladies ... skirts that add beauty to them. Chiffon floor length outfits ... its new selection of 2014 long prom dresses. , ... are available in over 20 popular designs. The company intends ...
(Date:10/19/2014)... Stephen T. Greenberg, M.D., with offices in Woodbury, Southampton and ... as one of Long Island’s best cosmetic surgeons. In ... the best provider for Botox injections. Glisten, his Skin & ... best Laser Treatment center on Long Island.* , The voting ... the contest once per day, per IP address. , Stephen ...
Breaking Medicine News(10 mins):Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 3Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 4Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 2Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 3Health News:2014 Long Prom Dresses From LunaDress Now Available In Over 20 Popular Designs 2Health News:Dr. Stephen T. Greenberg – Nominated for the 10th Consecutive Year for One of Long Island’s Best Cosmetic Surgeons for 2015 by the Long Island Press 2
... ... how to have fun and go green with your mom on Mother,s Day. , ... (Vocus) April 29, 2010 -- Your mom has taught ... Boldrini, is greening Mother,s Day for us. She says: "The biggest gift your mom wants is ...
... ... fast high capacity transport network by 1.4 milliseconds on the route between Chicago and Newark ... ... today announced the completion of a network improvement project designed to significantly reduce the latency ...
... ... culture fodder is ShoeDini, the As Seen On TV shoe horn with a telescoping ... shoes on and off without having to bend over, the commercial calls a spade ... shoe horn on a stick. Featuring a famously annoying voice, the latest ASOTV item ...
... -- Combination antibiotics effectively treat Chlamydia-induced reactive arthritis a ... a federal multicenter clinical trial led by the University of ... sponsored by the National Institute of Musculoskeletal and Skin Diseases, ... and Rheumatism , a journal of the American College of ...
... less likely to have a varus thrust, but more likely ... visualized during gait as the worsening or abrupt onset of ... return to less varus and more neutral alignment during lift-off ... research has shown that varus thrust seen in gait is ...
... cancer therapeutics based on its next generation oncolytic viruses, ... from HealthCap. With committed capital exceeding 800 million, ... venture capital within life sciences in Europe. After ... strong safety and efficacy results, Oncos has selected its ...
Cached Medicine News:Health News:5 Ways to Have a Green Mother's Day 2Health News:5 Ways to Have a Green Mother's Day 3Health News:Network Latency Improvement Creates One of the Fastest Routes between Chicago and Newark/New York City 2Health News:New Product Has More Than Shtick Appeal It's Not Just a Shoe Horn, It's a Shoe Horn on a Stick 2Health News:Combination antibiotics effective against chlamydia-induced arthritis 2Health News:Combination antibiotics effective against chlamydia-induced arthritis 3Health News:Racial disparity observed in varus and valgus thrust study of knee OA 2
(Date:10/19/2014)... N.Y. , Oct. 19, 2014  Henry Schein, ... provider of health care products and services to office-based ... it has invested in Iwase Dental Supply, Inc., a ... in Japan.  The transaction marks Henry Schein,s entrance into ... largest dental market, and increases to 28 the number ...
(Date:10/17/2014)... N.C. , Oct. 17, 2014 ... the Medical Affairs function has come across several ... resources efficiently and managing globalization.  ... Practices, LLC is dedicated to providing benchmarking and ... Medical Affairs Consortium is a service composed of ...
(Date:10/17/2014)... OAKS, Calif. , Oct. 17, 2014  Amgen ... of R. Sanders Williams , M.D., president of ... Mahley Distinguished Professor.  "We are pleased ... Amgen Board," said Robert A. Bradway , chairman ... and distinguished experience in academic medicine and his direct ...
Breaking Medicine Technology:Henry Schein Enters Japan With Investment in Iwase Dental Supply 2Henry Schein Enters Japan With Investment in Iwase Dental Supply 3Henry Schein Enters Japan With Investment in Iwase Dental Supply 4Henry Schein Enters Japan With Investment in Iwase Dental Supply 5Early Key Findings from the Medical Affairs Consortium Research 2Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 2Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 3
... 12 ,Micromet, Inc. (Nasdaq: MITI ) and ... treatment in a multi-center, phase 2 trial conducted ... adult acute lymphoblastic leukemia (ALL). Blinatumomab is a ... is only expressed,on B cells. The clinical development ...
... June 11 /Xinhua-PRNewswire-FirstCall/ --,Pharmaceutical company Pharmaxis (ASX: PXS; ... III clinical trial evaluating the safety of,Bronchitol in ... 12-month treatment period was an open label extension ... reported, showing that Bronchitol,improved quality of life and ...
Cached Medicine Technology:Micromet and MedImmune Commence Treatment in Phase 2 Trial of BiTE Antibody Blinatumomab (MT103/MEDI-538) in Patients with Acute Lymphoblastic Leukemia 2Micromet and MedImmune Commence Treatment in Phase 2 Trial of BiTE Antibody Blinatumomab (MT103/MEDI-538) in Patients with Acute Lymphoblastic Leukemia 3Micromet and MedImmune Commence Treatment in Phase 2 Trial of BiTE Antibody Blinatumomab (MT103/MEDI-538) in Patients with Acute Lymphoblastic Leukemia 4Micromet and MedImmune Commence Treatment in Phase 2 Trial of BiTE Antibody Blinatumomab (MT103/MEDI-538) in Patients with Acute Lymphoblastic Leukemia 5Micromet and MedImmune Commence Treatment in Phase 2 Trial of BiTE Antibody Blinatumomab (MT103/MEDI-538) in Patients with Acute Lymphoblastic Leukemia 6Pharmaxis Long-Term Safety Study of Bronchitol Completes 2
... The complete line of Surgical Access ...unlike ... ,The OnePort™ trocar system is actually four ... versatile, operationally flexible and clinically adaptive to ... options in disposability and bladed or dilating ...
... Surgical Access ...unlike any trocar system you've ... is actually four systems in one ... clinically adaptive to all of your needs., ... bladed or dilating tip styles, OnePort™ can ...
... Surgical Access ...unlike any trocar system you've ... is actually four systems in one ... clinically adaptive to all of your needs., ... bladed or dilating tip styles, OnePort™ can ...
... Pak contains: (1) 15mm obturator, ... (1) 12mm ENDOPATH thoracic trocar ... Pak contains: (1) 15mm obturator, ... ,FPK03 Thoracic Trocar Pak contains: ...
Medicine Products: