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5 genetic variations increase risk of ovarian cancer
Date:3/27/2013

cer screening and prevention strategies directed towards women most likely to benefit."

"Our hope is that these genetic variants, along with established epidemiologic factors, such as reproductive history, will not only enhance our ability to predict which women are at increased risk for developing this highly fatal disease, but will also provide new insight into the underlying biology and pathogenesis of ovarian cancer," said epidemiologist Joellen Schildkraut, PhD, director of the Cancer Control and Population Sciences program at Duke Cancer Institute. She is a senior coauthor of one of the Nature studies and the principal investigator of the North Carolina Ovarian Cancer Study, one of the studies that contributed data to this discovery.

"Because of the large number of study subjects, we were able to determine that some genetic variants were important to specific subgroups of ovarian cancer, suggesting possible differences in the underlying cause of these subtypes," Schildkraut said.

Additional studies on the biology of these genetic variants could help researchers develop new tests to predict which women are at risk of developing ovarian cancer, and potentially lead to therapies that better treat the disease.


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Contact: Rachel Harrison
rachel.harrison@duke.edu
919-419-5069
Duke University Medical Center
Source:Eurekalert

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