Navigation Links
5 genetic variations increase risk of ovarian cancer
Date:3/27/2013

DURHAM, N.C. -- An international research collaboration has found five new regions of the human genome that are linked to increased risks for developing ovarian cancer. Duke Medicine researchers played a leading role analyzing genetic information from more than 40,000 women.

The findings are published in four studies, two appearing in the journal Nature Communications and two in Nature Genetics on March 27, 2013. The research is being published as part of a coordinated release of new data from the Collaborative Oncological Gene-environment Study (COGS), an international effort to identify genetic variations that make certain people susceptible to developing breast, prostate and ovarian cancers.

According to the National Cancer Institute, ovarian cancer accounts for 3 percent of all cancers in women and is the leading cause of death among cancers of the female reproductive system. This is due to the lack of early symptoms or effective screening tests.

Inherited mutations in the BRCA1 and BRCA2 genes dramatically increase ovarian cancer risk. Genetic testing for BRCA1 and BRCA2 mutations can identify women who would benefit most from surgery to prevent ovarian cancer, but this is relevant to less than 1 percent of the population. Other genetic variants that are more common may also affect ovarian risk. The Ovarian Cancer Association Consortium previously described six such genetic differences and now the COGS project has found five more.

"Because ovarian cancer is relatively uncommon, it is critically important to identify subsets of women at increased risk," said senior coauthor Andrew Berchuck, MD, director of the division of gynecologic oncology at Duke Cancer Institute. "Although the common genetic risk variants for ovarian cancer discovered thus far are not strong enough to use in practice, this may become a reality as additional variants are discovered. This could facilitate development of ovarian can
'/>"/>

Contact: Rachel Harrison
rachel.harrison@duke.edu
919-419-5069
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Almost Nuts! Supports Whole Foods Decision on Banning Gentically Modified Salmon and Continues to Support the Movement Against Genetically Engineered Foods
2. Fertility & Genetics Announces Fertility Education Seminars & IVF Cycle Giveaway
3. Genetic risk strategies needed for young, black, female breast cancer patients, Moffitt study shows
4. For the first time, recommendations offer guidance about incidental genetic findings
5. Genetics, age and ethnicity are risk factors in PCa, say experts
6. TGen researcher leads distinguished international panel at genetics conference in Phoenix
7. Genetics May Be Tied to Breast Cancer Risk in Unexpected Ways
8. Genetic testing may be used to identify BPH patients with increased risk of prostate cancer
9. UK study: Epigenetic changes play a key role in development of chemo resistance in BCa
10. Geneticist Mary-Claire King receives the 2013 Paul Ehrlich Prize
11. Study finds fat and bone mass are genetically linked
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... New York, New York (PRWEB) September 17, 2014 ... ) filings involving the Conserve line of metal-on-metal ... litigation now underway in U.S. District Court, Northern ... to an updated Case List issued by the ... 15, 2014, at least 397 product liability claims ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 The Food ... today, September 17, 2014, to consider: , ... Therapy (TRT), and, 2. The potential ... , With the TRT litigation ongoing, an informally-organized litigation ... the dangers of testosterone replacement therapy. Among others, ZKB ...
(Date:9/17/2014)... StartX , a nonprofit technology accelerator ... of funding at its Summer Demo Day yesterday. The ... was the first such gathering held at StartX’s new, ... The presentations were delivered on an expansive stage built ... 2,000 square foot life science facility that opened last ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 Cadiz ... treatments and cosmetic procedures to clients throughout Central ... of services is Collagen Induction Therapy. Using the ... are able to help clients correct a wide ... introduced this month, and Cadiz Laser Spa is ...
(Date:9/17/2014)... -- Present-day Europeans are the descendants of at ... a new study. Previous research suggested ... European farmers. But, a new genetic analysis involving ... descendants of Ancient North Eurasians. Nearly all present-day ... group, researchers from Harvard Medical School said. , ...
Breaking Medicine News(10 mins):Health News:Wright Hip Lawsuit News: Nearly 400 Filings Reported in Federal Wright Conserve Hip Replacement Litigation, Bernstein Liebhard LLP Reports 2Health News:Wright Hip Lawsuit News: Nearly 400 Filings Reported in Federal Wright Conserve Hip Replacement Litigation, Bernstein Liebhard LLP Reports 3Health News:FDA Advisory Committee Holds Hearing on Testosterone Safety 2Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 2Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 3Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 4Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 5Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 6Health News:Revolutionary Collagen Induction Therapy is Now Available at Cadiz Laser Spa 2Health News:Europeans Are Descendants of at Least 3 Ancient Human Groups: Study 2Health News:Europeans Are Descendants of at Least 3 Ancient Human Groups: Study 3
... no health insurance don,t see a doctor all year ... children share at least one frightening fact: If they are ... health care... period. , New research from the University ... children in families earning between $38,000 and $77,000 annually who ...
... Universitys Slone Epidemiology Center have found that approximately one ... and cold medications during a given week. These ... Academic Societies & Asian Society for Pediatric Research Joint ... medications are widely marketed in the U.S. but surprisingly ...
... Two new studies conducted by researchers at Cincinnati Childrens ... parental job loss on childrens healthcare and the importance ... healthcare needs and reduce healthcare disparities. , The studies ... meeting of the Pediatric Academic Societies in Honolulu. , ...
... Calif., May 2 The following is,being issued ... protect,Kaiser facilities will launch an unfair labor practice ... Tuesday, May 6. This is the,first-ever group of ... and spied on workers who were trying to ...
... JUROR MISCONDUCT, LITTLE ROCK, Ark., May 2 ... suing Arkansas Children,s Hospital,over a wrong sided brain surgery ... "We have concerns about the accuracy of statements made ... has been a possibility of,juror misconduct," said attorney Phillip ...
... immunotherapy technique to help prevent the progression from ... simple, cost-effective technique are published May 2nd in ... an overwhelming need for effective immunotherapies for HIV, ... highly toxic. The authors, led by Professor ...
Cached Medicine News:Health News:Middle Class Uninsured Kids' Health Risk Almost as High as Poor Children's 2Health News:1 in 10 children using cough, cold medications 2Health News:US unemployment having impact on kids' health-care coverage -- and that puts their health at risk 2Health News:First-Ever Group of Hospital Security Officers to Strike over Unfair Labor Practices, Walk out of Facilities Across California on May 6 2Health News:Wrong-Sided Brain Surgery Trial Halted 2
(Date:9/17/2014)... Sept. 17, 2014 /PRNewswire-iReach/ -- ChemImage announced ... discussing improvements in the development of imaging ... both normal and diseased tissue that minimizes ... surgical procedures, lowers surgical costs and potentially ... The clinical and scientific ...
(Date:9/17/2014)... Minn. , Sept. 17, 2014 ACIST ... global market leader of advanced imaging modalities for cardiology, ... System in two live cases at the Transcatheter Cardiovascular ... The cases were presented from Medstar Washington Hospital Center ... Hospital/Columbia University Medical Center ( New York, NY ...
(Date:9/17/2014)... 17, 2014  Millions of people suffer from neck and ... Recently the FDA approved the launch of a ... implant device developed by Spinal Kinetics, which may offer relief ... or arm pain. Hospital for Special Surgery (HSS), the number ... in New York City and in ...
Breaking Medicine Technology:Patient Outcomes Improve When Molecular Chemical Imaging Technology Is Used to Aid Robotic Surgical Procedures, According to New White Paper 2ACIST Launches HDi High-Definition IVUS 2ACIST Launches HDi High-Definition IVUS 3Cervical Disc Clinical Trial for People with Neck and Arm Pain Set to Begin at Hospital for Special Surgery 2
... Fenwal, Inc., a global medical technology company focused on ... names of 16 inspiring individuals inducted into the company,s 2010 ... than a decade, Fenwal has partnered with blood centers to ... in assuring medicine,s most vital natural resource -- blood -- ...
... Systems (NYSE: VAR ) today announced the execution ... to supply medical imaging subcomponents to Toshiba Medical Systems for ... will be booked over the period of the agreement. ... it marks the latest chapter in our 30+ year relationship ...
Cached Medicine Technology:2010 Inductees to the Fenwal Blood Donation Hall of Fame 22010 Inductees to the Fenwal Blood Donation Hall of Fame 3Varian Medical Systems Announces X-Ray Products Contract With Toshiba Medical Systems 2
ENDOlap™ laparoscopes provide excellent image linearity and flatness of field....
Inquire...
The Fujinon's R410 laparoscope is the first to bring a 410,000 pixel CCD to the end of the scope. Superior imaging and color replication, along with a unique lens washing capability make the R410 the...
ACMI™ Distortion-Free Laparoscopes utilize technical advances in optical lens design to provide images without the fish-eye effect typically found on the peripheral viewing edges of conventional...
Medicine Products: