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5 big strides to fight lung disease in our tiniest patients
Date:12/3/2012

e effect on the lungs when injected into the lungs as they were put on oxygen.
  • MSCs had a reparative effect when injected two weeks after being on oxygen.
  • When conditioned media a cell-free substance produced by MSCs was administered instead of MSCs, it was found to have the same protective and reparative effects as the stem cells.
  • When examined after six months (the equivalent of 40 human years), treated animals had better exercise performance and persistent benefit in lung structure.
  • MSCs did not adversely affect the long-term health of normal rats. One of the concerns about stem cells is that by promoting cell growth, they may cause cancerous growth. To address this question, Dr. Thbaud gave MSCs to a control group that was not treated with oxygen. When examined after six months, these animals were normal and healthy.
  • Within two years, Dr. Thbaud wants to be talking about a pilot study with 20 human patients showing that this stem-cell therapy is feasible and safe, and in four years he wants to embark on a randomized control trial. These are all steps in his profound desire to help the babies he sees in the NICU with BPD, and he is confident a treatment will be developed.

    "It's going to happen here in Ottawa, but for babies worldwide," says Dr. Thbaud.


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    Contact: Paddy Moore
    padmoore@ohri.ca
    613-737-8899 x73687
    Ottawa Hospital Research Institute
    Source:Eurekalert  

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