Navigation Links
5 big strides to fight lung disease in our tiniest patients
Date:12/3/2012

December, 4, 2012 Ottawa For Ottawa scientist and neonatologist Dr. Bernard Thbaud, even a major paper that answers five significant questions still doesn't seem quite enough in his determined path to get his laboratory breakthrough into the neonatal intensive care unit (NICU). Dr. Thbaud's proposed therapy would use stem cells from umbilical cords to treat a disease previously thought to be untreatable bronchopulmonary dysplasia, or BPD.

"BPD is a lung disease described 45 years ago in which we have made zero progress. And now, with these cord-derived stem cells there is a true potential for a major breakthrough," says Dr. Thbaud, a senior scientist at the Ottawa Hospital Research Institute and CHEO Research Institute, a neonatologist at CHEO and The Ottawa Hospital, and a professor in the Faculty of Medicine at the University of Ottawa.

"I am confident that we have the talent and the tools here at CHEO and OHRI to find a treatment for BPD. These findings published today are helping us get there," continues Thbaud.

BPD affects approximately 10,000 very premature newborns in Canada and the U.S. every year. The lungs of these infants are not developed enough to sustain them, so they must receive oxygen through a breathing machine. However, this combination of mechanical ventilation and oxygen damages the lungs and stops their development. In addition, longer stays in the NICU for these extremely premature babies affect the normal development of other parts of the body, including the retina, the kidneys and the brain.

Today in the journal Thorax, Dr. Thbaud's team provides significant findings in experiments with newborn rats given oxygen. The lung development of a newborn rat mimics that of a premature baby born at 24 weeks. The five major findings reported in Thorax are:

  1. Stem cells called mesenchymal stromal cells (MSCs) from a human umbilical cord (not the blood) have a protective effect on the lungs when injected into the lungs as they were put on oxygen.
  2. MSCs had a reparative effect when injected two weeks after being on oxygen.
  3. When conditioned media a cell-free substance produced by MSCs was administered instead of MSCs, it was found to have the same protective and reparative effects as the stem cells.
  4. When examined after six months (the equivalent of 40 human years), treated animals had better exercise performance and persistent benefit in lung structure.
  5. MSCs did not adversely affect the long-term health of normal rats. One of the concerns about stem cells is that by promoting cell growth, they may cause cancerous growth. To address this question, Dr. Thbaud gave MSCs to a control group that was not treated with oxygen. When examined after six months, these animals were normal and healthy.

Within two years, Dr. Thbaud wants to be talking about a pilot study with 20 human patients showing that this stem-cell therapy is feasible and safe, and in four years he wants to embark on a randomized control trial. These are all steps in his profound desire to help the babies he sees in the NICU with BPD, and he is confident a treatment will be developed.

"It's going to happen here in Ottawa, but for babies worldwide," says Dr. Thbaud.


'/>"/>

Contact: Paddy Moore
padmoore@ohri.ca
613-737-8899 x73687
Ottawa Hospital Research Institute
Source:Eurekalert  

Related medicine news :

1. Colorful Fruits, Vegetables May Be Key to Cancer-Fighting Diet
2. University of Tennessee study: Unexpected microbes fighting harmful greenhouse gas
3. Virtual reality could help people lose weight, fight prejudice
4. New bacteria to fight against intestinal inflammation
5. Could Cholesterol Treatment Fight Repeat Heart Attack?
6. Recent findings may help to fight melanomas resistance to chemotherapy
7. Short Bursts of Intense Exercise Can Fight Weight Gain: Study
8. Tissue around tumor holds key to fighting triple negative breast cancer
9. FEMA awards $1 Million to WPI to develop groundbreaking toxic gas sensors for firefighters
10. Mayo Clinic researchers identify new enzyme to fight Alzheimers disease
11. An advance toward a flu-fighting nasal spray
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
5 big strides to fight lung disease in our tiniest patients
(Date:2/19/2017)... ... February 19, 2017 , ... Orbita, ... join forces with Healthwise ® at HIMSS 2017 to showcase ... in evidence-based health education, technology and services, will demonstrate a voice-powered knowedge assistant ...
(Date:2/18/2017)... , ... February 17, 2017 , ... Park Cities Pet ... Behave” Show on the Pet Life Radio network. The episode, which was posted ... of topics including: what factors led to Park Cities Pet Sitter’s being awarded the ...
(Date:2/17/2017)... ... February 17, 2017 , ... The Alliance Healthcare Foundation ... to further positively impact the health and wellness of our community in San ... our duty to seriously consider releasing our assets beyond our 5% targeted distribution ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... Prevent a Warning Letter, **An FDAnews Webinar**, Feb. 23, 2017 — 1:30 p.m. ... distinguish between corrective action (CA) and preventive action (PA)? , The methods share ...
(Date:2/17/2017)... ... February 17, 2017 , ... Pharmica Consulting attended CHI's ... facets of clinical trial planning and management. Pharmica discussed the importance of effective ... addition, attendees stopping by Pharmica’s booth were able to demo its cloud-based ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... , Feb. 16, 2017 Absorption Systems, a ... medical devices, is pleased to announce that its Chief ... selected as a winner of the 2017 Executive Management ... and recognizes driven executives for their creative management ... The awards ceremony and celebration is on March 8, ...
(Date:2/16/2017)... Ontario , Feb. 16, 2017  Aralez Pharmaceuticals ... global specialty pharmaceutical company, today announced that executive management ... Conference to be held February 22-23, 2017. Adrian ... of the Company at 1:35 p.m. local time on ... and audio archive for the event may be accessed ...
(Date:2/16/2017)... NEW YORK , Feb. 16, 2017 ... and agreements entered into by the worlds leading healthcare companies. ... Description The Global ... access to partnering deals and agreements entered into by the world,s ... - Top deals by value - Deals listed by ...
Breaking Medicine Technology: