Navigation Links
5 big strides to fight lung disease in our tiniest patients
Date:12/3/2012

December, 4, 2012 Ottawa For Ottawa scientist and neonatologist Dr. Bernard Thbaud, even a major paper that answers five significant questions still doesn't seem quite enough in his determined path to get his laboratory breakthrough into the neonatal intensive care unit (NICU). Dr. Thbaud's proposed therapy would use stem cells from umbilical cords to treat a disease previously thought to be untreatable bronchopulmonary dysplasia, or BPD.

"BPD is a lung disease described 45 years ago in which we have made zero progress. And now, with these cord-derived stem cells there is a true potential for a major breakthrough," says Dr. Thbaud, a senior scientist at the Ottawa Hospital Research Institute and CHEO Research Institute, a neonatologist at CHEO and The Ottawa Hospital, and a professor in the Faculty of Medicine at the University of Ottawa.

"I am confident that we have the talent and the tools here at CHEO and OHRI to find a treatment for BPD. These findings published today are helping us get there," continues Thbaud.

BPD affects approximately 10,000 very premature newborns in Canada and the U.S. every year. The lungs of these infants are not developed enough to sustain them, so they must receive oxygen through a breathing machine. However, this combination of mechanical ventilation and oxygen damages the lungs and stops their development. In addition, longer stays in the NICU for these extremely premature babies affect the normal development of other parts of the body, including the retina, the kidneys and the brain.

Today in the journal Thorax, Dr. Thbaud's team provides significant findings in experiments with newborn rats given oxygen. The lung development of a newborn rat mimics that of a premature baby born at 24 weeks. The five major findings reported in Thorax are:

  1. Stem cells called mesenchymal stromal cells (MSCs) from a human umbilical cord (not the blood) have a protective effect on the lungs when injected into the lungs as they were put on oxygen.
  2. MSCs had a reparative effect when injected two weeks after being on oxygen.
  3. When conditioned media a cell-free substance produced by MSCs was administered instead of MSCs, it was found to have the same protective and reparative effects as the stem cells.
  4. When examined after six months (the equivalent of 40 human years), treated animals had better exercise performance and persistent benefit in lung structure.
  5. MSCs did not adversely affect the long-term health of normal rats. One of the concerns about stem cells is that by promoting cell growth, they may cause cancerous growth. To address this question, Dr. Thbaud gave MSCs to a control group that was not treated with oxygen. When examined after six months, these animals were normal and healthy.

Within two years, Dr. Thbaud wants to be talking about a pilot study with 20 human patients showing that this stem-cell therapy is feasible and safe, and in four years he wants to embark on a randomized control trial. These are all steps in his profound desire to help the babies he sees in the NICU with BPD, and he is confident a treatment will be developed.

"It's going to happen here in Ottawa, but for babies worldwide," says Dr. Thbaud.


'/>"/>

Contact: Paddy Moore
padmoore@ohri.ca
613-737-8899 x73687
Ottawa Hospital Research Institute
Source:Eurekalert  

Related medicine news :

1. Colorful Fruits, Vegetables May Be Key to Cancer-Fighting Diet
2. University of Tennessee study: Unexpected microbes fighting harmful greenhouse gas
3. Virtual reality could help people lose weight, fight prejudice
4. New bacteria to fight against intestinal inflammation
5. Could Cholesterol Treatment Fight Repeat Heart Attack?
6. Recent findings may help to fight melanomas resistance to chemotherapy
7. Short Bursts of Intense Exercise Can Fight Weight Gain: Study
8. Tissue around tumor holds key to fighting triple negative breast cancer
9. FEMA awards $1 Million to WPI to develop groundbreaking toxic gas sensors for firefighters
10. Mayo Clinic researchers identify new enzyme to fight Alzheimers disease
11. An advance toward a flu-fighting nasal spray
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
5 big strides to fight lung disease in our tiniest patients
(Date:2/9/2016)... ... 09, 2016 , ... United Methodist Communications collaborated with Chocolate ... animated video designed to prevent the next widespread Ebola outbreak from ... being distributed throughout Togo, Liberia, Sierra Leone, Nigeria, Côte d’Ivoire and other African ...
(Date:2/9/2016)... ... February 09, 2016 , ... i2i Systems, an early innovator and developer ... vendors in the latest KLAS report, Population Health Management 2015: How Far Can Your ... for population health management (PHM). The latest KLAS Report, leveraging over 200 user ...
(Date:2/9/2016)... ... February 09, 2016 , ... The Brain Preservation Foundation’s ... team from 21st Century Medicine (21CM) ( http://www.21cm.com/ ), spearheaded by recent ... circuits of an intact rabbit brain for extremely long-term storage using a combination ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... launched its newly redesigned website, federallabs.org . The site houses a wealth ... license available federal technologies through the process called technology transfer (T2). As a ...
(Date:2/8/2016)... ... February 08, 2016 , ... Coast Dental has a new way to help ... Month and family dentist Yvonne Dorrian, DMD, is hosting a free seminar on Friday, ... next to Target at 1207 North Peachtree Parkway in Peachtree City. Dr. Dorrian will ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... , Feb. 9, 2016  Increasingly, health care professionals ... vital signs with wireless technology. With the Vios Monitoring ... patient oversight and remotely detect problems before they become ... across in-hospital environments. the United States ... States . --> The Vios ...
(Date:2/9/2016)... , Feb. 9, 2016  Johnson & Johnson (NYSE: ... Markets Global Healthcare Conference on Tuesday, Feb. 23, at ... Dominic Caruso , Vice President, Finance & Chief Financial ... will represent the Company in a session scheduled at ... --> www.investor.jnj.com . --> This ...
(Date:2/9/2016)... and HONG KONG , Feb. 9, 2016 ... , PhD, has joined Athenex as Vice President of Corporate ... Raymond Yeung , MSc, MBA has joined as Senior Director ... Hong Kong . Simon Pedder ... that I have known for a while. Coupled together with ...
Breaking Medicine Technology: