5 Brown faculty elected to world's largest scien...(has served as executive director of the ...),Health

In a Nature paper (March 2002), Donoghue reported that a computer could use a reconstructed brain signal to accomplish immediate, complex goal-directed behavior. A device based on his research entered clinical trials on human subjects in April 2004, results of which were reported at the annual meeting of the American Academy of Physical Medicine and Rehabilitation in Phoenix that fall.

For more than 20 years, Donoghue has performed research on brain-computer interfaces, and his laboratory is internationally recognized as a leader in this field. His research has been funded by the National Institutes of Health (NIH), the National Science Foundation (NSF), and the Defense Advanced Research Projects Agency (DARPA), as well as private foundations.

Gerbi is the George Eggleston Professor of Biochemistry in the Division of Biology and Medicine at Brown, where she teaches molecular cell biology.

She was recognized for her ongoing research. Her lab is studying the initiation of DNA replication (doubling of the hereditary information of the cell), and has devised a method to map the start site of DNA replication at the nucleotide level. Her research in progress suggests that a steroid hormone receptor may play a direct role for initiation of DNA replication, which could help clarify the role certain hormones play in some cancers.

The Gerbi lab also studies the structure, evolution and biogenesis of ribosomes (the factories in the cell that make proteins), and her lab's work has opened the possibility for a new class of antibiotics.

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