Navigation Links
4 possible risk factors for ovarian cancer found
Date:9/19/2010

ROCHESTER, Minn. -- A consortium of cancer researchers has identified four chromosome locations with genetic changes that are likely to alter a woman's risk of developing ovarian cancer. The findings appear in Nature Genetics in an article authored by a Mayo Clinic researcher.

Researchers say that while more needs to be learned about the function of the specific chromosomal regions involved in susceptibility, the discoveries move them a major step closer to individualized risk assessments for ovarian cancer. In the future, women at greatest risk due to these and other inherited changes may be offered increased surveillance or preventive measures.

"In searching the genome, we came up with some surprises on chromosomes 2, 3, and 17," says Ellen Goode, Ph.D., Mayo Clinic genetic epidemiologist and lead author. "While examining the usual suspects in a region on chromosome 8, we found that SNPs associated with ovarian cancer risk were located quite a distance away from those associated with risk of other cancers, which suggest that they may act through a different mechanism." SNPs, single nucleotide polymorphisms, are common genetic variants associated, in this case, with cancer risk.

The findings come from a large genome-wide association study (GWAS) that spanned three continents. Following an initial study in over 1,700 cases, the researchers followed up with a study of over 24,000 women. They narrowed the focus to nine regions and confirmed that three loci (locations on the chromosome) were much stronger than the others and a fourth "approached genome-wide significance." These particular loci are associated with serous ovarian cancer, the most aggressive and common of the four main types of the disease.


'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1

Related medicine news :

1. FDA Chief Says More Egg Recalls Possible
2. UC San Diego researchers find cause of metabolic disease -- and possible cure
3. Intensively lowering glucose: Possible benefits must be weighed against risks
4. International liver cancer congress provides possible solutions to reduce significant burden
5. Study shows a possible link between preschoolers cavities and excess body fat
6. Possible link between sleep-disordered breathing and cardiovascular disease revealed
7. Online Housecalls, Improved Patient Care and Increased Communication Between Doctors and Healthcare Professionals Now Made Possible Through Docgreet.com
8. Breast Cancer Vaccine Possible, Scientists Say
9. Complicated Surgeries Carry Greater Risks, Possible Need for New York Medical Malpractice Attorneys According To David Perecman
10. Some bisphosphonates users unfamiliar with drugs possible side effects on oral health
11. Novel RNA interference screening technique identifies possible path for malignant glioma treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... 29, 2014 Gummy smile surgeon , ... dark gums treatments that can enhance and perfect gummy smiles ... appearance that displays the teeth to their best advantage. Some ... or have gums that are dark or discolored. Patients with ... self-conscious about their smiles or experience a high level of ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 On July 28, ... McElwee is a member of the band Fowler’s Mustache ... as how the band came up with their name. At ... most interesting topics with every band is how they formed ... story is unique so what is the Fowler’s Mustache story?” ...
(Date:7/29/2014)... HealthDay Reporter , MONDAY, July 28, 2014 (HealthDay News) -- ... don,t run, according to new research. But, the best ... reap this benefit even if you run at slow speeds for ... may not need to run a lot to get health benefits," ... Iowa State University. "I hope this study can motivate more people ...
(Date:7/29/2014)... stem-cell discovery might one day lead to a more streamlined ... used in the development of replacement tissue for failing body ... findings in the current edition of Cell . , ... cells back to an embryonic state in which they again ... , The efficiency of this process may soon increase thanks ...
(Date:7/29/2014)... According to an article in the ... from a 52 year old woman in India. The surgery ... reportedly had no idea that she had such a large ... breathlessness for years, but did not connect it to a ... discovered the massive uterine fibroid after Latha was admitted for ...
Breaking Medicine News(10 mins):Health News:Gummy Smile Surgeon, Dr. Alex Farnoosh, Now Offers Procedures to Improve Gummy Smiles and Dark Gums 2Health News:My Positive Perspective Broadcasts Episode with Thomas McElwee of the Band Fowler’s Mustache 2Health News:Running Could Add 3 Years to Your Lifespan 2Health News:Running Could Add 3 Years to Your Lifespan 3Health News:Stem cell advance may increase efficiency of tissue regeneration 2Health News:Stem cell advance may increase efficiency of tissue regeneration 3Health News:World’s Largest Uterine Fibroid Removed from Patient 2Health News:World’s Largest Uterine Fibroid Removed from Patient 3
... Delhi went on mass casual leave Monday, joining ... the sufferings of patients. ,The majority of ... University College of Medical Sciences (UCMS) and Safdarjung ... resentment against the government decision to implement 27 ...
... zero alcohol quotient is highly conducive for the cognitive ... research has suggested//. Infact, even moderated alcohol intake during ... unborn child. ,The study conducted by the University ... Washington, has shown that those children, whose mothers had ...
... over 3500 and an incalculable number of people injured after ... cope with the injured and the dead. ,The quake ... city of Yogyakarta which is near the southern coast of ... left the city in shambles, cutting off communications and road ...
... American study conducted by Arthur Krigsman, of New York ... links to autism//. MMR inoculation is given to young ... But recently there have been claims that the vaccine ... fall in the MMR vaccine uptake rate which has ...
... the world and it has drastically affected the sales of chicken ... for chicken// and the sales are slowly picking up in the ... stage. ,Mohamed Al Shafei, director of the General Union ... great deal in the past with a large number of chickens ...
... very similar to the technology in the United States, and ... for filling up nursing vacancies. With India also being rated ... are realizing their dream of seeking greener pastures. , ... from India who will be joining the hospital during this ...
Cached Medicine News:Health News:Mass Leave By Doctors Leaves Patients Helpless 2Health News:Indonesian Earthquake – Story of Destruction, Death and Disease 2
(Date:7/29/2014)... 2014  The Healthcare Analytics Summit 2014 ... Salt Lake City , Sept. 24-25 has ... healthcare organizations in the U.S. and beyond.  HAS ,14, ... conference devoted to providing immersive learning experiences on ... both accountable care initiatives and population health managemen ...
(Date:7/29/2014)... IRVING, Texas , July 29, 2014 /PRNewswire/ ... three new web-based applications with breakthrough interactive features ... and workflows for members of Children,s Hospital Association.  ... under the Novation Optimize Solutions umbrella – Value ... of how Novation helps organizations address the most ...
(Date:7/29/2014)... July 29, 2014   Abide Therapeutics ... to its board of directors. Thornberry was ... and Endocrinology for Merck & Co. Inc., where ... pipeline management in diabetes, osteoporosis, fertility and contraception. ... the program that resulted in the discovery of ...
Breaking Medicine Technology:Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 2Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 3Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 4Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 5Breakthrough Novation Applications Empower Children's Hospital Association Members to Lower Costs, Increase Quality 2Breakthrough Novation Applications Empower Children's Hospital Association Members to Lower Costs, Increase Quality 3Breakthrough Novation Applications Empower Children's Hospital Association Members to Lower Costs, Increase Quality 4Breakthrough Novation Applications Empower Children's Hospital Association Members to Lower Costs, Increase Quality 5Abide Therapeutics Appoints Nancy Thornberry to Board of Directors 2Abide Therapeutics Appoints Nancy Thornberry to Board of Directors 3
... fully automated clinical chemistry analyser. It leads ... many features only seen previously on larger, ... on board reagent refrigeration and barcoding of ... can accommodate up to 40 reagent bottles, ...
Inquire...
... Lead System (Model 3830) is the worlds ... design allows for flexibility and a smaller ... thickness. The SelectSecure lead system utilizes a ... lead in select locations in either the ...
... Renin, a protease secreted by ... in the renin-angiotensin system. The renin-angiotensin ... water and electrolyte retention by the ... to several factors including decreased intravascular ...
Medicine Products: