Navigation Links
4-in-1
Date:5/7/2009

This release is available in German.

Diagnosis and treatment in one go: Korean researchers led by Tae Gwan Park and Jinwoo Cheon have developed the basis for a four-in-one agent that can detect, target, and disable tumor cells while also making them macroscopically and microscopically visible. As they report in the journal Angewandte Chemie, their work involves magnetic iron oxide particles with a fluorescence dye, RNA fragments, and a special peptide attached. The peptide is present to specifically identify the cancer cells; the RNA fragments suppress the special cancer-cell genes, killing the cells. The magnetic particles act as a contrast agent for magnetic resonance imaging, and the fluorescence dye allows for microscopic imaging of the target cells.

In order to build a protein according to the genetic information in a cell, the gene on the DNA is read off and translated into a "stencil", mRNA, which is then used by the cell as a blueprint for the protein. The mRNA is a good point of attack to stop the synthesis of proteins required for tumor growth. To achieve this, siRNAs (small interfering RNAs) are introduced into the cell. These are short, double-stranded RNA fragments that bind specifically to the target mRNA. Inside the cell, a special protein complex binds to the siRNA, which unwinds and cleaves the mRNA. In this unprotected form, the mRNA is rapidly degraded by the cell.

When bound to nanoparticles, the siRNAs are easier to slip into cells. In order to specifically target cancer cells, the particles carry a short peptide, called RGD, which points the way: RGD strongly binds to an integrin, a membrane protein that is anchored to metastasizing tumor cells in much higher amounts than in healthy tissue. The integrins with RGD-equipped nanoparticles are actively brought into the cell interior with their cargo intact (receptor-media
'/>"/>

Contact: Jinwoo Cheon
jcheon@yonsei.ac.kr
82-221-235-631
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... ... September 01, 2015 , ... Curly Hair ... hair salons. This highly anticipated partnership between Curly Hair Solutions™ and Trade Secrets ... Founder Jonathan Torch and the Curly Hair Solutions™ team could not be more ...
(Date:8/31/2015)... (PRWEB) , ... August 31, 2015 , ... Sculpted Contours ... of Atlanta’s Women of Power and Influence by Modern Luxury’s The Atlantan Magazine. ... the business as well as Kathy King. Her idea and vision to bring ...
(Date:8/31/2015)... ... August 31, 2015 , ... When it comes to undergoing a hair transplant, most patients ... head. Adding more volume to the hair on top of the scalp, as well ... a good amount of donor hair on other areas of their head. , What about ...
(Date:8/31/2015)... , ... August 31, 2015 , ... ... weight management program that is unique to the Lake Orion area. This program ... Macomb County. , WEmovestrong’s weight management program will incorporate group fitness and ...
(Date:8/31/2015)... ... 31, 2015 , ... Coast Dental Vista is celebrating its recent ... to 3 p.m. near Albertsons in the Foothill Center, located at 1279 E. Vista ... and Dr. Jay Lopp. Call (760) 208-2518 for more details or stop by on ...
Breaking Medicine News(10 mins):Health News:Curly Hair Solutions™ Partners With Trade Secrets 2Health News:Sculpted Contours Owner Selected One of Atlanta's Women of Power and Influence by Modern Luxury's The Atlantan Magazine 2Health News:Sculpted Contours Owner Selected One of Atlanta's Women of Power and Influence by Modern Luxury's The Atlantan Magazine 3Health News:Body Hair Transplants to Help Achieve a Full Head of Hair 2Health News:Discover How to Replace Missing Teeth, Reduce Cavities, and Restore Oral Health During Coast Dental’s Open House in Vista, CA on Sept. 5, 2015 2Health News:Discover How to Replace Missing Teeth, Reduce Cavities, and Restore Oral Health During Coast Dental’s Open House in Vista, CA on Sept. 5, 2015 3
... ... of Africa.,A Virtual Soccer Ball Created by I Imagine Studio To Be Signed by Thousands, ... ... Rotary’s campaign to eradicate the disease, I Imagine Studio has created an interactive, strategic viral ...
... ... premium library of photographs documenting real people and their emotions. Created by assignment photographers ... ) is one of the first stock photo agencies devoted solely to portraiture of ... ...
... ... ... 20, 2010 -- IT-Lifeline, the Northwest’s foremost provider of disaster recovery and business continuity ... that they have entered into a joint marketing agreement to provide a suite of ...
... with erlotinib for people with non-small-cell form of disease ... people with non-small-cell lung cancer, treatment with the drug ... rates, a new study suggests. , Non-small-cell lung ... cases. About half the time, people have advanced disease ...
... THURSDAY, May 20 (HealthDay News) -- Walk a little, and your ... thank you. , That,s the message of a new study that ... of an extremely common condition known as metabolic syndrome, which can ... shows a connection between more walking and better health -- it ...
... ... be presented on June 21 in New York City , ... Provo, Utah (Vocus) May 20, 2010 -- Tahitian Noni ... , , , ,The American Business Awards is the nation’s premier business awards program. All ...
Cached Medicine News:Health News:Rotary International and I Imagine Studio Have Teamed up to Helps Kick Polio out of Africa 2Health News:Rotary International and I Imagine Studio Have Teamed up to Helps Kick Polio out of Africa 3Health News:Citizen Stock Launches Industry's First Rights Managed Database of Images Shot Exclusively Against White 2Health News:IT-Lifeline, Inc and OptiStor Technologies, Inc. Enter Joint Marketing Agreement 2Health News:IT-Lifeline, Inc and OptiStor Technologies, Inc. Enter Joint Marketing Agreement 3Health News:Post-Chemo Treatment May Boost Lung Cancer Survival 2Health News:More Steps a Day Lead to Better Health 2Health News:More Steps a Day Lead to Better Health 3Health News:Tahitian Noni International Named As Finalist In 2010 American Business Awards 2
(Date:8/31/2015)... 2015  Chiasma, Inc. (NASDAQ: CHMA ), ... for the orphan condition acromegaly, today reported financial ... 2015 and provided a corporate update. ... time for Chiasma, as we successfully completed our ... first New Drug Application (NDA) has been accepted ...
(Date:8/31/2015)... 2015 With increasing clinical applications, the ... rise in active partnerships. The primary reason for ... quantitate CD4 cell markers in human immunodeficiency virus ... New analysis from Frost ... Market ( http://www.frost.com/nf0e ), finds the market earned ...
(Date:8/31/2015)... Aug. 31, 2015  The departments of Drug and ... at Gaudenzia Concept 90 to raise awareness for International ... in Pennsylvania and help more ... on recovery through the Building Bridges to Recovery ... dying every day to a disease that is fully ...
Breaking Medicine Technology:Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 2Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 3Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 4Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 5Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 6Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 7Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 8Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 9Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 2Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 3Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 4Pennsylvania Departments of Drug & Alcohol Programs and Health Kick-off Second Annual Building Bridges to Recovery Initiative 2
... Identify Unique microRNA Signatures That Will ... Project Will Leverage Rosetta Genomics, Proprietary microRNA Extraction, and Quantification Technologies, ... and Experience ... Patients With High Risk, of Recurrence, who may Benefit From Adjuvant ...
... Accrual and Expansion Plans for SB-509-701 Phase 2 Clinical Trial for ... ... Neuropathy, SAN FRANCISCO, June 6 Sangamo BioSciences,Inc. (Nasdaq: SGMO ... trial (SB-509-701) in subjects with moderate to,severe diabetic neuropathy. Additionally, based upon ...
Cached Medicine Technology:Rosetta Genomics and M. D. Anderson to Develop a MicroRNA-based Diagnostic Test to Identify Risk of Recurrence of Lung Cancer 2Rosetta Genomics and M. D. Anderson to Develop a MicroRNA-based Diagnostic Test to Identify Risk of Recurrence of Lung Cancer 3Rosetta Genomics and M. D. Anderson to Develop a MicroRNA-based Diagnostic Test to Identify Risk of Recurrence of Lung Cancer 4Rosetta Genomics and M. D. Anderson to Develop a MicroRNA-based Diagnostic Test to Identify Risk of Recurrence of Lung Cancer 5Sangamo BioSciences Provides Update on Diabetic Neuropathy Clinical Programs 2Sangamo BioSciences Provides Update on Diabetic Neuropathy Clinical Programs 3Sangamo BioSciences Provides Update on Diabetic Neuropathy Clinical Programs 4Sangamo BioSciences Provides Update on Diabetic Neuropathy Clinical Programs 5
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: