Navigation Links
3D mapping biopsy finds 3x prostate cancer of ultrasound-guided biopsy
Date:2/4/2014

Ultrasound-guided biopsies miss prostate cancers that are detected by the slightly more expensive and slightly more invasive 3D mapping biopsies. For example, in a 2006 study of 180 men diagnosed with early stage prostate cancer via ultrasound-guided biopsy, nearly a quarter were upgraded to a more clinically significant stage of disease after 3D mapping biopsy found pockets of cancer the first technique had missed. Now, a University of Colorado Cancer Center study reports the locations of these most-missed pockets of prostate cancer.

"There are three major reason we perform these 3D mapping biopsies in the clinic: first, a man may have rising PSA despite a series of negative biopsies and so want a more detailed opinion; second, a man may prefer additional reassurance that watching and waiting rather than treatment is the best course of action; and third, a man may pursue focal therapy in which only the cancerous sections of the prostate are removed and so need accurate information on the position of his cancer," says Al Barqawi, MD, investigator at the CU Cancer Center, associate professor at the CU School of Medicine, and the paper's senior author. Barqawi is a pioneer of the 3D mapping biopsy technique, in which needle biopsies are taken 5mm apart across the x, y and z axes of a three-dimensional grid through the prostate, and has performed over 600 of the procedures.

The current study enrolled 161 men with a mean age of 61.6 years, who had been diagnosed with low-stage prostate cancer by ultrasound-guided biopsy. The study performed 3D mapping biopsies at a mean 192 days after the first and compared the results. Overall, ultrasound-guided biopsy found an average of 1.38 cancerous zones per patient, whereas 3D mapping biopsy found nearly three times the number of positive zones, at 3.33 per patient.

The follow-up findings from the 3D mapping study resulted in upgrading the severity of many of these seemingly low-grade cancers. Specifically, after first biopsy, 7.5 percent of patients had been graded Gleason 7 the lowest grade at which treatment is considered "medium risk" and for which treatment is a reasonable option and after second biopsy the percentage increased to twenty-five. After first biopsy, no patients had been scored above Gleason 7, and after 3D mapping biopsy, 4 percent were found to have Gleason 8, and 2 percent had Gleason 9.

"But we already knew that 3D mapping was likely to upgrade a prostate cancer's Gleason score," Barqawi says. "What we hoped to discover in this study is exactly where cancer is being missed by ultrasound-guided biopsy."

Of these 161 total cases, cancer was found in the left-mid section of the prostate 62 times after it had been missed by ultrasound-guided biopsy. Likewise, 3D mapping found 62 unreported cancers in the right-mid section and 41 undetected cancers in the left-apex zone.

"This study adds to our knowledge about the interface and best uses of these two techniques. The cost and invasiveness of 3d mapping biopsy make it inappropriate for screening, but our message is that with the confirmation or strong suspicion of cancer, 3D mapping biopsy offers a much more accurate assessment of the location, stage and risk," Barqawi says.


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. Mapping the brain to understand cultural differences
2. TGen-TD2-Scottsdale Healthcare breast cancer pilot study shows value of proteomic mapping
3. A fundamental problem for brain mapping
4. Robotic ultrasound gives surgeon more direct control in mapping and removing kidney cancers
5. Surrey Doctor Uses Ultrasound Mapping to Identify and Clear Leg Veins
6. UT Arlington physicists tool has potential for brain mapping
7. First Complete Mapping of the Alzheimer’s Genome Underway
8. Non-invasive mapping helps to localize language centers before brain surgery
9. Obama Unveils Vast Brain-Mapping Project
10. Personalized brain mapping technique preserves function following brain tumor surgery
11. Researchers decode biology of blood and iron disorders mapping out novel future therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... February 05, 2016 , ... Freed-Hardeman University President Joe ... signed a joint enrollment and degree completion agreement. The agreement, which begins ... degrees at FHU|Dickson. , The agreement allows students to be jointly admitted ...
(Date:2/5/2016)... ... February 05, 2016 , ... In the fourth ... country gathered at the La Valencia Hotel in San Diego, California to discuss ... named the year’s most outstanding franchise, walking away with the coveted David Wright ...
(Date:2/5/2016)... SARASOTA, Fla., (PRWEB) , ... February 05, 2016 , ... ... appetizing recipes just in time for this weekend’s Big Game. Take the stress out ... ingredients that will keep your guests happy at every stage of the game. , ...
(Date:2/5/2016)... ... February 05, 2016 , ... Stuart Bentkover, MD, FACS is ... to provide the most effective tattoo removal today, Dr. Bentkover is the only doctor ... by Cynosure, the PicoSure has been approved by the Food and Drug Administration (FDA) ...
(Date:2/5/2016)... ... February 05, 2016 , ... Health and wellness is a topic that should ... event they are experiencing an illness. Migraines are a severe form of a headache ... migraines would not wish the pain on their worst enemy, the feeling can last ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Calif. , Feb. 4, 2016  Edwards Lifesciences ... patient-focused innovations for structural heart disease and critical care ... accelerated share repurchase (ASR) agreement with Morgan Stanley & ... stock.  This repurchase is part of the Company,s previously ... the Company,s common stock.  --> ...
(Date:2/4/2016)... Feb. 4, 2016 Worldwide Radiology Oncology ... growth as next generation systems provide a way ... for cancer surgery. New systems pinpoint the delivery ... has been such a problem previously, limiting the ... robots take cancer surgery far beyond what has ...
(Date:2/4/2016)... Calif. , Feb. 4, 2016  SciClone ... today announced it has entered into a settlement ... Commission (SEC) fully resolving the SEC,s investigation into ... (FCPA).  Under the terms of the settlement agreement, ... $12.8 million, including disgorgement, pre-judgment interest and a ...
Breaking Medicine Technology: