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3 studies confirm the value of etanercept therapy in treating juvenile idiopathic arthritis
Date:6/12/2009

atients of all subtypes who previously have not responded to other second-line drugs."

3. Delayed clinical response in patients with juvenile idiopathic arthritis treated with etanercept. (FRI0478)

From 179 JIA patients in the ABC-register, with a minimal follow-up of 15 months, the clinical response was assessed using the American College of Rheumatology Paediatric 30 variables. Of the 34 patients who initially failed to meet these response criteria, 21 continued etanercept therapy and 12 patients reached a delayed response at 15 months of treatment. Overall, 7% of the 179 patients were delayed responders after 3 months of treatment and this was most likely in those with the oligoarticular, arthritis psoriatica and enthesitis related arthritis subtypes.

Dr Marieke H. Otten of the Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands, said: 'Biological agents are one of the last therapeutic options for JIA and have shown to be highly effective in refractory patients. Previous studies on etanercept have shown rapid improvements, but the optimal duration to evaluate effectiveness is still unknown. This study shows a delayed clinical response in a substantial proportion of the patients treated with etanercept. We advise, especially in patients with a partial response, to continue treatment to at least six months.'


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Contact: Rory Berrie
eularpressoffice@uk.cohnwolfe.com
44-789-439-6425
European League Against Rheumatism
Source:Eurekalert

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