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3 studies confirm the value of etanercept therapy in treating juvenile idiopathic arthritis
Date:6/12/2009

nts with refractory juvenile idiopathic arthritis. (THU0426)

In 53 JIA patients, who previously did not respond to other second-line drugs, data were collected to evaluate HRQoL during treatment with etanercept. HRQoL was measured by the Childhood Health Assessment Questionnaire (CHAQ), Child Health Questionnaire (CHQ) and Health Utilities Index mark 3 (HUI3) before start and after 3, 15 and 27 months. At the same time-points, information on JIA disease activity variables were also collected, including; physician's global assessment through the Visual Analogue Scale (VAS), number of active and limited joints and erythrocyte sedimentation rate. Linear mixed models were used to assess outcomes over time.

Significant improvements in HRQoL were seen during the 27 month study period. The disease specific CHAQ, including the VAS pain and VAS well-being scores showed a significant improvement on all domains (p<0.001). The generic health-profile measure CHQ improved on all the health concepts (p<0.05) except 'family cohesion', which is known to be unaffected by JIA.1 The generic preference-based HUI3 showed significant improvement (p<0.05) on the more specific areas of 'pain', 'ambulatory', and 'dexterity'. In accordance, disease activity variables improved significantly over time (p<0.001).

Dr Femke H.M. Prince of the Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands, said: "JIA, the most common cause of chronic arthritis in children, frequently results in physical disabilities and chronic pain influencing daily life. The results for the Arthritis and Biologicals in Children project show impressive improvement on all domains of Health-Related Quality of Life impaired by JIA during treatment with etanercept. This indicates that these previously severely ill children, as well as their families, gain great benefits from this treatment. The results of our studies add to the bank of research on the role of etanercept in treating JIA p
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Contact: Rory Berrie
eularpressoffice@uk.cohnwolfe.com
44-789-439-6425
European League Against Rheumatism
Source:Eurekalert

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