Navigation Links
3 newly discovered ERK pathway proteins related to CagA induced disease

Cytotoxin-associated gene A protein (CagA) from type I H.pylori has been proved by epidemiological and experimental studies to be closely associated with the H.pylori induced gastric diseases, especially gastric cancer. However, the precise role of CagA in cell function after H. pylori infection remains unclear and no study on exploring the global protein expression pattern which can reflect host cells response to CagA has been reported.

A research article to be published on January 28, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Zheng from Cancer Institute of Zhejiang University used ProteinChip platform, which is based on surface enhanced laser desorption / ionization time-of-flight mass spectrometry (SELDI-TOF-MS) technology, to study the global protein expression changes in AGS cells transfected with CagA gene. As various researches indicated a relationship among CagA, ERK/MAPK pathway activation and gastric cancer, the article further investigate the relationship of these protein expression differences and activation of ERK pathway by adding specific mitogen-activated protein kinase kinase (MEK) inhibitor during transfection.

When 16 proteins showed expression differences after CagA transfection, three proteins with molecular weights of 4 229, 8 162 and 9 084 Dalton were found have no expression differences under the treatment of MEK inhibitor, indicating they are downstream molecules of ERK1/2 in ERK/MAPK signaling pathway. Matching information from Swiss-Prot/TrEMBL database indicates these three proteins may be related with cell apoptosis, cell antimicrobial defense, chemotactic function, cell proliferation, differentiation and carcinogenesis, and therefore have great potential to be identified as cancer-associated proteins in further research.

Due to the high sensitivity and resolution in low molecular weight range of SELDI-ProteinChip technology, biomarkers discovered in this study are mainly low mass range and/or low abundance disease related proteins, which are difficult to detect by traditional methods. These results demonstrate a new view of molecules involved in the CagA related signaling pathways, and thus may provide new targets for further understanding of the biological function of CagA and new therapeutic targets.


Contact: Jing Zhu
World Journal of Gastroenterology

Related medicine news :

1. Gene newly linked to inherited ALS may also play role in common dementia
2. Newly discovered role of thyroid hormone during pregnancy
3. Newly Released 2009 COLA Forecast Would Keep Five Million Seniors Below Poverty Line
4. Anxiety linked to newly diagnosed DCIS patients overestimation of breast cancer risks
5. Newly Published Study Demonstrates Return on Investment for Employee Wellness Program
6. Newly discovered virus linked to deadly skin cancer
7. Antibody Engineering Company f-star Appoints Three Pioneers in Antibody Engineering and Development to its Newly Established Scientific Advisory Board
8. New therapeutic options for newly diagnosed multiple myeloma patients
9. Thalidomide Added to Standard Therapy Prolongs Overall Survival in Newly Diagnosed Multiple Myeloma Patients Over Age 75
10. Newly HIV-Infected Gay Men Select Other Infected Partners
11. Striking shift seen among newly HIV-infected men regarding partners
Post Your Comments:
(Date:12/1/2015)... ... December 01, 2015 , ... ... optimization of adjunctive imaging is the focus of numerous abstracts accepted for presentation ... 29-December 4, 2015. Nine abstracts highlight the use of Volpara Solutions’ quantitative ...
(Date:12/1/2015)... ... December 01, 2015 , ... SAN FRANCISCO, Calif. (December ... the organization has awarded Education and Developmental Therapies (EDT), an Applied Behavior Analysis ... celebrates exceptional special needs providers that excel in synthesizing the areas of clinical ...
(Date:12/1/2015)... ... December 01, 2015 , ... TCS Healthcare Technologies (TCS), a ... health arenas, is pleased to announce that VIP Care Services, a Caprock Health ... the ACUITY Complete Care™ Management to back their collaborative catastrophic case management initiatives. ...
(Date:12/1/2015)... ... December 01, 2015 , ... With FCPX Overlay: Grit , users ... over customization, the possibilities are truly endless, all with a click of a mouse. ... vertical flip, horizontal flip, depth of field and more, all within Final Cut Pro ...
(Date:12/1/2015)... ... December 01, 2015 , ... Tympani Inc., announced today ... status from Cisco. This designation recognizes Tympani as having fulfilled the training requirements ... targeted to the high-end enterprise contact center marketplace. , Ed Kapelinski, President of ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... Colo. , Dec. 1, 2015 /PRNewswire/ ... ) today announced that its Chief Executive ... at the Oppenheimer Annual Healthcare Conference in ... participate in the conference through a webcast ... , --> ...
(Date:12/1/2015)... , Dec. 1, 2015 Pharma Tech ... Top 10 Clinical Data Management Solution Providers - ... a distinguished panel comprising CEOs, CIOs, VCs, analysts, and ... the illustrious list of top 10 clinical data management ... article on pages 14 and 36 respectively). ...
(Date:12/1/2015)... de diciembre de 2015  AccuTEC Blades, ... de precisión, develó hoy un nuevo logo ... marca. El nuevo logo destaca la experiencia ... ingeniería de productos con cuchillas donde "el ... --> ...
Breaking Medicine Technology: