Navigation Links
3-drug combination 'extremely promising' as first-line therapy for multiple myeloma
Date:12/11/2007

ATLANTAA new combination of bortezomib (Velcade) and two other drugs is showing a very high response rate in patients newly diagnosed with multiple myeloma, a team headed by Dana-Farber Cancer Institute investigators reported at the annual meeting of the American Society of Hematology.

The three-pronged regimen of Velcade, lenalidomide (Revlimid) and dexamethasone referred to as Rev/Vel/Dex has achieved an overall response rate of 98 percent in 42 patients evaluated thus far in a Phase 1-2 trial, said Paul Richardson, MD, of Dana-Farber and the studys principal investigator. He added that 52 percent of the patients had high quality responses (very good partial response or better), with 30 percent achieving complete response to date.

These may be some of the best response rates weve seen to date with up-front therapies, and although these are preliminary results, they are extremely promising, Richardson said. The patients were previously untreated when they received the Rev/Vel/Dex combination.

Velcade is a smart drug known as a proteasome inhibitor that blocks the myeloma cells waste disposal system, creating an accumulation of toxic compounds that poison the cell. Revlimid is a chemical relative of thalidomide that affects several pathways in cancer cells, including immune mechanisms and blood vessel growth to tumors. Dexamethasone is a steroid hormone that counters inflammation and is used to treat hematologic malignancies such as myeloma. Studies leading to the trial of the three drugs in combination were carried out at Dana-Farber.

While these are the first results from trials of Rev/Vel/Dex given as initial, first-line therapy for the blood cancer, the combination has already been shown effective for multiple myeloma patients who had relapsed following successful treatment or who had not responded to standard therapies.

Richardson also reported at the ASH meeting preliminary data from a Dana-Farber led mul
'/>"/>

Contact: Teresa Herbert
617-632-4090
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Promising drug combination may help those with ocular melanoma that has spread
2. Combination therapy reverses effects of portal hypertension in rats
3. Combination vaccines okay for infants, study shows
4. Antidepressants and painkillers - a dangerous combination
5. Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma
6. U.S. Oncology Initiates Complete Phase Ib Trial of Brostallicin Combination Therapy in Advanced Solid Tumors
7. Drug combination might offer hope for patients deadly brain tumors
8. EpiCept to Present Preclinical Studies of EPC2407 in Combination With Anti-Angiogenic and Chemotherpeutic Agents at the AACR-NCI-EORTC International Conference
9. Combination targets: some drugs may work best when they work together
10. MAP Pharmaceuticals Initiates Phase 2a Clinical Trial of Combination Therapy in Adult Patients with Asthma
11. Quality Control: Nissan Quest to Feature micronAir(R) Combination Cabin Air Filters
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2008)...r-old Contestant Wins Trip to Little League Baseba... The National Spit Tobacco Education,Program (NSTE...st today,and encouraged young baseball players to...ddiction and the health risks of using tobacco pro...year,s slogan contest winner is,Joe Reck, a nine-y...
(Date:8/20/2008)...cently enacted Medicare Improvement Law immediatel...re Advantage insurance companies .../PRNewswire/ -- When the House and Senate,overrode...gislation,protecting Medicare beneficiaries, they ...e Advantage plans during one of the busiest months...
(Date:8/20/2008)...T CREEK, Calif., Aug. 20 /PRNewswire-FirstCall/ --... reported preliminary income from,continuing opera...f $27.5,million, or $0.76 per diluted share, inclu...er diluted share, related to provisions for store,... a 6.8 percent increase,compared with income from ...
(Date:8/20/2008)...FIELD, Mich., Aug. 20 /PRNewswire/ -- WXYZ- TV/Cha...llness Promotion will give thousands of,Detroit me...ALTHY LIVING,FOR KIDS" program. This year the prog....m. to 5 p.m. at the Charles H. Wright Museum of A...77, "Healthy Living for Kids",has provided free im...
Breaking Medicine News(10 mins):Health News:Slogan Contest Educates Young Baseball Players About the Dangers of Tobacco Use 2Health News:Medicare Advantage Plans Struggle to Comply With New Federal Law 2Health News:Longs Drug Stores Corporation Reports Second Quarter Results 2Health News:Longs Drug Stores Corporation Reports Second Quarter Results 3Health News:Longs Drug Stores Corporation Reports Second Quarter Results 4Health News:Longs Drug Stores Corporation Reports Second Quarter Results 5Health News:Longs Drug Stores Corporation Reports Second Quarter Results 6Health News:Longs Drug Stores Corporation Reports Second Quarter Results 7Health News:Longs Drug Stores Corporation Reports Second Quarter Results 8Health News:Longs Drug Stores Corporation Reports Second Quarter Results 9Health News:Longs Drug Stores Corporation Reports Second Quarter Results 10Health News:Longs Drug Stores Corporation Reports Second Quarter Results 11Health News:Longs Drug Stores Corporation Reports Second Quarter Results 12Health News:Longs Drug Stores Corporation Reports Second Quarter Results 13Health News:WXYZ-TV/Channel 7 is 'On Your Side' With Healthy Living For Kids; Free Immunizations for Children on Sunday, August 24 at Charles H. Wright Museum of African American History 2Health News:WXYZ-TV/Channel 7 is 'On Your Side' With Healthy Living For Kids; Free Immunizations for Children on Sunday, August 24 at Charles H. Wright Museum of African American History 3
...Indians are being hit the most by obesity-related ...agnosis done by doctors that fails to// detect the...sure of weight divided by height- is used in the s...er, according to the experts, East and South Asian...
...ough, towards the testing and cure for the pregnan... the US National Institutes of Health team found w...teins several months before developing the conditi...ained that the two proteins secreted by the placen...
...of death in Canada ahead of HIV/AIDS, diabetes and...hin Aboriginal communities. With World// Suicide P...wo experts from the Canadian Institutes of Health ...ealth challenges posed by suicide, its causes and ...
...and the Barcelona soccer club announced a plan on ...9 million a year over the next five// years to hel...ping countries. Their first installment will go t... a poverty stricken country in southern Africa whe...
Other Medicine News:Health News:Placental Proteins Could Be Responsible For Pre-eclampsia 2Health News:Getting Serious About Suicide Prevention 2
(Date:8/19/2008)... BETHLEHEM, Pa., Aug. 19 /- Particl...ct (drug-eluting polymers) development and,pilot p...compounding,extrusion and injection molding line....in-screw compounding extruder and Nissei 20T injec...y drug loaded polymeric,devices. This addition giv...
(Date:8/18/2008)... NORRISTOWN, Pa., Aug. 18 /PRNewswire-USNewswire...ile virus-infected mosquitoes in,southeastern Penn...on and,its county partners will be stepping up eff...that have -- or are most likely to carry -- the vi...virus has been confirmed,this year (a 27-year-old ...
(Date:8/18/2008)... Initiates Clinical Trials Phase of Test Dev.../- Beckman,Coulter, Inc. (N...ement to,buy out its U.S. royalty obligation to Ne... focused on women,s health. The license is for tes...ssessment of preeclampsia, a,leading cause of mate...
(Date:8/15/2008)... AUDUBON, Pa., Aug. 15 /- Globus Me...lant manufacturer in the world, today announced,th...been implanted under an,Investigational Device Exe...onald Johnson II and Dr. Rhett Murray., The FLEXU...between two,spinous processes with minimal disrupt...
Breaking Medicine Technology:Particle Sciences Expands Its Combination Product Capabilities 2Positive Mosquito Count for West Nile Virus Lead DEP, Southeastern PA Counties to Ramp up Treatment Activities 2Positive Mosquito Count for West Nile Virus Lead DEP, Southeastern PA Counties to Ramp up Treatment Activities 3Beckman Coulter Buys Out Royalty Obligation for Preeclampsia Markers 2Beckman Coulter Buys Out Royalty Obligation for Preeclampsia Markers 3First FLEXUS(TM) Interspinous Spacer Surgeries for IDE Clinical Trial 2Most Asthmatics Dont Have Illness Under Control 4594 1Most Asthmatics Dont Have Illness Under Control 4594 2Most Asthmatics Dont Have Illness Under Control 4594 3HIV patients sicker when seeking care than in the past 4592 1HIV patients sicker when seeking care than in the past 4592 2Research sheds new light on how diseases jump across species 968 1Research sheds new light on how diseases jump across species 968 2Knocking out cell receptor may help block fat deposits in tissues prevent weight gain 966 1Knocking out cell receptor may help block fat deposits in tissues prevent weight gain 966 2
Anti-Skin Antibody (ASA) Test Kit: Pemphigus and Bullous Pemphigoid
...leading provider of immunofluorescence assays, wit... kits for autoimmune diseases, infectious diseases...components. Our Impact IFA Test Systems give you a...oose from. Kit components include substrate slides...
With advanced glass technologies and designs, the Digital ClearMag lens delivers enhanced high magnification views of the posterior pole. Using this advanced lens will provide image quality previousl
...e single-well ANA screen and ENA screen ELISAs, as...d 6 individual ENA kits: Sm, Sm/RNP, SS-A (Ro), SS...une ELISA family includes a full line of products ...hyroid Microsomal, MPO, PR3, Rheumatoid Factor and...
Medicine Products: