3 brain diseases linked by toxic form of same neur... (initiate regionalized cell death. This w...)

3 brain diseases linked by toxic form of same neural protein

Date:2/2/2010

initiate regionalized cell death. This was accomplished through site-directed mutations and insertion of the mutated Elk-1 mRNA into dendrites and cell bodies. These studies showed that a specific position on the protein could be modified in the dendrite to cause neuronal cell death.

Next, they screened tissue from a post-mortem human brain bank, specifically samples representative of the three major neurodegenerative diseases, to look for higher levels of the toxic form of Elk-1 protein and compared their findings to levels in brain tissue from age-matched control samples.

By comparing the immunoreactivity for the pElk-1 protein in diseased tissue versus control tissue, they found that pElk-1 strongly associates with the pathological markers present in cases of Parkinson's disease, Alzheimer's disease, and Huntington's disease versus disease-free tissue.

The team hopes to next expand these preliminary findings to a larger sample size of tissues from neurodegenerative disease banks, and to screen blood samples from affected individuals to assess the biomarker capacity of this form of Elk-1 and to use animal models of these illnesses to assess the biological role of this modified form of Elk-1 in the disease processes. They also will be looking for other sites of toxic changes on the Elk-1 protein and will look in other disease tissue for modified Elk-1.

'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

0

GOOD

Page: 1 2
Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Vision restoration therapy shown to improve brain activity in brain injured patients
3. Clinical depression linked to abnormal emotional brain circuits
4. Brain imaging reveals breakdown of normal emotional processing
5. Brain cells work differently than previously thought
6. Vaccine Stops Alzheimers Brain Tangles
7. Research may unlock mystery of autisms origin in the brain
8. Scientists Spot Brains Free Will Center
9. Free will takes flight: how our brains respond to an approaching menace
10. Alcoholics With Cirrhosis Have More Brain Damage
11. Brain Lesions Predict MS Progression

Post Your Comments:

Related Image:

3 brain diseases linked by toxic form of same neural protein

(Date:5/20/2013)... (PRWEB) May 20, 2013 iGearUnlimited.com asked schools' ... iPad case for students. The answers didn't surprise anyone: , ... daily use and abuse, 2. Not too bulky – need ... backpack, 3. Built-in kick-stand that works in both vertical and ... as a trackable barcodes on each case, 5. Customizable – ...

(Date:5/20/2013)... Atlanta, GA (PRWEB) May 20, 2013 ... opening of their newest office on Briarcliff Road in ... urgent care facility includes Dr. Fidias E. De ... massage therapists who will provide extensive medical services, occupational ... of the greater Atlanta metropolitan area. They also offer ...

(Date:5/20/2013)... OH (PRWEB) May 20, 2013 The ... experienced medical device law firm, report that two important ... coming months in state and federal litigations established for ... June 11th, the first C.R. Bard bellwether trial will ... Southern District of West Virginia. (In re: C.R. ...

(Date:5/19/2013)... NY (PRWEB) May 20, 2013 Alonso ... they are representing a New York woman in a ... with the National Football League (NFL). According to an ... Petitioner is seeking a declaration of paternity, order of support ... of her son with Mr. Walker. (Docket No. P-18821-13) ...

(Date:5/19/2013)... measure of the heterogeneity the variety of genetic mutations ... outcomes of patients with the most common type of head ... the journal Cancer , investigators at Massachusetts General Hospital ... measure was a better predictor of survival than most traditional ... cell carcinoma of the head and neck. , ...

Breaking Medicine News(10 mins):Health News:New Rugged iPad Case for Bretford Charging Cart Saves the Day for School Deployments 2 Health News:New Rugged iPad Case for Bretford Charging Cart Saves the Day for School Deployments 3 Health News:Healing Heart Urgent Care Opens New Office In Atlanta 2 Health News:Transvaginal Mesh Lawyers at Wright & Schulte LLC Look Ahead to Upcoming Vaginal Mesh Lawsuit Bellwether Trials 2 Health News:Transvaginal Mesh Lawyers at Wright & Schulte LLC Look Ahead to Upcoming Vaginal Mesh Lawsuit Bellwether Trials 3 Health News:Transvaginal Mesh Lawyers at Wright & Schulte LLC Look Ahead to Upcoming Vaginal Mesh Lawsuit Bellwether Trials 4 Health News:New York Woman in Paternity Petition Against Former NFL Running Back, Herschel Walker, Alonso Krangle LLP Representing Petitioner 2 Health News:New York Woman in Paternity Petition Against Former NFL Running Back, Herschel Walker, Alonso Krangle LLP Representing Petitioner 3 Health News:Genetic diversity within tumors predicts outcome in head and neck cancer 2 Health News:Genetic diversity within tumors predicts outcome in head and neck cancer 3

[0] New Rugged iPad Case for Bretford Charging Cart Saves the Day for School Deployments [0] Healing Heart Urgent Care Opens New Office In Atlanta [0] Transvaginal Mesh Lawyers at Wright & Schulte LLC Look Ahead to Upcoming Vaginal Mesh Lawsuit Bellwether Trials [0] New York Woman in Paternity Petition Against Former NFL Running Back, Herschel Walker, Alonso Krangle LLP Representing Petitioner [0] Genetic diversity within tumors predicts outcome in head and neck cancer

... 91% Increase in Earnings for First Half of 2008 ... Metropolitan,Health Networks, Inc. (Amex: MDF ), a ... results for the six months,and quarter ended June 30, ... that in the three months ended,June 30, 2008, the ...

... /Xinhua-PRNewswire/ -- Simcere Pharmaceutical,Group (NYSE: SCR ), a ... of the patented anti-cancer biotech,product Endu in China, today ... 2008., Highlights -- Total revenue increased ... second quarter, representing a 30.4% year-over-year growth;, ...

... Year-over-Year to $10.7 Million Backlog Reaches $72 ... Million ... to Market Recently-introduced Odyssey System Building Strong Market Momentum, ST. ... second quarter ended June,30, 2008. Revenue for the recent second quarter increased 36% ...

... goes for gold and aims to give back to Mercy Ships ... ... Laser Champion and one of Britain,s greatest medal hopes at the Beijing ... charity Mercy Ships which provides free medical care to the people of ...

... major website re-design, aimed specifically toward potential clients, with improved ... ... New York, NY (PRWEB) August 5, 2008 -- ... re-design, aimed specifically toward potential clients, with improved navigability, clear ...

... esignature, Princor representatives now benefit from a more efficient account ... ... Ontario, CA (PRWEB) August 5, 2008 -- Interlink Electronics, Inc. ... Corporation, a member of the Principal Financial Group®. The Princor® ...

Metropolitan Health Networks Reports 2008 Second Quarter Results Simcere Pharmaceutical Group Reports Unaudited Second Quarter 2008 Results Stereotaxis Reports Record Second Quarter Revenue Olympic Sailing Hopeful Backs Hospital Ship Charity Re-Designed Legal Website Includes Blog Interlink and LaserApp Partnership Provides eSignature-Ready Forms to Princor Financial Services

(Date:5/18/2013)... 2013 The Open Paradigm Project, in ... Occupy Psychiatry , and leading organizations in the ... social media campaign showcasing video testimonials by individuals ... focuses on pathology and illness rather than wellness ... Psychiatric Association,s (APA) rollout of its latest revision ...

(Date:5/17/2013)... -- Medical devices are any medical items that are ... of their different mechanisms, actions and regulatory requirements, medical ... drug trails due to their unique clinical practices. Currently, ... both safety and efficacy (which is left to the ... as the SFDA) evaluate MDs for both safety and ...

(Date:5/17/2013)... , May 17, 2013 Orexigen® Therapeutics, Inc. (Nasdaq: ... a company overview at the UBS Global Healthcare Conference in ... for Wednesday, May 22 nd at 11 a.m. Eastern ... of the presentation, please visit the Investor Relations section of ... will be available for 14 days after the event. ...

Breaking Medicine Technology:New Social Media Campaign Features Stories Of Individuals Who Rejected Psychiatric Diagnoses 2 New Social Media Campaign Features Stories Of Individuals Who Rejected Psychiatric Diagnoses 3 Statistical Challenges in Medical Device Trail Evaluation 2

[0] New Social Media Campaign Features Stories Of Individuals Who Rejected Psychiatric Diagnoses [0] Statistical Challenges in Medical Device Trail Evaluation [0] Orexigen Therapeutics to Present at the UBS Global Healthcare Conference

... ADD NEW CENTERS AND TO ... INCREASE AWARENESS AMONG CARDIOLOGISTS, PLEASANTON, Calif., April 21 ... device-based mechanical,circulatory support therapies to save, support and restore failing ... PMA (PreMarket,Approval) application, allowing the use of its HeartMate II ...

... EDISON, N.J., April 21 Nostrum, a ... today that it has,successfully completed its early, ... protein currently known as SMRX11. Nostrum,s,Symmetrix subsidiary, ... drug under Nostrum,s license from the Institute ...

Cached Medicine Technology:Thoratec Announces FDA Approval of HeartMate II(R) for Bridge-To-Transplantation 2 Thoratec Announces FDA Approval of HeartMate II(R) for Bridge-To-Transplantation 3 Thoratec Announces FDA Approval of HeartMate II(R) for Bridge-To-Transplantation 4 Thoratec Announces FDA Approval of HeartMate II(R) for Bridge-To-Transplantation 5 Nostrum Announces the Successful Completion of Early Proof-of-Concept Study for its Novel Clot Busting Therapeutic Protein 2

Thoratec Announces FDA Approval of HeartMate II(R) for Bridge-To-Transplantation Nostrum Announces the Successful Completion of Early Proof-of-Concept Study for its Novel Clot Busting Therapeutic Protein

The Easy Wrap Apron is now available with an attached Thyroid Collar. The Thyroid Collar is held on with velcro so it adjusts to fully protect the neck. This Apron with Collar is available in 5mm lea...

... system is a long term, ... clinically proven design. Available in ... correct cruciate retaining configurations. In ... of identification keeps the user ...

... The Genesis II® Total Knee System ... Now, far more is possible with less ... options, while fully addressing both clinical and ... meet these design goals, giving surgeons creative ...

Cementless hip system...

Medicine Products:

Easy Wrap Apron w/Collar: Lead Free Proven™ Posterior Stabilized Knee System Genesis II® Total Knee System Primaloc™ Cementless