Navigation Links
3 brain diseases linked by toxic form of same neural protein
Date:2/2/2010

PHILADELPHIA - For the first time, researchers from the University of Pennsylvania School of Medicine have found that three different degenerative brain disorders are linked by a toxic form of the same protein. The protein, called Elk-1, was found in clumps of misshaped proteins that are the hallmarks of Parkinson's disease, Alzheimer's disease, and Huntington's disease.

"These results suggest a molecular link between the presence of inclusions and neuronal loss that is shared across a spectrum of neurodegenerative disease," notes senior author, James Eberwine, PhD, co-director of the Penn Genome Frontiers Institute and the Elmer Holmes Bobst Professor of Pharmacology. "Identifying these links within the diseased microenvironment will open up novel avenues for therapeutic intervention. For example it is reasonable to now ask "Is this molecule a possible new biomarker for these neurodegenerative diseases?" says Eberwine.

Eberwine, co-first authors Anup Sharma, an MD-PhD student, Jai-Yoon Sul, PhD, Assistant Professor of Pharmacology, both from Penn, Linda M. Callahan, PhD, from the University of Rochester Medical Center, and colleagues, report their findings this week in the online journal PLoS One.

Neurodegenerative diseases are characterized by a number of features including the protein clumps called inclusions; decline of nerve-cell synapses; and the selective loss of the nerve cells themselves.

Elk-1 resides within multiple brain areas, both in the nucleus and the cell body. Interestingly, when it is present in extensions of nerve cells called dendrites, it can initiate the death of that neuron. With this in mind the team assessed whether there is a specific dendrite form of Elk-1 or a modified form called phospho-Elk-1 (pElk-1) that might be associated with a spectrum of human neurodegenerative diseases.

First, they determined the importance of this specific modification of Elk-1 on its ability to
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Vision restoration therapy shown to improve brain activity in brain injured patients
3. Clinical depression linked to abnormal emotional brain circuits
4. Brain imaging reveals breakdown of normal emotional processing
5. Brain cells work differently than previously thought
6. Vaccine Stops Alzheimers Brain Tangles
7. Research may unlock mystery of autisms origin in the brain
8. Scientists Spot Brains Free Will Center
9. Free will takes flight: how our brains respond to an approaching menace
10. Alcoholics With Cirrhosis Have More Brain Damage
11. Brain Lesions Predict MS Progression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
3 brain diseases linked by toxic form of same neural protein
(Date:11/27/2014)... News) -- Thanksgiving meals can pose a challenge for ... expert says. Many traditional Thanksgiving dishes -- such ... are gluten-free, but "when it comes to pies, stuffing, ... Dr. Anca Safta, director of the Gluten and Allergic ... in North Carolina, said in a center news release. ...
(Date:11/27/2014)... November 27, 2014 The founders of VIM ... comfortable and high functioning compression socks, are proud to announce ... use an innovative Gradient Pressure (TM) knitting technology that is ... VIM & VIGR’s commitment to adding flair and style to ... functional recently caught the eye of a writer at ...
(Date:11/27/2014)... NV (PRWEB) November 27, 2014 Now ... shopping season has officially launched, Emassagechair.com has ... Cyber Monday Discount Event. , Negotiating on behalf ... with top massage chair brands, Emassagechair.com has generated significant ... best deals and biggest discounts yet. , Shoppers are ...
(Date:11/27/2014)... Two international trainers and lecturers on the ... one person with significant needs but limited means obtain ... Mamaly Reshad of the Anacapa Dental Art Institute in ... devoted to helping dentist learn about using All-on-4™ dental ... devoted to helping a patient who has damaged or ...
(Date:11/27/2014)... DC (PRWEB) November 27, 2014 “Wekho” was ... features the latest and coolest mobile applications on the iOS, ... and host of NewsWatch, conducted the app review ... locations instead of people. , An interesting new way to ... iOS and Android devices. It’s called Wekho and it’s ...
Breaking Medicine News(10 mins):Health News:Expert Shares Gluten-Free Thanksgiving Tips 2Health News:VIM & VIGR Announces Launch of Men’s Line of Compression Socks 2Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 2Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 3Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 4Health News:World-Renowned Oxnard All-on-4™ Dental Implants Experts to Give Away Full Mouth Rehabilitation Annually 2Health News:World-Renowned Oxnard All-on-4™ Dental Implants Experts to Give Away Full Mouth Rehabilitation Annually 3Health News:World-Renowned Oxnard All-on-4™ Dental Implants Experts to Give Away Full Mouth Rehabilitation Annually 4Health News:World-Renowned Oxnard All-on-4™ Dental Implants Experts to Give Away Full Mouth Rehabilitation Annually 5Health News:A New Geolocation Mobile Application and was Featured on NewsWatch Television on October 30, 2014 2
... Steven Reinberg HealthDay Reporter , TUESDAY, Aug. 31 ... vegetables and low in saturated fats can significantly lower ... blood pressure, Johns Hopkins University researchers say. The ... to Stop Hypertension) -- was designed to lower blood pressure ...
... leading cause of cancer deaths worldwide, and the prognosis ... the incidence of one type of lung cancer, adenocarcinoma, ... of the changes in tumor cell biology that result ... abnormal mass of tissue) that have been completely surgically ...
... eight hours of sleep per night have greater risks of ... anxious symptoms, according to a study in the Sept. 1 ... average self-reported nightly sleep duration of eight to nine hours ... sleep durations of less than eight hours and psychological distress ...
... can expedite the communication of urgent findings and improve ... issue of the Journal of the American College ... practice in the United States is moving toward 24/7 ... such as computed tomography (CT) and magnetic resonance imaging ...
... the importance for women with a family history of breast or ... and BRCA2 genes that make them more likely to develop lethal ... The study, which will be published in the Sept. 1 issue ... shows women with the gene live longer and nearly eliminate their ...
... By Amanda Gardner HealthDay Reporter , TUESDAY, Aug. ... has issued a strong policy statement directed toward pediatricians, parents ... and children are getting about sex from television, the Internet ... and the Media , was published online Aug. 30 and ...
Cached Medicine News:Health News:'DASH Diet' Shown to Lower Heart Attack Risk Almost 20% 2Health News:'DASH Diet' Shown to Lower Heart Attack Risk Almost 20% 3Health News:Tumor budding identified as predictor for unfavorable outcome in lung cancer 2Health News:Study links shorter sleep durations with greater risks of mental distress in young adults 2Health News:Study links shorter sleep durations with greater risks of mental distress in young adults 3Health News:Staggered radiologist work shifts improve patient care, study suggests 2Health News:Preventive cancer surgeries save women's lives 2Health News:U.S. Pediatricians Decry Media's Portrayal of Sex 2Health News:U.S. Pediatricians Decry Media's Portrayal of Sex 3
(Date:11/26/2014)... 26, 2014  Avanir Pharmaceuticals, Inc. (NASDAQ: ... and Drug Administration (FDA) has issued a Complete ... for AVP-825. AVP-825 is an investigational drug-device combination ... utilizing a novel Breath Powered delivery technology. ... consistent with the preliminary feedback announced on November ...
(Date:11/26/2014)... -- Investor-Edge has initiated coverage on the following ... PLC (NASDAQ: HZNP ), Endocyte Inc. (NASDAQ: ... ), and Theravance Inc. (NASDAQ: THRX ). Free ... http://investor-edge.com/register . On Tuesday, November 25, 2014, the ... Industrial Average edged 0.02% lower, to finish the day at ...
(Date:11/26/2014)... , Inc. (NASDAQ: BIOS ) announced today that ... at the Bank of America Merrill Lynch 2014 Leveraged Finance Conference ... , Wednesday, December 3, 2014 , , , , Time: ... Location: , , , Boca Raton Resort and Club, Florida , ... BioScrip, Inc. is a leading national provider of infusion and ...
Breaking Medicine Technology:Avanir Pharmaceuticals Receives Complete Response Letter (CRL) from FDA on AVP-825 NDA 2Avanir Pharmaceuticals Receives Complete Response Letter (CRL) from FDA on AVP-825 NDA 3Avanir Pharmaceuticals Receives Complete Response Letter (CRL) from FDA on AVP-825 NDA 4Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 2Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 4Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 5
... 2012   SAP America Inc., a subsidiary ... SAP ), today introduced the SAP® Collaborative E-Care ... several modules, the application aims to connect care providers, patients ... was made at HIMSS 2012 , being held February ...
... Feb. 21, 2012 SurgLine International, Inc. (SGLN.PK). ... ("SurgLine") stated, "Over the past six months we have ... business arrangements, distribution contracts and a pending acquisition in ... continued progress. Our management team has ...
Cached Medicine Technology:Newsbyte: SAP to Integrate Healthcare in the Community Through Collaborative Care 2SurgLine International, Inc. Update to Shareholders on Revenue Pipeline and Organizational Changes 2
... The AtheNA Multi-Lyte Test System* is ... to simultaneously perform multiple assays from ... well. It offers a simple and ... testing, providing improved clinical sensitivity and ...
... precision, ergonomics, and value!, Comfortable ... soft non-slip, contoured handle , Finer ... plunger spring action , Completely autoclavable ... the need for recalibration , Easy-to-read ...
... For loading gel sample slots 0.4 mm ... Uses disposable, flexible, autoclavable, precision tapered polycarbonate ... does not contact sample. Includes 6 ... and one plastic spacer. ...
The Pipetman Large-Volume Kit includes two large-volume pipettes conveniently packaged with filters and tips at an exceptional price....
Medicine Products: