Navigation Links
3 brain diseases linked by toxic form of same neural protein
Date:2/2/2010

PHILADELPHIA - For the first time, researchers from the University of Pennsylvania School of Medicine have found that three different degenerative brain disorders are linked by a toxic form of the same protein. The protein, called Elk-1, was found in clumps of misshaped proteins that are the hallmarks of Parkinson's disease, Alzheimer's disease, and Huntington's disease.

"These results suggest a molecular link between the presence of inclusions and neuronal loss that is shared across a spectrum of neurodegenerative disease," notes senior author, James Eberwine, PhD, co-director of the Penn Genome Frontiers Institute and the Elmer Holmes Bobst Professor of Pharmacology. "Identifying these links within the diseased microenvironment will open up novel avenues for therapeutic intervention. For example it is reasonable to now ask "Is this molecule a possible new biomarker for these neurodegenerative diseases?" says Eberwine.

Eberwine, co-first authors Anup Sharma, an MD-PhD student, Jai-Yoon Sul, PhD, Assistant Professor of Pharmacology, both from Penn, Linda M. Callahan, PhD, from the University of Rochester Medical Center, and colleagues, report their findings this week in the online journal PLoS One.

Neurodegenerative diseases are characterized by a number of features including the protein clumps called inclusions; decline of nerve-cell synapses; and the selective loss of the nerve cells themselves.

Elk-1 resides within multiple brain areas, both in the nucleus and the cell body. Interestingly, when it is present in extensions of nerve cells called dendrites, it can initiate the death of that neuron. With this in mind the team assessed whether there is a specific dendrite form of Elk-1 or a modified form called phospho-Elk-1 (pElk-1) that might be associated with a spectrum of human neurodegenerative diseases.

First, they determined the importance of this specific modification of Elk-1 on its ability to
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

0

GOOD

Page: 1 2

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Vision restoration therapy shown to improve brain activity in brain injured patients
3. Clinical depression linked to abnormal emotional brain circuits
4. Brain imaging reveals breakdown of normal emotional processing
5. Brain cells work differently than previously thought
6. Vaccine Stops Alzheimers Brain Tangles
7. Research may unlock mystery of autisms origin in the brain
8. Scientists Spot Brains Free Will Center
9. Free will takes flight: how our brains respond to an approaching menace
10. Alcoholics With Cirrhosis Have More Brain Damage
11. Brain Lesions Predict MS Progression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
3 brain diseases linked by toxic form of same neural protein
(Date:5/19/2013)... Actos lawsuit claims continue ... in U.S. District Court, Western District of Louisiana. ... the Court has modified the litigation’s Bellwether Nomination process, ... than four. The next Status Conference in the federal ... re: Actos Product Liability Litigation, MDL No. 2299) , ...
(Date:5/19/2013)... May 19, 2013 The muscles in ... their functionality and one of the biggest and most ... nervous system. The peripheral system comprises of peripheral nerves ... cord. These nerves ensure that the limbs and hands, ... when these nerves get damaged due to trauma or ...
(Date:5/19/2013)... 19, 2013 Today, Zane Benefits, ... business health insurance . Zane Benefits, which provides ... health benefits, is the leader in health care ... reimbursement arrangements . , According to Zane Benefits’ ... intrinsically know the value of small business health ...
(Date:5/19/2013)... May 19, 2013 Grinding your teeth ... losing sleep, or annoying your spouse. At the same ... CNY Central (“Snoring and Teeth Grinding Could Be a ... teeth grinding can be hard to prevent. Apparently, Obstructive ... and one of its symptoms is a habit of ...
(Date:5/19/2013)... (PRWEB) May 19, 2013 According ... Market Analysis and Forecast (2013 – 2018): By ... Defense, Industrial)); Technology (CCD, CMOS, Contact IS, Infrared, ... of image sensor market was $8.00 billion in ... in 2018, at an estimated CAGR of 3.84% ...
Breaking Medicine News(10 mins):Health News:Actos Lawyers at Bernstein Liebhard LLP Note Issuance of New Case Management Order in Federal Actos Bladder Cancer Litigation 2Health News:Actos Lawyers at Bernstein Liebhard LLP Note Issuance of New Case Management Order in Federal Actos Bladder Cancer Litigation 3Health News:Ultimate Neuropathy Support System Launched by Neuracel - Reaching New Heights in Herbal Medication for Peripheral Neuropathy 2Health News:Zane Benefits Publishes New Information on Small Business Health Insurance 2Health News:Zane Benefits Publishes New Information on Small Business Health Insurance 3Health News:Dr. Kanani, Woodland Hills Dentist: Dangers of Tooth Damage and Obstructive Sleep Disorder 2Health News:Dr. Kanani, Woodland Hills Dentist: Dangers of Tooth Damage and Obstructive Sleep Disorder 3Health News:Image Sensors Market to Reach $10.75 Billion by 2018 at a CAGR of 3.84% - New Report by MarketandMarkets 2Health News:Image Sensors Market to Reach $10.75 Billion by 2018 at a CAGR of 3.84% - New Report by MarketandMarkets 3
... a special supplement, "Evaluation of the American Academy of ... Annals of Family Medicine reports on the results ... medical home concept in primary care practices. ... in 36 diverse U.S. primary care practices, an independent ...
... ... radio listeners on The Penn Project Show that, “The obesity crisis and related problems, such ... America needs to reverse that pro-inflammatory trend with anti-inflammatory diets, such as the Zone Diet." ... New Haven, CT (Vocus) ...
... ... Hispanic families found that untreated tooth decay in mothers almost doubled the odds of tooth ... and their children, the authors say. , ... (Vocus) June 15, 2010 -- A UCSF study examining the oral health of ...
... in wiring previously thought to be fixed , TUESDAY, ... fixed in early life, and circuits in the adult ... study involving mice. , U.S. researchers found that neurons ... alter their relationships with one another after single whiskers ...
... study led by UNC researchers that looks at newly diagnosed lung ... the first to give reasons why patients don,t go to lung ... most profound finding was the fact that African Americans with two ... four out of 100, whereas white patients in the same situation ...
... for those with MRSA in respiratory tract, study shows ... patients with methicillin-resistant staphylococcus aureus (MRSA) in their respiratory ... drug-resistant bacteria, researchers have found. , The new study, ... Journal of the American Medical Association , included 19,833 ...
Cached Medicine News:Health News:Results of first national demonstration project to implement patient-centered medical home released 2Health News:Results of first national demonstration project to implement patient-centered medical home released 3Health News:Results of first national demonstration project to implement patient-centered medical home released 4Health News:Results of first national demonstration project to implement patient-centered medical home released 5Health News:Results of first national demonstration project to implement patient-centered medical home released 6Health News:Results of first national demonstration project to implement patient-centered medical home released 7Health News:Clear Channel's “Penn Project” Features Dr. Barry Sears, Zone Diet Creator, About Obesity in America 2Health News:If Mother Has Tooth Decay, Odds Increase That Child Does Too 2Health News:If Mother Has Tooth Decay, Odds Increase That Child Does Too 3Health News:UNC study helps explain why black patients with lung cancer have surgery less often than whites 2Health News:UNC study helps explain why black patients with lung cancer have surgery less often than whites 3Health News:Drug-Resistant Staph Threatens Cystic Fibrosis Patients 2
(Date:5/19/2013)... , May 19, 2013  The non-surgical ... low temperature radiofrequency (RF) energy is effective in ... or reduces the need for medication 10 years ... presented today at the Digestive Disease Week (DDW) ... Florida . "The sustained ...
(Date:5/18/2013)... 2013 Although colonoscopy exams prevent many colon ... sensitive method for detecting colorectal cancers 2 , the ... 3 . EndoChoice ® Inc. today unveiled research ... the accuracy of this procedure and greatly reduces the ... discussing these clinical trial results and featuring the Fuse ...
(Date:5/18/2013)... May 18, 2013 The Open Paradigm ... Occupy Psychiatry , and leading organizations ... announces a social media campaign showcasing video testimonials ... model, which focuses on pathology and illness rather ... the American Psychiatric Association,s (APA) rollout of its ...
Breaking Medicine Technology:Stretta Procedure for GERD: Successful 10 Year Follow-Up Data Presented at Digestive Disease Week--Sustained Improvement, Long-Term Efficacy 2Stretta Procedure for GERD: Successful 10 Year Follow-Up Data Presented at Digestive Disease Week--Sustained Improvement, Long-Term Efficacy 3New Study Shows Full Spectrum Endoscopy Procedure Reduces The 'Miss Rate' of Adenomas During Colonoscopy 2New Study Shows Full Spectrum Endoscopy Procedure Reduces The 'Miss Rate' of Adenomas During Colonoscopy 3New Social Media Campaign Features Stories Of Individuals Who Rejected Psychiatric Diagnoses 2New Social Media Campaign Features Stories Of Individuals Who Rejected Psychiatric Diagnoses 3
Liquichek™ Ethanol/Ammonia Control is a liquid product used to monitor ethanol and ammonia test procedures in the clinical laboratory....
Liquichek Autoimmune Controls are individual controls for monitoring the performance of autoimmune assays....
Lyphochek Assayed Chemistry Control requires no special diluent and has good reconstituted stability for enzymes and CO2. It is assayed for most major instruments and methodologies....
Lyphochek Benzo/TCA Control Set A is ideal for monitoring HPLC methods for identification and quantitation of benzodiazepines and tricyclic antidepressant drugs....
Medicine Products: