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3 Mass. General researchers among recipients of Clinical Research Achievement awards
Date:4/18/2013

Awards. More information on BrainGate is available at http://www.braingate2.org.

  • Keith Flaherty, MD, MGH Cancer Center, for a New England Journal of Medicine paper reporting that combined treatment with two kinase inhibitors dabrafenib and trametinib delayed the development of treatment resistance in metastatic melanoma patients with tumors driven by mutations in the BRAF gene, which accounts for about half the cases of the deadly skin cancer. The phase I/II study, which found that combination treatment delayed resistance about four months longer than treatment with dabrafenib alone, is being followed with a larger phase II trial. A news release describing this study may be accessed at http://www.massgeneral.org/about/pressrelease.aspx?id=1274.

  • Michael Talkowski, PhD, MGH Center for Human Genetic Research, for two papers. The first, published in Cell, identified 33 genes associated with autism and related disorders, 22 for the first time, using a gene-sequencing method that detects the location of abnormalities in which DNA segments are moved within the same chromosome or exchanged with segments in other chromosomes, leaving the overall size of the chromosomes unchanged. A news release describing this paper may be accessed at http://www.massgeneral.org/about/pressrelease.aspx?id=1460. The second paper, published in the New England Journal of Medicine, described use of the sequencing method to accurately determine the genetic basis of a prenatally detected structural abnormality.

    Additional award recipients are from Yale University School of Medicine, Columbia University, Johns Hopkins School of Medicine, the University of North Carolina at Chapel Hill, the Universi
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  • Contact: Sue McGreevey
    smcgreevey@partners.org
    617-724-2764
    Massachusetts General Hospital
    Source:Eurekalert

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