Navigation Links
3-Drug Combo Reduces Nausea After Chemo
Date:5/11/2009

Study finds adding casopitant mesylate to regimen cuts side effects

MONDAY, May 11 (HealthDay News) -- The addition of the drug casopitant mesylate (CM) to the conventional two-drug regimen of dexamethasone and ondansetron greatly reduces chemotherapy-induced nausea and vomiting (CINV) in patients undergoing highly emetogenic chemotherapy (HEC), a new study concludes.

HEC is used to treat many types of solid tumor cancers, including colorectal and pancreatic cancer. Drugs such as dexamethasone and ondansetron are effective in reducing CINV in the first 24 hours after chemotherapy but only provide moderate relief during the delayed phase (24 to 120 hours after chemotherapy).

The phase 3 study included 810 patients who were receiving dexamethasone and ondansetron after undergoing HEC. They were randomly selected to also receive either a placebo (269 patients), a single 150-milligram oral dose of CM (271), or three-day intravenous plus oral CM (90-mg intravenous on the first day plus 50-mg oral on the second and third days).

The study found that 86 percent of patients in the single oral CM group and 80 percent of those in the intravenous plus oral CM group achieved a complete response (no vomiting, retching or use of rescue medications) for the first 120 hours after their first cycle of HEC treatment, compared with 66 percent of patients in the placebo group.

"A three-drug regimen including a single oral dose or three-day intravenous plus oral regimen of casopitant mesylate plus dexamethasone and ondansetron significantly reduced CINV events in patients receiving HEC compared with a two-drug regimen of dexamethasone and ondansetron," wrote Steven Grunberg, a professor at the University of Vermont, Burlington, and colleagues.

The study appears online and in the June print edition of The Lancet Oncology.

More information

The U.S. National Cancer Institute has more ab
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. 3-drug combination extremely promising as first-line therapy for multiple myeloma
2. 3-Drug Combo Improves Advanced Pancreatic Cancer Outcomes
3. 3-drug chemotherapy combination increases organ preservation in patients with larynx cancer
4. Radiation and drug combo helps boost efficacy of lung cancer treatment
5. Aerobic, Weight Training Combo Best Against Diabetes
6. New antibiotic drug combo to speed up treatment of tuberculosis
7. Drug Combo Helps Fight Marfan Syndrome
8. Drug Combo Blocks Pain Without Impairing Movement
9. Two-Drug Combo Fights Brain Tumors
10. CPR, Defibrillator Combo Boosts Cardiac Incident Survival
11. Drug Combo Boosts Multiple Myeloma Survival
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
3-Drug Combo Reduces Nausea After Chemo
(Date:3/27/2015)... Kansas City, Mo (PRWEB) March 27, 2015 ... common complications for patients undergoing percutaneous coronary intervention ... Ironically, studies have observed a “risk-treatment paradox,” in ... to gain from treatment are treated less often ... , Researchers at Saint Luke’s Mid America Heart ...
(Date:3/27/2015)... 2015 Ticket Down is a reputable source for ... After a phenomenal and highly successful live tour last year, ... out on tour again in 2015 and they will be visiting ... April 29th in New York City at the cozy Beacon Theatre ... on May 10th. , Fans of the hit show can look ...
(Date:3/27/2015)... BC (PRWEB) March 27, 2015 According ... ( http://www.idataresearch.com ), the plate and screw market in ... in the generic plate and screw segment. Price decreases ... market. Despite representing almost 50% of the total European ... to decrease the total market value, year after year. ...
(Date:3/27/2015)... The report “CountryFocus: Healthcare, Regulatory and Reimbursement Landscape ... and analysis of the healthcare, regulatory and reimbursement landscape ... 2013 amounted to 316.1 million, having grown at a ... The country’s increasingly elderly population and corresponding increase in ... the growth of the pharmaceutical market, which was worth ...
(Date:3/27/2015)... CA (PRWEB) March 27, 2015 GrassrootsHealth, ... its Protect Our Children (POC) NOW! vitamin D demonstration ... Medical University of South Carolina (MUSC), and will soon ... be available at no cost to a minimum of ... who live within these two service areas. The project ...
Breaking Medicine News(10 mins):Health News:Precision Medicine Improves Use of Bleeding Avoidance Strategies and Reduces Bleeding in Patients Undergoing Percutaneous Coronary Intervention 2Health News:Precision Medicine Improves Use of Bleeding Avoidance Strategies and Reduces Bleeding in Patients Undergoing Percutaneous Coronary Intervention 3Health News:Nashville Live in Concert Tickets in New York, Boston, Washington, DC, Chicago, Minneapolis, San Francisco, Los Angeles and Phoenix Now On Sale at TicketDown.com 2Health News:Titanium Trauma Treatment Devices in Europe Becoming More Affordable, Decreasing Market Value: Group Purchasing Further Eroding Selling Prices 2Health News:Titanium Trauma Treatment Devices in Europe Becoming More Affordable, Decreasing Market Value: Group Purchasing Further Eroding Selling Prices 3Health News:US Pharmaceutical Market worth $548.4 billion by 2020 Says a New Report Available at RnRMarketResearch.com 2Health News:US Pharmaceutical Market worth $548.4 billion by 2020 Says a New Report Available at RnRMarketResearch.com 3Health News:US Pharmaceutical Market worth $548.4 billion by 2020 Says a New Report Available at RnRMarketResearch.com 4Health News:GrassrootsHealth Moves Vitamin D into Practice with Pregnant Women 2Health News:GrassrootsHealth Moves Vitamin D into Practice with Pregnant Women 3Health News:GrassrootsHealth Moves Vitamin D into Practice with Pregnant Women 4
... categories for// printed letters and sounds, says a new study. ... filter out visual disturbances that may obscure the pattern of ... scientists from University of Southern California, US, brings out a ... dyslexic brain. ,Dyslexia is a learning disorder in ...
... lose knee lubrication following an injury to the knee. This ... of Rhode Island had identified a way to find out ... after a knee injury, in order to find out whether ... ,Although knee injury is considered to be a risk factor ...
... based study had found that children are more exposed ... anywhere else. ,Allergens that are commonly found indoor ... dust and dust mites, cockroaches and pollens. These may ... and various other diseases. Some of the symptoms experienced ...
... People who have survived cancer may have higher risks ... ,Researchers from University of Southern California had found ... long life have twice as much risk as their ... have studied 702 survivors of cancer and their twins ...
... in conceiving and// delivering world’s first baby born from ... the baby had her eggs collected from her, frozen ... fertilized from sperms of her partner through in-vitro fertilization ... in her uterus, which she carried to a full ...
... to air pollutions of big// cities may harm their ... of polluted air of the metros can change the ... from the cars, trucks, buses, tobacco smoke, combustion etc ... of the fetus. , ,The research conducted by ...
Cached Medicine News:
(Date:3/26/2015)... 26, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" ... focus on Omega-3 therapies for cardiovascular disease and overall ... 763,752 common shares of the Corporation (the "Common Shares"). ... period of December 5 th , 2014 to March ... that is due on or before April 1, 2015. ...
(Date:3/26/2015)... 26, 2015 "Whether it,s our family, our ... In a single sentence, Dr. Anthony ... at Pfizer,s Centers for Therapeutic Innovation (CTI), ... progress at America,s biopharmaceutical companies. CTI,s ... academia, patient foundations and the National Institutes of Health ...
(Date:3/26/2015)... Mich. , March 26, 2015 Cardiologists ... have performed the Midwest,s first commercial implant of a ... for patients with non-valvular atrial fibrillation. The Watchman Left ... use of blood-thinning warfarin medication to reduce the risk ... common heart rhythm disorder affecting more than 5 million ...
Breaking Medicine Technology:Pivotal Therapeutics announces payment of interest on outstanding convertible notes 2Collaboration for Cures: Teaming Up to Advance Science and Save Lives 2Beaumont Hospital, Royal Oak among first to offer alternative to blood-thinning medications for atrial fibrillation 2Beaumont Hospital, Royal Oak among first to offer alternative to blood-thinning medications for atrial fibrillation 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: