Navigation Links
23andMe discovers genetic variant that may protect those at risk for Parkinson's disease
Date:10/25/2011

MOUNTAIN VIEW, CA (October 25, 2011) 23andMe, Inc., a leading personal genetics company, has announced the first-time discovery of the potentially protective nature of the gene serum/glucocorticoid regulated kinase 1 (SGK1) which appears to be protective against a high-risk leucine-rich repeat kinase 2 (LRRK2) mutation for Parkinson's disease (PD).

The LRRK2 gene is recognized as a significant risk factor for Parkinson's disease. Of the approximately 1 in 10,000 people who carry a mutation called G2019S on the LRRK2 gene, about half develop Parkinson's disease. 23andMe has a large cohort of individuals who carry the G2019S mutation but surprisingly, do not have Parkinson's. In examining this cohort, 23andMe discovered the potentially protective nature of SGK1.

In a program funded by a $500,000 grant from The Michael J. Fox Foundation for Parkinson's Research, The Scripps Research Institute is investigating SGK1 and LRRK2, seeking to identify a new and potentially vital therapeutic target for Parkinson's disease.

The SGK1 finding was possible due to the magnitude of 23andMe's very active research community. The company currently has 125,000 genotyped customers, and nearly 90 percent have opted-in to participate in the company's Institutional Review Board-approved research. 23andMe has amassed the single largest Parkinson's research cohort in the world, which now comprises more than 6,000 participants and includes one of the largest cohorts of individuals carrying the pathogenic mutations in the LRRK2 gene.

In addition to genetic data, the company also compiles phenotypic (survey) data from research participants, which provides researchers with important insights into the interplay between genetics and overall health. "The 23andMe research platform can efficiently identify healthy individuals with rare genetic variants. Finding them is akin to finding a needle in a haystack and can only be identified with large databases like 23andMe," stated 23andMe CEO Anne Wojcicki. "These individuals are extremely valuable for us to study as they provide insights into why some people do not develop disease despite having high-risk genetic factors. This could lead to new drug targets or diagnostics."

"The 23andMe Parkinson's initiative has proven the tremendous potential in leveraging DNA technology, the Internet, and patient participation to accelerate findings that enhance our understanding of Parkinson's disease," said Todd Sherer, CEO of The Michael J. Fox Foundation. "The SGK1 discovery, while still early-stage, is a promising outcome of this unique research platform, and holds potential to inform a therapeutic approach for Parkinson's. We are eager to see the results of the continued investigation of SGK1 by Scripps."

23andMe first assembled its Parkinson's disease research initiative in June 2009. Within an 18-month period, 23andMe assembled and analyzed genetic data from more than 3,400 Parkinson's patients and successfully replicated the top 20 previously known genetic associations with Parkinson's disease in addition to determining new genetic associations for Parkinson's. Those findings were published in PLoS Genetics in June 2011. That study identified two novel loci, rs6812193 near SCARB2 and rs11868035 near SREBF1/RA11 and replicated those loci in an independent data cohort from the National Institute of Neurological Disease and Stroke (NINDS) database.


'/>"/>

Contact: Jane E. Rubinstein
jrubinstein@rubenstein.com
212-843-8287
23andMe Inc.
Source:Eurekalert  

Related medicine news :

1. 23andMe launches myeloproliferative neoplasms research initiative
2. 23andMe database surpasses 100,000 users
3. Louisiana State University Health Sciences Center research discovers key to survival of brain cells
4. UNH researcher discovers research manipulated to support pro-eugenic beliefs
5. Research discovers genetic link to Barretts esophagus, esophageal cancer
6. Expert discovers simple method of dealing with harmful radioactive iodine
7. UCSF team discovers key to fighting drug-resistant leukemia
8. UCSF team discovers new way to predict breast cancer survival and enhance effectiveness of treatment
9. OHSU Doernbecher discovers new approach to drug resistance in aggressive childhood cancer
10. MU chemist discovers shortcut for processing drugs
11. deCODE discovers genetic markers that improve the power of PSA testing for detecting prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
23andMe discovers genetic variant that may protect those at risk for Parkinson's disease
(Date:5/28/2017)... ... 2017 , ... HYPERAMS, LLC announced it will perform the inventory ... Lima, Ohio. The sale began this week and the inventory is expected to sell ... uniforms, and medical accessories, including blood pressure cuffs, stethoscopes, CPR masks, as well as ...
(Date:5/27/2017)... TX (PRWEB) , ... May 27, 2017 , ... Hate visiting the dentist? You should ... you'll need to take care of your teeth at home. Here are some dental tips ... after meals. Keep a small toothbrush in your work desk or a locker at school ...
(Date:5/26/2017)... ... 26, 2017 , ... The American Parkinson Disease Association’s ... grant submissions all vying for nearly $1,000,000 in funding that will be awarded ... American Parkinson Disease Association (APDA) is focused on advancing scientific research that will ...
(Date:5/26/2017)... ... May 26, 2017 , ... A new analysis of community ... healthiest seniors are located in the Midwest. With the average cost of healthcare rising ... are concerned with both the quality and affordability of where they live. An annual ...
(Date:5/26/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in Abilene, ... Agreements being discussed by President Donald Trump and the rest of the world. Donald ... up peace talks in the continuous battle between Israel and Palestine. The world’s eyes ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... May 10, 2017  The Corporate Whistleblower Center ... of sleep therapy clinics to call us anytime ... clinic is involved in a substantial scheme to ... hearing from an employee of a medical equipment ... scheme to provide medical practice groups with extra ...
(Date:5/10/2017)... 2017 CSSi, the global leader in patient ... industry, is proud to announce the launch of its ... features both enriched content and a customized layout that ... company,s already well-established position as the top global patient ... many months of hard work, we are delighted to ...
(Date:5/9/2017)... , May 9, 2017  Demonstrating its commitment ... of directors for the Pharmaceutical Research and Manufacturers ... membership. Biopharmaceutical companies will now have to meet ... to be eligible to join PhRMA. ... board is sending a clear message that being ...
Breaking Medicine Technology: