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2011 Louis-Jeantet Prize for Medicine
Date:1/26/2011

d conjugation enzymes, and to define their various functions.

The German researcher discovered a "molecular switch", which acts through protein modification of the protein PCNA (Proliferating Cell Nuclear Antigen) by ubiquitin and a related protein called SUMO (Small Ubiquitin-like MOdifier). This "PCNA switch" facilitates flawless duplication of the genome and also controls genetic mutations, such as those arising from the effects of UV light. Its role is fundamental, for errors in the process of DNA duplication cause genome instability, which in turn results in ageing and in the development of cancers.

Stefan Jentsch's discoveries have medical implications since defective ubiquitylation is the cause of numerous human diseases, from breast cancer to Fanconi anemia and Xeroderma pigmentosum.

Edvard and May-Britt Moser

Edvard Moser was born 1962 in lesund and May-Britt Moser in 1963 in Fosnavg, Norway. Both studied several different disciplines, in particular mathematics, statistics, computer programming, neurobiology and psychology at the University of Oslo, where they received doctorates in neurosciences in 1995, followed by post-doctoral training in the United Kingdom. On their return to Norway in 1996, they were nominated as associate professors in biological psychology at the Norwegian University of Science and Technology (NTNU) in Trondheim. They are now professors of neurosciences at the Faculty of Medicine of this university. At this same university, they founded in 2002 the Centre for the Biology of Memory, and in 2007 the Kavli Institute for Systems Neuroscience, where they hold the positions of Director and Co-director respectively.

Edvard and May-Britt Moser are both fellows of the Norwegian Academies of Sciences and Technological Sciences, as well as of various other scientific bodies. They have received several distinctions, in particular the W. Alden Spencer Award of Columbia University in 2005, the Lil
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Contact: Prof. Bernard C. Rossier
bernard.rossier@unil.ch
41-216-925-351
European Molecular Biology Organization
Source:Eurekalert

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