2010 AAAS Mentor Award goes to Dr. Joseph M. DeSimone of the University of North Carolina at Chapel Hill, and North Carolina State ... (mistry Edward T. Samulski wrote: Joe is...)

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2010 AAAS Mentor Award goes to Dr. Joseph M. DeSimone of the University of North Carolina at Chapel Hill, and North Carolina State University

Date:2/16/2011

mistry Edward T. Samulski wrote: "Joe is unique in that he is a kind of alchemist: he can see the treasure hidden in the stone, whether the stone is a research idea or a human being."

Dr. DeSimone received his B.S. degree in chemistry in 1986 from Ursinus College and then earned his doctoral degree in chemistry in 1990 from the Virginia Polytechnic Institute and State University. In 2005, DeSimone was elected into the National Academy of Engineering and the American Academy of Arts and Sciences. He is the founding director for both the UNC Institute for Advanced Materials, Nanoscience and Technology, and the UNC Institute for Nanomedicine. He also serves as co-director of the Carolina Center for Cancer Nanotechnology Excellence.

Dr. DeSimone's team is co-opting the fabrication technologies of the microelectronics industry to make new medicines and vaccines. He has developed a method for engineering drug particles that target disease within the body, while avoiding healthy cells. The technique, called PRINT, for "Particle Replication in Non-wetting Templates," lets researchers fabricate particles in a highly precise way, controlling their shape, size, composition, and function. The work shows promise for supporting the development of therapies for cancer prevention, diagnosis and treatment.

He has likened the fabrication system to a nano-sized ice cube tray, which can be filled with the liquid precursors to medicines and vaccines, which then solidify into particles. Unlike other particle fabrication techniques, PRINT is compatible with a variety of next-generation agents used for cancer therapy, detection and imaging, including various "cargos" such as DNA, proteins, chemotherapy drugs, biosensor dyes, radio-markers, and contrast agents.

He recently discussed his research with an EarthSky reporter. "One of the challenges with a solid tumor like pancreatic tumors is that not too much of the drug actually gets into the tumor," he explained. "So we're
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Contact: Katharine Zambon
kzambon@aaas.org
202-326-6434
American Association for the Advancement of Science
Source:Eurekalert

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