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2009 DeLee Humanitarian Award goes to Marshall Lindheimer, M.D., of the University of Chicago
Date:2/23/2009

aintenance during pregnancy, Lindheimer is widely known for his research on preeclampsia, a form of hypertension that remains a leading cause of maternal and fetal mortality worldwide.

In collaboration with Adrian Katz he described how the kidney reabsorbs the large increases in filtered sodium during pregnancy. With another University of Chicago colleague, Edward Ehrlich, Lindheimer elucidated the roles of the hormones aldosterone and progesterone in sodium and potassium regulation during pregnancy.

Working with John Davison, of Newcastle upon Tyne University, England, Lindheimer mapped out how regulation of the hormone vasopressin affected fluid retention during pregnancy. Understanding this process led them to predict the existence of an as-yet-unrecognized disease, now known as "transient diabetes insipidus during pregnancy." After finding such patients they were able to treat them.

More recently, Lindheimer focused on clinical trials and translational studies designed to prevent preeclampsia, such as a large multicenter randomized trials testing low-dose aspirin and supplemental dietary calcium to prevent this disease. He also was involved in a large observational trial centered in underdeveloped nations to determine if measuring circulating antiangiogenic proteins could predict preeclampsia.

"By bringing the subject of the kidney and pregnancy to the attention of internists and obstetricians in a readable and comprehensible way, and by his own contributions to our collective base of knowledge, he has made an outstanding contribution that has directly impacted the care of patients with renal disease and changed the clinical practice of nephrology," said Arthur Herbst, MD, Joseph B. DeLee Distinguished Service Professor Emeritus of obstetrics and gynecology at the University of Chicago.

The author of more than 250 original articles, 115 chapters and 7 edited texts, Lindheimer's contributions have earned him sever
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Contact: John Easton
john.easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
Source:Eurekalert

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