Navigation Links
2008 AAAS Newcomb Cleveland Prize recognizes science paper on limb regeneration in newts
Date:2/11/2009

A United Kingdom research team's discovery of a new molecular cue that promotes limb regeneration in newts a finding that could help guide the field of regenerative medicine received the 2008 Newcomb Cleveland Prize of the American Association for the Advancement of Science (AAAS).

The Association's oldest prize, now supported by Affymetrix, the Newcomb Cleveland Prize annually recognizes the author or authors of an outstanding paper published in the Research Articles or Reports sections of the journal Science between June and the following May.

When an amphibian's limb is severed, a variety of cell types revert to their earlier stem cell form and then proliferate at the tip of the stump to form a mass of undifferentiated cells, the "blastema," from which the new limb grows. The formation of the blastema requires signaling molecules from nearby nerves, though this process has been poorly understood.

Five Science authors Anoop Kumar, James W. Godwin, Phillip B. Gates, and Jeremy P. Brockes of University College London, along with A. Acely Garza-Garcia of the U.K.'s National Institute for Medical Research, were recognized for their article, entitled "Molecular Basis for the Nerve Dependence of Limb Regeneration in an Adult Vertebrate." (Reference: Science, 2 November 2007, Vol. 318, no. 5851, pp. 772-777. DOI: 10.1126/science.1147710.)

The researchers reported that the protein nAG helps to stimulate the proliferation of the blastema cells. The protein is secreted by both nervous-system cells called Schwann cells and epidermal cells near the wound, which helps explain why nerves are required for blastema formation. Even when the nerve was severed beneath the stump tip, the authors were able to coax the formation of a blastema by artificially inducing cells to express the protein. The blastema was capable of generating a new limb with normal shape, though the limb wasn't fully functional and lacked normal nerve supply.

The prize was established in 1923 with funds donated by Newcomb Cleveland of New York City and was originally called the AAAS Thousand Dollar Prize. It is now known as the AAAS Newcomb Cleveland Prize, and its value has been raised to $25,000. The winner also receives a bronze medal, as well as complimentary registration and reimbursement for reasonable travel and hotel expenses to attend the AAAS Annual Meeting. Eligible Science papers include original research data, theory, or synthesis. They should represent a fundamental contribution to basic knowledge, or a technical achievement of far-reaching consequence. Winning nominations also should be a first-time publication of the author's own work.


'/>"/>

Contact: Molly McElroy
mmcelroy@aaas.org
202-326-6434
American Association for the Advancement of Science
Source:Eurekalert

Related medicine news :

1. Cleveland Clinic Launches Ground-Breaking Wellness Program To Reverse Effects of Common Chronic Diseases
2. Cleveland House a Sober living Resort, is Celebrating 7 Year Anniversary
3. Cleveland Clinic and Mubadala Healthcare Name CEO of Cleveland Clinic Abu Dhabi
4. Hip Replacement Patients at Possible Risk, Cleveland Law Firm Adds Zimmer Durom Cup Lawsuit Info on SpangLaw.com
5. U.S. Continues to Lag Behind European Countries in Teen Sexual Health - Cleveland Sex Ed Initiative Takes Promising Science-Based Approach
6. Solos Endoscopy, Inc. Receives Purchase Order from Cleveland Clinic
7. PR Newswire Provides Grant to Ronald McDonald House and Habitat for Humanity in Cleveland
8. LifeBanc Assists Cleveland Clinic in First Near Total Face Transplant in the United States
9. Cleveland Injury Attorneys Among 'The Best Lawyers in America'
10. University Hospitals in Cleveland Selects Solution Suite from Agilysys
11. The American Lung Association of Ohio Encourages Cleveland Residents to See Themselves Among The Many Faces of Influenza
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 ... characterized by frequent cessation in breathing. Oral appliances can offer significant relief to ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... the introduction of an innovative new design of the shoulder pad. The shoulder ... maximum comfort while controlling your pain while using cold therapy. By utilizing ice and ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... system that we intend to develop to enable prevention of a major side ... severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is FDA ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s ... the 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. ... Center for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health Literacy Innovations (HLI), ... software tool, and the Cancer Patient Education Network (CPEN), an independent professional organization ... a new strategic alliance. , As CPEN’s strategic partner, HLI will help ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Texas , Oct. 11, 2017  Caris Life ... focused on fulfilling the promise of precision medicine, today ... has joined Caris, Precision Oncology Alliance™ (POA) as its ... cancer centers, the St. Jude Crosson Cancer Institute will ... advance the use of tumor profiling, making cancer treatment ...
(Date:10/11/2017)... CHICAGO , Oct. 11, 2017  Hill-Rom Holdings, ... its Aspen Surgical facility in Las Piedras, ... surgical scalpels and blades. ... confirmed that the facility sustained minor structural damage, temporary ... Hurricane Maria. Repairs have been completed, manufacturing operations have ...
(Date:10/10/2017)...   West Pharmaceutical Services, Inc. (NYSE: WST), ... administration, today shared the results of a study highlighting ... intradermal administration of polio vaccines. The study results were ... 2017 by Dr. Ondrej Mach , Clinical Trials ... (WHO), and recently published in the journal Vaccine. ...
Breaking Medicine Technology: