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2008 AAAS Newcomb Cleveland Prize recognizes science paper on limb regeneration in newts
Date:2/11/2009

A United Kingdom research team's discovery of a new molecular cue that promotes limb regeneration in newts a finding that could help guide the field of regenerative medicine received the 2008 Newcomb Cleveland Prize of the American Association for the Advancement of Science (AAAS).

The Association's oldest prize, now supported by Affymetrix, the Newcomb Cleveland Prize annually recognizes the author or authors of an outstanding paper published in the Research Articles or Reports sections of the journal Science between June and the following May.

When an amphibian's limb is severed, a variety of cell types revert to their earlier stem cell form and then proliferate at the tip of the stump to form a mass of undifferentiated cells, the "blastema," from which the new limb grows. The formation of the blastema requires signaling molecules from nearby nerves, though this process has been poorly understood.

Five Science authors Anoop Kumar, James W. Godwin, Phillip B. Gates, and Jeremy P. Brockes of University College London, along with A. Acely Garza-Garcia of the U.K.'s National Institute for Medical Research, were recognized for their article, entitled "Molecular Basis for the Nerve Dependence of Limb Regeneration in an Adult Vertebrate." (Reference: Science, 2 November 2007, Vol. 318, no. 5851, pp. 772-777. DOI: 10.1126/science.1147710.)

The researchers reported that the protein nAG helps to stimulate the proliferation of the blastema cells. The protein is secreted by both nervous-system cells called Schwann cells and epidermal cells near the wound, which helps explain why nerves are required for blastema formation. Even when the nerve was severed beneath the stump tip, the authors were able to coax the formation of a blastema by artificially inducing cells to express the protein. The blastema was capable of generating a new limb with normal shape, though the limb wasn't fully functional and lacked norm
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Contact: Molly McElroy
mmcelroy@aaas.org
202-326-6434
American Association for the Advancement of Science
Source:Eurekalert

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