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2-virus link to prostate cancer
Date:7/31/2012

Two common viruses known to be associated with human cancers are both present and may even be collaborating with each other - in most male prostate cancers, a new study suggests.

The research involved examination of 100 specimens of normal, malignant and benign prostate samples from Australian men.

It revealed that both the human papilloma virus (HPV) and Epstein Barr virus (EBV) were present in more than half of the malignant cancers, as well as in a high proportion of benign and normal prostate samples.

Details of the study, led by Associate Professor Noel Whitaker and Professor James Lawson, of the University of New South Wales (UNSW) in Sydney, Australia, are published in the journal The Prostate.

The research team included other UNSW researchers and colleagues from the Department of Forensic Medicine Sydney South West Area Health Service and at Douglass, Hanly, Moir Pathology.

"Recent unpublished experimental evidence by other researchers suggests that HPV and EBV can collaborate to promote the survival and proliferation of cancer cells, so our findings may well have important implications for understanding and preventing prostate cancer," says Professor Whitaker.

"Significantly, in our prostate samples we found a high-risk strain known as HPV 18, which is known to be associated with other human cancers.

"HPV 18 is a common high-risk strain in Australia and is a specific target of the Gardasil vaccine now offered free to teenage girls to protect against cervical cancer.

"We note recent proposals to offer Gardasil to Australian teenage boys as well, with the aim of preventing the spread of the virus to women through sexual contact. If HPV 18 is also associated with prostate cancers, as our research suggests, vaccinating boys may yet prove to have an unexpected direct benefit for them as well."

Earlier research by Professor Whitaker's team has found that HPV is present in about 40% of breast cancers as well. The
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Contact: Bob Beale
bbeale@unsw.edu.au
61-411-705-435
University of New South Wales
Source:Eurekalert

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