Navigation Links
2 studies provide insight into stroke risk and prevention in young sickle cell anemia patients
Date:12/6/2010

Monthly blood transfusions combined with daily medication to remove the resulting excess iron remains the best approach for reducing the risk of recurrent strokes in young patients with sickle cell anemia, according to a preliminary analysis of a multicenter trial that includes St. Jude Children's Research Hospital.

The study compared the efficacy of two treatments for the potentially life-threatening problem of iron overload caused by chronic transfusion therapy. The transfusions are used to guard against additional strokes in young sickle cell anemia patients. The trial, known as SWiTCH or Stroke with Transfusion Changing to Hydroxyurea, was halted in May after an interim safety review determined the alternative therapy was not significantly better than the standard treatment at reducing iron buildup and was associated with an increased stroke risk.

Russell Ware, M.D., Ph.D., chair of the St. Jude Children's Research Hospital Department of Hematology and principal investigator of SWiTCH, discussed the results at the 52nd Annual Meeting of the American Society of Hematology. The meeting is being held December 4 -7 in Orlando, Fla.

Jonathan Flanagan, Ph.D., a staff scientist at St. Jude, presented results of another study that provide the first independent validation of an association between five common genetic variations and stroke risk in young sickle cell patients.

Between 70,000 and 100,000 individuals in the U.S. have sickle cell anemia. They make an abnormal hemoglobin molecule that sometimes takes on a twisted or sickle shape, disrupting blood flow and oxygen delivery throughout the body. Patients are vulnerable to a variety of problems, including organ damage, episodes of acute pain and stroke. Five to 10 percent of patients will suffer strokes before their 20th birthday. Up to 90 percent of patients will experience a recurrence.

Flanagan and his colleagues tried to validate earlier reports linking 38 genet
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Drug-like compound stops thyroid overstimulation in early NIH studies
2. Laboratory studies show promise for new multiple sclerosis treatment
3. A Little Alcohol May Help the Heart: Studies
4. Studies validate use of family health history as gold standard in disease risk assessment
5. Researchers find pathway that drives spread of pediatric bone cancer in preclinical studies
6. Practice-changing studies on how oncologists treat cancer to be presented at ASTRO Annual Meeting
7. Studies show everolimus-eluting stent implantation reduces restenosis and repeat revasculariztion
8. New studies highlight obesitys impact on gastrointestinal health
9. 2 studies present new data on effects of alcohol during pregnancy
10. Studies Tout Alternative HIV Regimens for Women, Babies
11. Hospital readmission studies: Influencing factors identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... Miami, FL (PRWEB) July 31, 2014 ... Guinness International Champions Cup Finals tickets at the Sun ... 2014 Guinness International Champions Cup is now underway. Residents and ... to be able to watch the Guinness International Champions Cup ... The eight teams competing in the tournament have been split ...
(Date:7/31/2014)... Daily Gossip indicates in its "Neuropathy Miracle" review ... problem. However, this is not a solution. , The ... Peter Bansby, who decided to reveal his method with ... world find a unique way of overcoming their health ... and cons from a full Neuropathy Miracle review, simply ...
(Date:7/31/2014)... Andrie, Inc. V. Dept. of Treasury, Mich. S. ... has made the determination that a purchaser of tangible goods ... was unable to prove during an audit that sales ... Court of Appeals decision on whether a purchaser bears the ... purchases from Michigan sellers. The Court states “in order to ...
(Date:7/31/2014)... Washington, New York (PRWEB) July 31, 2014 ... represents whistleblowers in qui tam cases, comments that whistleblowers ... an end to illegal employer activities that may cause ... recognizes that today is National Whistleblower Appreciation Day. , ... National Whistleblower Center , the Senate declared "National Whistleblower ...
(Date:7/31/2014)... Stamford, CT (PRWEB) July 31, 2014 You’re ... friends. So why have you suddenly developed chills and fever, ... exhaustion? If you suspect a flu-like illness, it could actually ... , Your risk of developing Lyme is greater than ... about 30,000 new cases occurred in the U.S. annually. But ...
Breaking Medicine News(10 mins):Health News:Guinness International Champions Cup Finals Tickets in Miami, FL Available at Ticket Down 2Health News:Guinness International Champions Cup Finals Tickets in Miami, FL Available at Ticket Down 3Health News:Neuropathy Miracle Review Reveals Peter Bansby's Unique Cure Method 2Health News:Taxpayer Failing To Prove Sales Tax Was Paid At Time Of Purchase Results In Use Tax Due 2Health News:Taxpayer Failing To Prove Sales Tax Was Paid At Time Of Purchase Results In Use Tax Due 3Health News:National Whistleblower Appreciation Day Declared to Ensure Recognition of Enormous Contribution to the Democracy by Whistleblowers, Parker Waichman LLP Comments 2Health News:National Whistleblower Appreciation Day Declared to Ensure Recognition of Enormous Contribution to the Democracy by Whistleblowers, Parker Waichman LLP Comments 3Health News:National Whistleblower Appreciation Day Declared to Ensure Recognition of Enormous Contribution to the Democracy by Whistleblowers, Parker Waichman LLP Comments 4Health News:Feel Like You Have A Summertime 'Flu'? It Could Be Lyme Disease 2Health News:Feel Like You Have A Summertime 'Flu'? It Could Be Lyme Disease 3
... always ideal for many with low risk disease, researchers ... patients with prostate cancer that has a low risk ... may be a suitable treatment option, according to a ... (or whether) to treat localized prostate cancer is controversial ...
... ... MD is now performing a new procedure at Baptist Medical Center in Jackson, Miss. ... referred to as a myomectomy, or fibroidectomy. , ... Jackson, MS (Vocus) June 18, 2010 -- Baptist Medical ...
... Poor kids in bilingual families need extra support, study ... children in poor families are at increased risk for ... summer holidays, according to the American Speech-Language-Hearing Association. , ... the summer, says the ASHA, which offers the following ...
... Rome, Italy, Friday 18 June 2010: There is significant ... terms of access to biological treatments for rheumatoid arthritis ... four continents presented today at EULAR 2010, the Annual ... Italy. Furthermore, findings from a separate study show that ...
... , ... In today’s back to school environment, many ... have seen on T.V. or the Internet to inquire about returning ... realize is that their work and military experience, training certificates, licenses ...
... consumption dropped, study found , FRIDAY, June 18 (HealthDay ... may reduce consumption and help lower levels of obesity ... suggests. , Researchers examined what happened during a time ... in Boston increased the price of regular soft drinks ...
Cached Medicine News:Health News:'Watchful Waiting' Often Best Strategy for Slow-Moving Prostate Cancer 2Health News:GYN Oncologist Uses da Vinci Surgical Robot to Preserve Fertility 2Health News:Country economy is a stronger predictor of therapy initiation 2Health News:College Equalizer Takes College Counseling Beyond the Status Quo to Help Adult Learners Find the Best School 2Health News:College Equalizer Takes College Counseling Beyond the Status Quo to Help Adult Learners Find the Best School 3Health News:People May Skip Soft Drinks Rather Than Pay More 2
(Date:7/31/2014)... Hovione today announced that its API plant in ... pre-approval inspection by the US Food and Drug Administration (FDA). ... Safety Officer, Ms. Britanny Terhar , lasted 5 days ... concluded on the 25 th . The inspection confirmed the ... Good Manufacturing Practices (GMP) and no Form 483 observations were ...
(Date:7/31/2014)... VIENNA , July 31, 2014 ... in New York results of AFF008, ... Parkinson,s disease. PD01A is the first therapy against the protein ... The Michael J. Fox Foundation for Parkinson,s Research ... and presented at the press conference on the impact a ...
(Date:7/31/2014)... 2014 Vermillion, Inc. (NASDAQ: VRML), a multivariate diagnostics ... a conference call on Thursday, August 14, 2014, at 4:30 ... ended June 30, 2014. Financial results will be issued in ... Chairman, President and CEO James LaFrance will host ... Date: Thursday, August 14, 2014 Time: 4:30 p.m. Eastern ...
Breaking Medicine Technology:Successful FDA Inspection at Hovione's API Manufacturing Plant in Cork, Ireland 2First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 2First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 3First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 4Vermillion Sets Second Quarter 2014 Conference Call for Thursday, August 14, 2014 2
... Life Technologies Corporation (NASDAQ: LIFE ) ... with GlaxoSmithKline Biologicals S.A. (GSK) to develop a diagnostic ... GSK candidate cancer immunotherapy. Specifically, Life will develop a ... candidate designed to identify patients likely to benefit from ...
... (Cayman) Inc. (NYSE: WX ), a leading ... operations in China and the United States, today announced ... quarter of 2011 after the New York Stock Exchange ... Friday morning, November 11, 2011 Shanghai time). The earnings ...
Cached Medicine Technology:Life Technologies Signs Agreement with GlaxoSmithKline Biologicals S.A., Seeking Expanded Use of Platform Technologies into Companion Diagnostics 2Life Technologies Signs Agreement with GlaxoSmithKline Biologicals S.A., Seeking Expanded Use of Platform Technologies into Companion Diagnostics 3Life Technologies Signs Agreement with GlaxoSmithKline Biologicals S.A., Seeking Expanded Use of Platform Technologies into Companion Diagnostics 4WuXi PharmaTech Schedules Third-Quarter 2011 Earnings Release 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: