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2 studies find new genetic links to ovarian cancer risk
Date:9/19/2010

ral population who are at the greatest risk of developing ovarian cancer because they carry these newly discovered DNA variants can be identified and given closer surveillance to look for early signs of ovarian cancer when it is most treatable," says Berchuck. "It also suggests that preventive approaches could be targeted towards these women."

Ellen Goode*, PhD, a genetic epidemiologist at the Mayo Clinic College of Medicine and the lead author of one of the studies, says "additional research will be required to learn more about the specific genes and DNA changes in these DNA stretches that could be causing ovarian cancer," but she says the newly implicated regions of the genome also contain some familiar suspects.

"Common genetic 'typos' at 8q24 have already been shown to render some people vulnerable to prostate, colorectal, breast and bladder cancers, so it's not too surprising that there may be something there related to ovarian cancer," Goode said. "What is surprising is that we found that three of the most common SNPs for ovarian cancer lie quite a distance away from this bunch of troublemakers in an apparent gene desert which suggests they may be causing functional problems by a very different mechanism."

A second study** in the same issue of Nature Genetics found a region of DNA on chromosome 19 that also affects ovarian cancer risk. And a third study in the same issuefound that variation in this same region of chromosome 19 also increases the risk of breast cancer in women who already carry a faulty copy the BRCA1 gene*** on chromosome 17.

Researchers have known for some time that heritable mutations in the BRCA1 and BRCA2 genes can dramatically increase a woman's chances of developing breast and ovarian cancer, but these mutations only account for a small percent of ovarian cancers. Because DNA variations such as those described in these new studies are much more common in the general population than BRCA1 a
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Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-724-5343
Duke University Medical Center
Source:Eurekalert

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