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2 repressor genes identified as essential for placental development
Date:4/16/2012

e says.

"Here, we show that the repressors E2f7 and E2f8 are essential for the development of an intact, functional, placenta, and that they balance out the effects of the activating gene E2f3a," Leone says. "Because these two repressors are important for proliferation, they may also play an important role in suppressing tumor development."

For this study, Leone and his colleagues used animal models that lacked one or more of the three E2F genes in trophoblast stem cells, which give rise to the placenta.

Earlier work led by Leone has shown that in some cases, an E2F gene can be an activator in some tissues and a repressor in others.


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Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

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