Navigation Links
2 proteins play key roles in Burkitt's lymphoma
Date:3/7/2011

Burkitt's lymphoma is one of the most aggressive tumors affecting humans. Multiple alterations in genes that regulate cell proliferation rate explain its aggressive behavior.

A new study reveals new molecular insight into the understanding and treatment of Burkitt`s lymphoma. The new finding concentrates on a genetic locus -- a piece of DNA with one or more genes which is the specific location of a gene or DNA sequence on a chromosome -- called INK4a/ARF locus. This locus encodes two important tumor suppressor genes, p16 and p14, and is usually inactivated in human tumors by genetic mutations. By controlling p53 and Rb pathways, p14(ARF) and p16(INK4a) inactivation allow the cells to overcome anti-oncogenic barriers and proliferate in an uncontrolled manner. Researchers found that in Burkitt`s lymphoma, the locus is genetically unchanged but the product proteins are inactivated by epigenetic and posttranscriptional mechanisms.

The research was done by the Sbarro Health Research Organization Center for Biotechnology, a nonprofit research center for cancer, cardiovascular and diabetes research, located in the College of Science and Technology at Temple University in Philadelphia, PA, and the University of Siena in Siena, Italy and published in Cell Cycle.

"We discovered a completely new mechanism for INK4/ARF protein inactivation," said Annalisa Roberti, lead author of the paper. "Since in Burkitt`s lymphoma these two proteins are not inactivated at the genetic level, their inactivation could be pharmacologically reversible. The reactivation of p16 and p14 in our model and our ability to inhibit cell proliferation and induce apoptosis through the Rb- and p-53 pathways opens new prospects for the understanding and treatment of Burkitt's lymphoma."

"This is an additional piece of the complex puzzle in which the Rb family, which includes Rb2/p130, plays an important role. The new discovery in our laboratory presents additional evidence that more and more, Rb is becoming to be viewed as a guardian of our genome," notes Antonio Giordano, M.D., Ph.D., Founder of SHRO and Director of the Sbarro Institute for Cancer Research and Molecular Medicine.


'/>"/>

Contact: Ilene Raymond Rush
irush@shro.org
215-470-2998
Sbarro Health Research Organization
Source:Eurekalert

Related medicine news :

1. SIBLING proteins may predict oral cancer
2. Proteins May Predict Spread of Colon Cancer
3. Proteins may point to alcohol use test
4. Newly identified proteins critical to FA pathway DNA repair function
5. Proteins in unroasted coffee beans may become next-generation insecticides
6. UD team develops new method for producing proteins critical to medical research
7. US Whey Proteins Market to Reach 472.3 Million Pounds by 2015, According to New Report by Global Industry Analysts, Inc.
8. Expression of certain transporter proteins may predict resistance to drug therapy
9. Hydrophobic proteins: Potential biomarkers for colorectal cancer
10. Researchers find function of proteins that can enhance the progression of viruses and cancer cells
11. Misfolded neural proteins linked to autism disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... February 10, 2016 , ... A ... Safety Congress and Expo event March 9-11, 2016. Hosted by Ohio's Bureau of ... , As the longest running and largest worker's compensation event in Ohio, ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... Everseat digital self-scheduling readily available to physicians. The integration will enable Allscripts ... and select appointments via Everseat’s free mobile app. , The partnership gives Everseat ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... Jacksonville, FL 32224, February 26th: Amateur & Professional Divisions - Time: 7:00pm ... 7:00pm – 10:00pm | Ticket Prices $30, Social Media: http://www.USPoleSportsFed.org , ...
(Date:2/10/2016)... ... ... Workrite Ergonomics, who is celebrating their 25th year of business in 2016, is ... recognized leader in their industry. , "We are very proud of our heritage and ... “Workrite recognized the importance of good ergonomics before most of our competition even knew ...
(Date:2/10/2016)... ... 2016 , ... Anxiety of older Americans over steep cost increases of prescription ... decade ago, according to The Senior Citizens League (TSCL). Since last ... with rapidly rising costs. “The implications are chilling, particularly for people with chronic ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... 2016 ALSP, Inc. announced that it has appointed ... Medical Affairs in preparation for its move into clinical trials ... CEO, stated, "We are pleased to welcome Dallas Hack ... with an individual of such practical knowledge and far-reaching experience ... deeply on his broad experience and success as a clinician ...
(Date:2/10/2016)... , Feb. 10, 2016 Intouch Solutions, a ... identified an industry-wide trend regarding the evolution of ... organizations to efficiently deliver compelling sales presentations via ... and another in 2015, Intouch uncovered that while ... devices and DSAs, many are not using them ...
(Date:2/10/2016)... 2016  Until recently, the options for reducing the ... the FDA approved the non-invasive Coolsculpting treatment, which removes ... originally approved in 2010 for the abdomen and this ... chin. With this add-on approval, the experts at Laser ... applicator, the CoolMini, to address smaller areas of fat. ...
Breaking Medicine Technology: