Navigation Links
2 proteins play key roles in Burkitt's lymphoma
Date:3/7/2011

Burkitt's lymphoma is one of the most aggressive tumors affecting humans. Multiple alterations in genes that regulate cell proliferation rate explain its aggressive behavior.

A new study reveals new molecular insight into the understanding and treatment of Burkitt`s lymphoma. The new finding concentrates on a genetic locus -- a piece of DNA with one or more genes which is the specific location of a gene or DNA sequence on a chromosome -- called INK4a/ARF locus. This locus encodes two important tumor suppressor genes, p16 and p14, and is usually inactivated in human tumors by genetic mutations. By controlling p53 and Rb pathways, p14(ARF) and p16(INK4a) inactivation allow the cells to overcome anti-oncogenic barriers and proliferate in an uncontrolled manner. Researchers found that in Burkitt`s lymphoma, the locus is genetically unchanged but the product proteins are inactivated by epigenetic and posttranscriptional mechanisms.

The research was done by the Sbarro Health Research Organization Center for Biotechnology, a nonprofit research center for cancer, cardiovascular and diabetes research, located in the College of Science and Technology at Temple University in Philadelphia, PA, and the University of Siena in Siena, Italy and published in Cell Cycle.

"We discovered a completely new mechanism for INK4/ARF protein inactivation," said Annalisa Roberti, lead author of the paper. "Since in Burkitt`s lymphoma these two proteins are not inactivated at the genetic level, their inactivation could be pharmacologically reversible. The reactivation of p16 and p14 in our model and our ability to inhibit cell proliferation and induce apoptosis through the Rb- and p-53 pathways opens new prospects for the understanding and treatment of Burkitt's lymphoma."

"This is an additional piece of the complex puzzle in which the Rb family, which includes Rb2/p130, plays an important role. The new discovery in our laboratory presents additional evidence that more and more, Rb is becoming to be viewed as a guardian of our genome," notes Antonio Giordano, M.D., Ph.D., Founder of SHRO and Director of the Sbarro Institute for Cancer Research and Molecular Medicine.


'/>"/>

Contact: Ilene Raymond Rush
irush@shro.org
215-470-2998
Sbarro Health Research Organization
Source:Eurekalert

Related medicine news :

1. SIBLING proteins may predict oral cancer
2. Proteins May Predict Spread of Colon Cancer
3. Proteins may point to alcohol use test
4. Newly identified proteins critical to FA pathway DNA repair function
5. Proteins in unroasted coffee beans may become next-generation insecticides
6. UD team develops new method for producing proteins critical to medical research
7. US Whey Proteins Market to Reach 472.3 Million Pounds by 2015, According to New Report by Global Industry Analysts, Inc.
8. Expression of certain transporter proteins may predict resistance to drug therapy
9. Hydrophobic proteins: Potential biomarkers for colorectal cancer
10. Researchers find function of proteins that can enhance the progression of viruses and cancer cells
11. Misfolded neural proteins linked to autism disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2017)... ... August 22, 2017 , ... PracticeMatch, a company that provides ... employers connect with physicians and advanced practitioners like nurse practitioners and ... in August through November of this year. The online career fairs will allow job ...
(Date:8/21/2017)... ... August 22, 2017 , ... The National Association ... 2017-2018 inductee into its VIP Woman of the Year Circle. She is recognized ... networking organization exclusively for professional women, boasting more than 850,000 members, a thriving ...
(Date:8/21/2017)... ... August 21, 2017 , ... FCPX LUT Monochromatic Volume 2 ... quickly and easily add washed color grades to footage. A LUT is a Lookup ... pixel’s color to the corresponding color indicated by the table. This pack comes with ...
(Date:8/21/2017)... Beach, California (PRWEB) , ... August 21, 2017 , ... ... raise money and awareness for Alzheimer’s Family Center. , Guests will be able ... from Newport Beach Plaza, Braised Lamb Shank with Fennel Dill Salad, Feta Cheese Sauce ...
(Date:8/21/2017)... ... August 21, 2017 , ... Duncan Insurance ... serving the people of Michigan. The new initiative fundraises for the Kalamazoo Humane ... very forefront of animal protection and welfare by addressing the root causes of ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... 7, 2017 Insightin Health, provider of ... and engagement, announced the selection of Michael ... Development, effective as of February 2017. In this role, ... strategy for our clients. Wood brings with him ... and business analytics within the healthcare industry. Wood ...
(Date:8/4/2017)... -- The search for test results that can be ... long been the goal of healthcare providers and the ... largest meeting of lab professionals and IVD firms this ... Kalorama Information.  The firm said scores of companies with ... and software were at the American Association for Clinical ...
(Date:8/2/2017)... 2, 2017  Life Flight Network and PeaceHealth Oregon Network ... patient care and operational efficiency for patients at hospitals in ... Cottage Grove , and Florence, ... and Life Flight Network work collaboratively to move patients who ... when a time sensitive emergency exists. ...
Breaking Medicine Technology: