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2 proteins compete for 1 port on a growth factor; 1 promotes metastasis, the other blocks it
Date:1/23/2014

"That a protein can find a receptor using its SH3 domain is an entirely new idea," Ladbury said. "There's a lot of background activity in cells, just to keep them ticking over and in the past we've kind of ignored what's happening there. Now we've shown that if these background activities are perturbed, they can lead to cancer."

The Ladbury group is pursuing these studies to quantify the respective amounts of Grb2, Plcγ1 and FGFR2 in cancer cell lines to assess what levels might be prognostic. In addition they are investigating other receptors for their potential to bind SH3-domain containing proteins to build up a bigger picture of what pathways are involved in maintaining the stable state in cells.


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Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

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2 proteins compete for 1 port on a growth factor; 1 promotes metastasis, the other blocks it
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