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2 new cost-effective ways to predict prostate cancer
Date:9/23/2011

f prostate specific antigen and investigated whether this correlated with later prostate cancer incidence and mortality.

During the 28 years of follow-up covered by the Heart Study, 170 men in the sample developed prostate cancer and 94 died from the disease. Measuring the antigen levels, the researchers found that stepwise increases in prostate-specific antigen predicted a 3-44 fold increased risk of prostate cancer and a 2-12 fold increased risk of prostate cancer mortality.

They also found that the absolute 10-year risk of prostate cancer was 11-22% in those with prostate-specific antigen levels of 4.01-10.00 ng/ml and 37-79% in those with levels above 10.00 ng/ml.

The ranges are wide and the higher risk for some men can be explained, Dr rsted will tell the congress. "The high risk for some men is probably due to some of the participants having already developed sub-clinical prostate cancer at the time of their entry to the study. These men would have had a shorter time from study entry to diagnosis and consequently, higher risk estimates."

The results could be used to target specific sections of the population for screening. "One of the major problems in prostate cancer is over-diagnosis. Furthermore, two large randomised studies have shown that the benefit of general screening for prostate cancer is limited," explains Dr rsted. "Our results indicate that physicians could focus screening efforts on men with higher baseline prostate specific antigen values while men with lower levels could avoid having frequent and unnecessary diagnostic examinations. This could reduce over-diagnosis and unnecessary treatment as well as reduce expenditure in already strained health systems," he says.

President of ECCO, Professor Michael Baumann, said: "These studies demonstrate how important it is to have good cancer registries and skilled cancer epidemiologists available. Large cancer registries, which contain high quality data and
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Contact: Saffina Rana
saffina.rana@europe.com
ECCO-the European CanCer Organisation
Source:Eurekalert

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