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2 new cost-effective ways to predict prostate cancer
Date:9/23/2011

Stockholm, Sweden: Two new risk indicators for prostate cancer will be unveiled at the 2011 European Multidisciplinary Cancer Congress [1] today (Saturday).

Led by Dr David rsted at the Copenhagen University Hospital, Herlev, the first study shows that men diagnosed with benign prostate enlargement have an increased risk of developing and dying from prostate cancer. The second study shows that monitoring prostate-specific antigen levels can be used to predict the long-term risk of healthy men developing and dying from prostate cancer. Both could lead to more efficient and cost-effective screening for prostate cancer, with reductions in over-diagnosis and unnecessary treatment.

According to European Cancer Observatory statistics, over 70,000 men die from prostate cancer in the EU every year. Prostate cancer and benign enlargement of the prostate gland, known as benign prostatic hyperplasia, share common features. Growth of the gland is dependent on hormone levels in both conditions and both respond to anti-androgen treatment, but until now benign prostatic hyperplasia has not been considered a precursor to the development of a tumour.

Researchers investigated the association between the two conditions by examining data from five national registries, on a total of 3,009,258 Danish men.

The sample included 53,315 diagnoses of prostate cancer and 25,459 cases of death due to prostate cancer. Clinical benign prostatic hyperplasia was determined by records of hospitalisation (187,591 men) and/or operations for the condition (77,698 men) between 1980 and 2006, and the use of certain drugs indicated for the condition between 1995 and 2006 (143,365 men and 47,465 men respectively for the two treatments). The reference group was men without benign prostate hyperplasia.

Over 27 years, the study found that clinical benign prostate hyperplasia was associated with a two to three-fold increased risk of men developing prostate can
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Contact: Saffina Rana
saffina.rana@europe.com
ECCO-the European CanCer Organisation
Source:Eurekalert

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