Navigation Links
2 microRNAs promote spread of tumor cells
Date:1/28/2008

(Philadelphia) The more scientists learn about microRNAs short strands of RNA that can interfere with normal gene activity the more obvious it becomes how closely they are associated with cancer. In a new study, scientists at The Wistar Institute and their colleagues have identified two microRNAs (miRNAs) that promote tumors deadly spread, or metastasis. One of the miRNAs may provide an early warning of metastatic breast cancer and the need for aggressive treatment.

By blocking the translation of tumor suppressor genes, miRNAs have been shown to facilitate the development of many types of cancer. In a study that will be published February 1 in Nature Cell Biology and is available online, the researchers describe how two miRNAs transformed non-invasive human breast cancer cells into cells that rapidly metastasized in cell cultures and laboratory mice.

Of the 450 miRNAs we tested, we found two, miR-373 and miR-520c, that induced cell migration in MCF-7 cells a line of human breast cancer cells that normally does not metastasize, says Qihong Huang, M.D., Ph.D., an assistant professor in Wistars Molecular and Cellular Oncogenesis Program and lead author and co-corresponding author on the study.

In 2006, miR-373 was identified as a possible oncogene a modified gene that causes cancer in testicular cancer. According to Huang, miR-520c is a new miRNA whose function has not been known until now.

Our most surprising finding is that miR-373 and isoforms of miR-520 are part of the same family, Huang says. Their seed sequences, or first eight nucleotides, are all very similar. It suggests this family of miRNAs could target similar genes and have important biological and pathological functions in cancer development and metastasis.

Another intriguing characteristic of these two miRNAs is that they are not found in normal adult cells only in tumor cells. They are not in normal testis, but are expressed in testicular cancer,
'/>"/>

Contact: Abbey J. Porter
aporter@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. MicroRNAs may be key to HIVs ability to hide, evade drugs, Jefferson scientists find
2. Gentiva(R) Health Services Promotes Boelsen to Senior Vice President, CareCentrix(R)
3. China Nepstar Chain Drugstore Launches Charitable Initiative to Promote Awareness of Low-income Working Womens Health Issues
4. Hormonal dietary supplements might promote prostate cancer progression
5. The First Annual LOVE L.A. Show Promotes Sensuality, Relationships and Sexual Education
6. Photo: MultiVu Promotes George DeTorres to Divisional Vice President for the MultiVu Healthcare Team
7. A healthy smile may promote a healthy heart
8. Isolagen Inc. Promotes Declan Daly to Chief Executive Officer (CEO)
9. Some Immature Brain Cells May Promote Tumors
10. Therap Services Promotes Allison Dudo to Assistant Director of Training
11. FOXO factor promotes survival of oxygen-deprived cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... (HealthDay News) -- Present-day Europeans are the descendants ... according to a new study. Previous ... and early European farmers. But, a new genetic ... also the descendants of Ancient North Eurasians. Nearly ... third ancestral group, researchers from Harvard Medical School ...
(Date:9/17/2014)... 2014 (HealthDay News) -- Managing diabetes, quitting smoking, controlling ... can reduce the risk for dementia -- even late ... World Alzheimer Report 2014, commissioned by Alzheimer,s Disease International, ... by 50 percent. The study noted that obesity and ... as well as high blood pressure. The ...
(Date:9/17/2014)... Thompson HealthDay Reporter ... dieters who turn to artificial sweeteners to soothe their ... a new Israeli study suggests. Artificial sweeteners can ... calories, researchers found in human and mouse studies. ... the bacteria residing in the intestines in ways that ...
(Date:9/17/2014)... Mathematics might be able to reduce the need ... to the autoimmune disease lupus. , In a new ... the progression from nephritis kidney inflammation to ... cannot reverse. A kidney biopsy is the only existing ... and its extent. , The model could also be ...
(Date:9/17/2014)... Research has shown that most 18-month-olds learn an ... however, little is known about how children process information ... preschool years. In a new study, a University of ... as they age, and a limit exists as to ... findings could help parents enhance their children,s vocabularies and ...
Breaking Medicine News(10 mins):Health News:Europeans Are Descendants of at Least 3 Ancient Human Groups: Study 2Health News:Europeans Are Descendants of at Least 3 Ancient Human Groups: Study 3Health News:Healthy Lifestyle Changes Linked to Reduced Risk for Dementia 2Health News:Healthy Lifestyle Changes Linked to Reduced Risk for Dementia 3Health News:Artificial Sweeteners May Raise Blood Sugar Levels: Study 2Health News:Artificial Sweeteners May Raise Blood Sugar Levels: Study 3Health News:Math model designed to replace invasive kidney biopsy for lupus patients 2Health News:Babies learn words differently as they age, researcher finds 2
... an effective vaccine against recurrent kidney cancers.// Kidney cancer ... causes about 12,000 deaths in the United States every ... 50s and 60s. Standard treatment involves removal of all ... however, kidney cancer does not respond well to subsequent ...
... shown that a chemotherapy regimen combining vinorelbine (Navelbine) and ... the treatment of hormone-refractory prostate cancer . Specialists say ... in their disease. , However researchers added ... regimen is planned. From a group of 66 patients ...
... Breast cancer survivors can now get up and ... // older women, reported higher body esteem and ... a new study. ,Researchers compared 40 ... sedentary women, all early-stage breast cancer survivors. Regular ...
... has shown that there may be a link of type ... blood has high amounts of iron.// ,In this ... with no history of diabetes, cardiovascular disease or cancer. 700 ... iron concentration of 109 nanograms/milliliter manifested with diabetes whereas ...
... placing a soft plastic tube or catheter into the ... Patients must undergo training for two weeks and ... from the comfort of their home. Hemodialysis patients can ... attached to a blood-cleaning machine at a dialysis center. ...
... replacement therapy among breast cancer survivors has been // stopped ... or new cancers. ,Swedish researchers embarked on the study ... therefore subject to the same menopausal symptoms as other women. ... five years. After the initial 345 women in the study ...
Cached Medicine News:Health News:A Combination Of Drugs Effective In The Treatment Of Hormone-Refractory Prostate Cancer 2
(Date:9/17/2014)... , Sept. 17, 2014 The ... the last decade due to the recession, ... and technological advancements. This BCC Research report ... segments of the ambulance and emergency medical ... blood and hemorrhage control devices, equipment used ...
(Date:9/17/2014)... 2014  Decision Resources Group finds that ... for biologic therapy, only a proportion of ... cite patients, discomfort with biological therapy as ... followed by cost-related issues and payer restrictions. ... Janssen Biotech,s Remicade and AbbVie,s Humira are ...
(Date:9/17/2014)... SAN JOSE, Calif. , Sept. 17, 2014 /PRNewswire-iReach/ -- ... laureate of The Tech Awards 2014, one of 10 ... and spark global change. The Tech Awards, a signature program ... Materials, Inc., selected Gradian as one of two laureates in ... http://photos.prnewswire.com/prnh/20140917/146680 Gradian equips hospitals around the ...
Breaking Medicine Technology:Ambulance and Emergency Equipment: Global Markets 2Ambulance and Emergency Equipment: Global Markets 3Ambulance and Emergency Equipment: Global Markets 4The Majority of Surveyed Gastroenterologists Agree that Biologics Should be Prescribed to More Patients in the Crohn's Disease and Ulcerative Colitis Treatment Paradigm 2The Majority of Surveyed Gastroenterologists Agree that Biologics Should be Prescribed to More Patients in the Crohn's Disease and Ulcerative Colitis Treatment Paradigm 3Gradian Health Systems Named A 2014 Laureate of The Tech Awards 2Gradian Health Systems Named A 2014 Laureate of The Tech Awards 3
Assetrac allows identification, location, and protection of your assets....
... AgileTrac Surgical Services is a Web-based and ... track, manage, and measure patient flow and ... from admission to discharge. AgileTrac collects patient ... care delays your patient might experience. This ...
... The RoamAlert ECO system provides ... several doors. Each exit is ... When a resident wearing a ... the door will lock; or ...
... Awarix provides an enterprise visibility ... throughput, improve caregiver effectiveness, and increase ... edge RFID location systems and geospatial ... systems to create a real time ...
Medicine Products: