Navigation Links
2 human proteins found to affect how 'jumping gene' gets around
Date:11/21/2013

Using a new method to catch elusive "jumping genes" in the act, researchers have found two human proteins that are used by one type of DNA to replicate itself and move from place to place. The discovery, described in the Nov. 21 issue of Cell, breaks new ground, they say, in understanding the arms race between a jumping gene driven to colonize new areas of the human genome and cells working to limit the risk posed by such volatile bits of DNA.

Jumping genes, more formally known as transposons or transposable elements, are DNA segments with the blueprints for proteins that help to either copy the segment or remove it, then insert it into a new place in the genome. Human genomes are littered with the remnants of ancient jumping genes, but because cells have an interest in limiting such trespasses, they have evolved ways to regulate them. Most jumping genes have mutated and can no longer move, but these "rusting hulks" are still passed down from generation to generation.

One exception is a jumping gene called L1, which has been so successful that copies of it make up about 20 percent of human DNA. While many of these copies are now mutated and dormant, others are still active and thus the subject of much interest from geneticists.

"Human cells have evolved ways of limiting jumping genes' activity, since the more frequently they move, the more likely they are to disrupt an important gene and cause serious damage," says Lixin Dai, Ph.D., a postdoctoral associate at the Johns Hopkins Institute for Basic Biomedical Sciences, who led the study. To find out more about how cells control L1 and what tricks the jumping gene uses to get around these defenses, Dai and others in the laboratory of Jef Boeke, Ph.D., first induced lab-grown human cells to make large amounts of the proteins for which L1 contains the blueprints. As expected, the two types of L1 protein joined with human proteins and genetic material called RNA to form so-call
'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Diet Doc Hormone Diets & Weight Loss Plans Improve Human Heart Health With Prescription Hormone Diet Plans That Help Dieters Lose Weight Fast
2. What composes the human heart? U of T researchers crunch the numbers
3. Predicting human body height from DNA
4. The human health costs of losing natural systems: Quantifying Earths worth to public health
5. China Human Vaccine Industry Report, 2012-2015
6. Mahendra Trivedi Announces the New Master During the Historical Event “Transforming Humanity”
7. NHS Human Services Foundation to Host 10th Annual Leading the Way Awards Gala
8. Geranylgeraniol suppresses the viability of human prostate cancer cells and HMG CoA reductase
9. Tel Aviv University part of team launching global Human Brain Project
10. Western University of Health Sciences’ Gala Fundraiser Emphasizes Humanism and Caring
11. Animal, human health benefits anticipated from universitys premier biomedical instrument
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
2 human proteins found to affect how 'jumping gene' gets around
(Date:12/25/2014)... (PRWEB) December 25, 2014 Product liability ... ASR hip recall ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move ... to an Order issued in the U.S. District Court, ... will convene an open conference on January 7, 2015, ... States Courthouse in West Palm Beach, Florida. The Conference ...
(Date:12/25/2014)... Recently, iFitDress.com, the popular online supplier of wedding ... new selection of black one-shoulder cocktail dresses . In ... are available at discounted prices, up to 70% off. ... for three weeks only. You know, we have thousands of ... in our new items can visit our website for more ...
(Date:12/25/2014)... December 25, 2014 The short film “Color ... created in honor of a true 9/11 hero, Welles Remy ... festivals including the 24 hours of Nuremberg International Short Film ... , Actress, screenwriter and director Luciana Lagana ... film together with her husband, Gregory Graham - ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
(Date:12/25/2014)... When head lice hits a home or school, parents and ... of it while keeping it from taking over the house ... solution right in their neighborhood: Lice Troopers . Expanding ... spectrum head lice screening and treatment services to families and ... Brickell, Coconut Grove, Kendall, Pinecrest and South Miami. , The ...
Breaking Medicine News(10 mins):Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2
... Tyco,International Ltd. (NYSE: TYC , BSX: TYC) announced ... the company,s quarterly dividend to 15,cents per share for ... represents a 36% increase over the quarterly dividend of,approximately ... to,pay following the separation of Tyco into three public ...
... ViroPharma Incorporated,(Nasdaq: VPHM ) today announced that ... officer of ViroPharma, will present,at the Maxim Group ... on,Thursday, September 20, 2007. The conference is being ... ViroPharma,s presentation will be webcast live for investors ...
... sex, research shows , , THURSDAY, Sept. 13 (HealthDay News) -- ... their number of sexual partners, U.S. researchers report. , More ... States in 2005 were among gay men, a team at ... as one in five gay men living in cities may ...
... Dana-Farber Cancer Institute have shown that several, rather ... in many brain tumors and other solid tumors, ... switch-blocking drug often yields disappointing results. , The ... trials that combine three or more such targeted ...
... Mayo Clinic,s,Multidisciplinary Simulation Center is now one ... States to be accredited by,the American College of ... offer and advance medical education that will improve ... to keep pace with,rapidly changing technologies. Mayo,s ...
... at Interlachen Country Club ... suicide prevention., MINNEAPOLIS, Sept. 13 Suicide Awareness,Voices ... 2007) this week with a special appearance at the ... H. Humphrey Metrodome in,Minneapolis. SAVE is a national, non-profit ...
Cached Medicine News:Health News:Tyco International Increases Quarterly Dividend 36 Percent to 15 Cents per Share; Initiates New $1 Billion Share Repurchase Program 2Health News:Number of Partners Doesn't Explain Gay HIV Rate 2Health News:Number of Partners Doesn't Explain Gay HIV Rate 3Health News:Study suggests brain tumors need treatment with multiple 'targeted' drugs 2Health News:Study suggests brain tumors need treatment with multiple 'targeted' drugs 3Health News:Mayo Clinic Multidisciplinary Simulation Center Receives Distinction as an ACS-Accredited Education Institute 2Health News:Mayo Clinic Multidisciplinary Simulation Center Receives Distinction as an ACS-Accredited Education Institute 3Health News:SAVE Recognizes National Suicide Prevention Week 2
(Date:12/24/2014)... ALEXANDRIA, Va. , Dec. 23, 2014 /PRNewswire-USNewswire/ ... stringent diastolic blood pressure target for people with ... either moderate or high doses of statins, in ... risk management enacted by the American College of ... recommendations are reflected in the most recent changes ...
(Date:12/24/2014)... and RALEIGH, N.C. , Dec. ... Endo International plc (NASDAQ: ENDP ) (TSX: ... BDSI ) announced today that they have submitted a ... to the U.S. Food and Drug Administration (FDA).  Buprenorphine ... of pain severe enough to require daily, around-the-clock, long-term ...
(Date:12/22/2014)... Dec. 22, 2014 NxStage Medical, Inc. (NASDAQ: ... innovative dialysis products, announced today that the U.S. ... System One™ to perform hemodialysis overnight while the ... nocturnal hemodialysis. NxStage,s® System One is the first ... for this indication. Home nocturnal ...
Breaking Medicine Technology:New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3
... Sequenom, Inc. (Nasdaq: SQNM ) today announced that ... U.S. District Court for the Southern District of California ... in the class action securities lawsuits consolidated under the caption ... No. 3:09-cv-00921 LAB-WMC.  A copy of the stipulation of settlement is ...
... MOUNTAIN VIEW, Calif. , May 5 Alexza Pharmaceuticals, Inc. (Nasdaq: ... King will present during The Ninth Annual JMP Securities Research Conference.  The ... 8:00 am PT .  The presentation will be webcast from the Ritz Carlton ... , , ...
Cached Medicine Technology:Sequenom Announces Final Approval of Settlement in Class Action Securities Lawsuit 2Alexza Pharmaceuticals to Present at The Ninth Annual JMP Securities Research Conference 2Alexza Pharmaceuticals to Present at The Ninth Annual JMP Securities Research Conference 3
... The IEC CL40 and FL40 ... power, safety and versatility to increase ... with a broad array of rotors ... processing and microplate applications, the IEC ...
... Thermos IEC CL31 Multispeed Series ... in a quiet, compact, 1.2 liter ... of rotors and accessories and high-speed ... offers virtually everything you need to ...
Blood pressure monitor will measure blood pressures and pulse rates accurately and reliably....
When you use the optional REAL-Time Continuous Glucose Monitoring Kit with your insulin pump, you will have access to REAL-Time glucose readings, safety alarms, and glucose trend data around the cloc...
Medicine Products: