Navigation Links
2 genetic deletions in human genome linked to the development of aggressive prostate cancer
Date:4/9/2012

y of cancer cells to grow and to invade.

Both of these variants are small deletions in DNA that lead to over-expression of genes, Dr. Demichelis says. She and her colleagues found that one gene that is over-expressed due to the variant deletion is MGAT4C, which leads to the ability of cells to grow and migrate. "A man with the variant is four times more likely to develop prostate cancer if he inherited this variant than if he did not," Dr. Demichelis says. "Interestingly, MGAT4C was found to be significantly over-expressed in metastatic versus localized prostate cancer," she adds.

The role of the other genetic variant, located in the "junk" region of the human genome, is not yet known, but the researchers believe it activates a cascade of other genes. They calculated a man is three times more likely to develop prostate cancer if he has inherited this variant.

The investigators calculated these two newly identified variants occur at a frequency of between 1.5-3 percent of the overall population, but are found at a significantly higher percentage in men diagnosed with aggressive prostate cancer. "For the gene coding variant, MGAT4C, we were able to analyze metastatic human samples where we observed that the high-risk gene is abundantly present," says Dr. Demichelis.

Now researchers are looking for other variants they hope to be able to build into a comprehensive DNA test to be used as a diagnostic tool to help clinicians identify men whose prostate cancer will likely progress to advanced stages. "We could also potentially use such a DNA test for chemoprevention if risk of developing aggressive prostate cancer is deemed to be high," says Dr. Demichelis. "This is the start of a new strategy. It would not replace PSA, but would identify other risk factors."

"In this new area of research, we are starting to appreciate that the differences in inherited genomic variants account not only for why we look different or respond in var
'/>"/>

Contact: Lauren Woods
law2014@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. IntegraGen launches ARISk test, a genetic screening tool for autism in high-risk children
2. Genetic causes found in nearly 1 in 5 patients with dilated cardiomyopathy heart failure
3. Research uncovers genetic marker that could help control, eliminate PRRS virus
4. PCP genetic pathway acts as stop sign for cell growth
5. Genetic profiling can help doctors more accurately predict prognosis and guide treatment decisions for leukemia patients
6. From Refrigerator Mothers to untangling the genetic roots of autism
7. Genetic Tweak Helps Mice Avoid Cancer, Obesity: Study
8. Researchers find possible genetic keys to surviving epithelial ovarian cancer
9. Genetic variants affect arsenic metabolism and toxicity in Bangladesh
10. Stealth properties of cancer-causing genetic mutations identified
11. ROCK off: Study establishes molecular link between genetic defect and heart malformation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015 Juvent Sports ( http://www.juventsports.com ) ... PGA Merchandise Show to bestow a Juvent Sports Achievement ... golfer, Arlene McKitrick. The award commemorated and congratulated McKitrick ... win. She won her first amateur tournament in 1979 ...
(Date:1/22/2015)... January 22, 2015 Autocarinsurancebest.com has released a ... a commercial auto insurance policy . , Auto insurance ... vehicles. It is no longer necessary to call an agent ... now available online on a single website: http://autocarinsurancebest.com/ . ...
(Date:1/22/2015)... Joan Lunden, award-winning American journalist, beloved television host, ... 32nd Annual Miami Breast Cancer Conference planned and ... , shares that “a fast-growing, virulent” cancer in her ... not followed up her clean mammogram with an ultrasound. ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne ... highest annual revenues in the past three years. Today, the ... dresses. , According to the sales manager of the company, ... them in 2015. This point can be reflected on the ...
(Date:1/22/2015)... 2015 Payday lending practices in four ... cause financial distress to the states that permit them, ... University’s Center on Race and Wealth. , While they ... payday loans at the same time substantially depress economic ...
Breaking Medicine News(10 mins):Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2
... April 21 Seven years after becoming the Midwest,s first ... The Chicago School of Professional Psychology is expanding ... individuals seeking to advance their career in the law and ... will begin this fall at the school,s Chicago Campus at ...
... to invite disease, study finds , , TUESDAY, April ... well done, but eating burned or charred meat may ... suggests. , Researchers used data on the meat intake, ... participants taking part in the Prostate, Lung, Colorectal and ...
... Thinking your memory will get worse as you get older ... State University have found that senior citizens who think older ... much worse than seniors who do not buy in to ... study published earlier this month, psychology professor Dr. Tom Hess ...
... Information Systems, Inc., which through its wholly-owned operating ... Personal Health Records ("PHRs") ( www.mymedicalrecords.com ... ( www.myesafedepositbox.com ), announced today that ... MMRF effective upon market opening on Wednesday, April ...
... 21 New research with actionable insights on critical ... now available in the Best Practice Database, an online ... Practices, LLC.To review key topics in these studies, go ... the two new studies at this address: ...
... break even after $230 million of losses in past 3 ... 21 After three years of operating losses totaling more ... of less than one-half of 1 percent of revenue ... figures released today by the Minnesota Council of Health Plans. ...
Cached Medicine News:Health News:The Chicago School of Professional Psychology Announces Nation's First Psy.D. Program in Clinical Forensic Psychology 2Health News:The Chicago School of Professional Psychology Announces Nation's First Psy.D. Program in Clinical Forensic Psychology 3Health News:Charring Meat May Boost Risk of Pancreatic Cancer 2Health News:Think memory worsens with age? Then yours probably will 2Health News:MMR Information Systems, Inc. Announces Ticker Symbol Change 2Health News:MMR Information Systems, Inc. Announces Ticker Symbol Change 3Health News:Best Practice Database Adds Research Highlighting Effective Data Gathering Approaches for Competitive Intelligence and Successful Activities for Gaining Maximum Payer Access and Insights 2Health News:Minnesota Health Plans Reserves, Investment Income Down 2Health News:Minnesota Health Plans Reserves, Investment Income Down 3
(Date:1/23/2015)... , Jan. 23, 2015 Gem Pharmaceuticals announced today ... been enrolled into the Company,s Phase 2 clinical trial. ... of Gem,s lead compound, GPX-150 (an investigational medication), in ... metastatic disease. Logo - http://photos.prnewswire.com/prnh/20150123/170966LOGO ...
(Date:1/22/2015)... Inc. (NASDAQ: UPI ), a medical device company ... treat voiding dysfunctions, today reported financial results for the ... Global revenue for the Company,s Urgent ®  PC Neuromodulation ... revenue record, as compared to $3.9 million in the ...
(Date:1/22/2015)... DIEGO , Jan. 22, 2015  Profil Institute for ... on diabetes and obesity, announced today a new textbook,  ... Development,  published by Springer, a leading global scientific publisher. ... analyze and illustrate techniques for use in early phase ...
Breaking Medicine Technology:Gem Pharmaceuticals Announces Enrollment of Initial Patients in its Phase 2 Clinical Trial to Assess the Efficacy and Safety of GPX-150 in Sarcoma Patients 2Uroplasty Reports Record Revenue in Fiscal Third Quarter 2Uroplasty Reports Record Revenue in Fiscal Third Quarter 3Uroplasty Reports Record Revenue in Fiscal Third Quarter 4Uroplasty Reports Record Revenue in Fiscal Third Quarter 5Uroplasty Reports Record Revenue in Fiscal Third Quarter 6Uroplasty Reports Record Revenue in Fiscal Third Quarter 7Uroplasty Reports Record Revenue in Fiscal Third Quarter 8Uroplasty Reports Record Revenue in Fiscal Third Quarter 9Uroplasty Reports Record Revenue in Fiscal Third Quarter 10Uroplasty Reports Record Revenue in Fiscal Third Quarter 11Uroplasty Reports Record Revenue in Fiscal Third Quarter 12Uroplasty Reports Record Revenue in Fiscal Third Quarter 13Uroplasty Reports Record Revenue in Fiscal Third Quarter 14Uroplasty Reports Record Revenue in Fiscal Third Quarter 15Uroplasty Reports Record Revenue in Fiscal Third Quarter 16Uroplasty Reports Record Revenue in Fiscal Third Quarter 17Uroplasty Reports Record Revenue in Fiscal Third Quarter 18New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 2New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 3
... familiar and proven features of the Concept 400, ... patented gas mixing system.The gas mixing module provides ... 0.1% increments), carbon dioxide (0% - 12% in ... 1% increments) components of the mix with integral ...
Providing a perfect combination of capacity, speed and innovation, the Concept 400 delivers simple sophistication and new levels of comfort and convenience....
The airlock allows anaerobic entry of large flasks, vessels, and up to 90 plates at a time....
... Even without an electrical power supply, MERKUR ... are supported by a gas spring for ease ... is equipped with a foot pedal hydraulic system. ... used anywhere and anytime in a highly mobile ...
Medicine Products: