Navigation Links
2 genetic deletions in human genome linked to the development of aggressive prostate cancer
Date:4/9/2012

r Computational Biomedicine at Weill Cornell Medical College.

The two genetic variants identified by the research team are not the only cause of aggressive prostate cancer, Dr. Demichelis says. "These variants likely collaborate with other factors early in a man's life leading to development of prostate cancer."

Prostate cancer affects one in six men during their lifetime, and family history is the strongest risk factor for prostate cancer. Because of the inheritable nature of the disease, for the study Weill Cornell researchers hunted to find DNA that is either significantly deleted or duplicated in the genome of patients with prostate cancer to compare it to men without the disease.

In this collaboration between Weill Cornell Medical College, the Brigham and Women's Hospital and Innsbruck University Hospital, researchers examined blood samples from a population of men from the Tyrol Early Prostate Cancer Detection Program in Austria. Since 1993, this program has been aggressively screening men, age 45-75, who live in the Tyrol region with prostate specific antigen (PSA) in order to detect prostate cancer as early as possible. The population includes men who developed prostate cancer as well as men with elevated PSA who have no prostate cancer based on a biopsy. In addition, researchers looked at the germline variation in these patients to see if there is a risk factor as to why some men with elevated PSA have prostate cancer and some men do not.

Molecular studies were performed in the U.S. on more than 1900 blood samples from Tyrolean men (867 unrelated cancer patients and 1,036 controls). Researchers discovered two CNVs that were significantly different between Tyrolean individuals with aggressive prostate cancer and those without cancer, and then reproduced that finding in another group of 800 U.S. patients. The researchers then tested the effect of the two variants in laboratory cells and discovered they increase the abilit
'/>"/>

Contact: Lauren Woods
law2014@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. IntegraGen launches ARISk test, a genetic screening tool for autism in high-risk children
2. Genetic causes found in nearly 1 in 5 patients with dilated cardiomyopathy heart failure
3. Research uncovers genetic marker that could help control, eliminate PRRS virus
4. PCP genetic pathway acts as stop sign for cell growth
5. Genetic profiling can help doctors more accurately predict prognosis and guide treatment decisions for leukemia patients
6. From Refrigerator Mothers to untangling the genetic roots of autism
7. Genetic Tweak Helps Mice Avoid Cancer, Obesity: Study
8. Researchers find possible genetic keys to surviving epithelial ovarian cancer
9. Genetic variants affect arsenic metabolism and toxicity in Bangladesh
10. Stealth properties of cancer-causing genetic mutations identified
11. ROCK off: Study establishes molecular link between genetic defect and heart malformation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... 2014 Market Research Report ... 2009-2019 is a professional and in-depth market ... industry. The report firstly reviews the basic ... application and manufacturing technology. The report then ... Molecular Diagnostics listing their product specification, capacity, ...
(Date:10/25/2014)... 25, 2014 Limbkeepers® announced today that ... Innovations with Ed Begley Jr, airing 1st QTR 2015 ... In this episode, Innovations will focus on Limbkeepers® non ... fragile, thinning skin on arms, hands, and legs from ... these versatile products, which help reduce injuries, allow for ...
(Date:10/25/2014)... Oct. 23, 2014 (HealthDay News) -- A large influx ... Africa is to avoid tens of thousands of deaths ... University researchers predict. Using a specially designed ... of the outbreak in just one densely populated county ... capital city of Monrovia. The researchers said that ...
(Date:10/22/2014)... On Saturday, October 25, 2014, the Brownsville Community Health Center ... fair ¡Vive tu vida! Get Up! Get Moving!®. The event ... health and wellness for people of all ages and all ... public, will be held at Dean Porter Park, 501 E. ... , “¡Vive tu Vida! Get Up! Get Moving!® helps ...
(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. 21, ... Ebola cases in Dallas. But, mental health specialists say overblown ... President Barack Obama on Friday appointed an Ebola "czar" to ... two Dallas nurses who cared for a Liberian man who ... But the U.S. cases are miniscule in the context ...
Breaking Medicine News(10 mins):Health News:Global and China Molecular Diagnostics Industry Analysis to 2019 is Now Available at RnRMarketResearch.com 2Health News:Global and China Molecular Diagnostics Industry Analysis to 2019 is Now Available at RnRMarketResearch.com 3Health News:Global and China Molecular Diagnostics Industry Analysis to 2019 is Now Available at RnRMarketResearch.com 4Health News:Upcoming Episode of Innovations with Ed Begley, Jr. to Feature Limbkeepers® 2Health News:Experts Predict 'Catastrophic' Ebola Epidemic in West Africa if Aid Delayed 2Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 2Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 3Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 4Health News:Ebola Anxiety: A Bigger Threat Now Than the Virus Itself 2Health News:Ebola Anxiety: A Bigger Threat Now Than the Virus Itself 3
... comparison study finds chlorthalidone most likely to prevent ... News) -- Tried-and-true diuretics maintain their status as ... women with high blood pressure, new research concludes. ... treatments -- a calcium channel blocker, an ACE ...
... , Government Also Files Suit Against New York Hospital ... WASHINGTON, Nov. 18 The United States has entered into ... motion to intervene in a lawsuit against a New York ... Department announced today. , The United States settled ...
... Sinai School of Medicine set out to address a ... do dietary restrictionand the reverse, overconsumptionproduce protective effects against ... two-part study led by Charles Mobbs, PhD, Professor of ... Sinai School of Medicine, published in the November 17 ...
... ... and spa therapy for 30 years, has received the distinguished School of Excellence Award ... only ACCSC-accredited school in Massachusetts to receive this 2008-2009 Award. , ... Woburn, MA, November 18, 2009-- ...
... ... The Adaptive Business Leaders (ABL) Organization is asking for nominations for ... 12th Annual Innovations in Healthcare(SM) Awards Event, on April 28, 2010, in ... their value-driven approaches to solving some of the toughest problems facing healthcare ...
... MINEOLA, N.Y., Nov. 18 The United States Preventive ... a woman should be getting a mammography. The Maurer ... an official statement regarding her research and beliefs on ... Yesterday, The United States Preventive Services Task Force (USPSTF) ...
Cached Medicine News:Health News:Diuretics Still Best Treatment for High Blood Pressure 2Health News:New Jersey Hospital to Pay $3 Million to Resolve Allegations of Medicare Fraud 2Health News:Scientists find molecular trigger that helps prevent aging and disease 2Health News:Scientists find molecular trigger that helps prevent aging and disease 3Health News:ACCSC Grants Catherine Hinds Institute of Esthetics a Distinguished School of Excellence Award Award Recognizes High-Level Achievements of Students 2Health News:ACCSC Grants Catherine Hinds Institute of Esthetics a Distinguished School of Excellence Award Award Recognizes High-Level Achievements of Students 3Health News:Nominate Your Favorite Innovative Healthcare Company for the 2010 ABBY Awards 2Health News:Nominate Your Favorite Innovative Healthcare Company for the 2010 ABBY Awards 3Health News:Nominate Your Favorite Innovative Healthcare Company for the 2010 ABBY Awards 4Health News:Maurer Foundation for Breast Health Education Statement on USPSTF Guidelines for Mammography 2
(Date:10/25/2014)... Oct. 24, 2014 In conjunction with DURECT ... financial results press release, you are invited to listen ... over the internet on Monday, November 3, 2014 at ... A live audio webcast of the presentation will ... and clicking "Investor Relations."  If you are unable ...
(Date:10/25/2014)... CHAPEL HILL, N.C. , Oct. 24, 2014 ... virtual teams can provide a company access to ... about emerging markets, and round-the clock business hours ... requires overcoming difficult hurdles. According ... global team disappointments, such as seeing a project ...
(Date:10/22/2014)... Oct. 22, 2014  Quest Diagnostics (NYSE: ... services, today announced that its Board of Directors has ... director, effective December 1, 2014. Including Dr. Leiden, the ... the Chairman, President and CEO of Vertex Pharmaceuticals.   ... and commercial experience in the pharmaceutical and biotechnology industries ...
Breaking Medicine Technology:DURECT Corporation Invites You to Join its Third Quarter 2014 Earnings Conference Call 2Work Around the Clock: Successfully Building & Managing Global Virtual Teams 2Quest Diagnostics Adds Jeffrey M. Leiden, M.D., Ph.D., to Board of Directors 2Quest Diagnostics Adds Jeffrey M. Leiden, M.D., Ph.D., to Board of Directors 3
... 25, 2011 Savient Pharmaceuticals, Inc. (Nasdaq: SVNT ... John H. Johnson as Chief Executive Officer, effective January 31, ... Savient,s board of directors. Mr. Johnson brings significant ... a Senior Vice President of Eli Lilly and Company and ...
... recently launched eCS Inpatient EHR V1.2 (eCS), the first ... medium hospitals. eCS,s uniqueness is the tight linkage of ... a single web-based software solution. The solution is offered ... simplified deployment. "eCS is an affordable solution ...
Cached Medicine Technology:Savient Pharmaceuticals Names John H. Johnson Chief Executive Officer 2Savient Pharmaceuticals Names John H. Johnson Chief Executive Officer 3Savient Pharmaceuticals Names John H. Johnson Chief Executive Officer 4eCareSoft Launches Comprehensive EHR for Small & Medium Hospitals 2
View Mex-3 is designed for out-patient surgery, hospital rounds and house calls....
Headlight module is mounted on UltraLite Plus headband or sweatband....
It is a magnifying headlight perfect for all applications and procedures where clear magnification and a natural white light increase accuracy and productivity....
It is a magnifying headlight perfect for all applications and procedures where clear magnification and a natural white light increase accuracy and productivity....
Medicine Products: