Navigation Links
2 genetic deletions in human genome linked to the development of aggressive prostate cancer
Date:4/9/2012

NEW YORK (April 9, 2012 ) -- An international research team led by Weill Cornell Medical College investigators have discovered two inherited-genetic deletions in the human genome linked to development of aggressive prostate cancer. The findings, published online today in the Proceedings of the National Academy of Sciences (PNAS), indicate a man's risk of developing prostate cancer either triples or quadruples, depending on the genetic variant they inherit.

In the study, one genetic deletion is shown to affect the functioning of a known gene, while the other, found in a non-coding area of the genome once considered to be "junk DNA," seems to be regulating a cascade of genes. According to the lead co-authors, the study is potentially groundbreaking because it demonstrates that so-called copy number variations (CNVs) in either protein coding or non-coding areas of the human genome play a significant role in the development of cancer in general, and in aggressive prostate cancer, specifically.

"We used to think that only genes that made proteins were responsible for disease, but this study shows us that there is inherited information in the non-coding areas of the genome that appear to play a strong role in development of cancer," says study co-author, Dr. Mark A. Rubin, the Homer T. Hirst Professor of Oncology in Pathology at Weill Cornell Medical College. Other researchers have linked CNVs to Alzheimer's and Parkinson's disease, mental retardation, autism, schizophrenia and neuroblastoma, a type of brain cancer. "This study suggests there are other cancers that might be associated with CNVs," says Dr. Rubin. "It's an exciting new field of research."

"The study shows that copy number variations matter in cancer," says co-lead investigator, Dr. Francesca Demichelis, who is now an Assistant Professor at the Center of Integrative Biology at the University of Trento in Italy and an Adjunct Assistant Professor in the Institute fo
'/>"/>

Contact: Lauren Woods
law2014@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. IntegraGen launches ARISk test, a genetic screening tool for autism in high-risk children
2. Genetic causes found in nearly 1 in 5 patients with dilated cardiomyopathy heart failure
3. Research uncovers genetic marker that could help control, eliminate PRRS virus
4. PCP genetic pathway acts as stop sign for cell growth
5. Genetic profiling can help doctors more accurately predict prognosis and guide treatment decisions for leukemia patients
6. From Refrigerator Mothers to untangling the genetic roots of autism
7. Genetic Tweak Helps Mice Avoid Cancer, Obesity: Study
8. Researchers find possible genetic keys to surviving epithelial ovarian cancer
9. Genetic variants affect arsenic metabolism and toxicity in Bangladesh
10. Stealth properties of cancer-causing genetic mutations identified
11. ROCK off: Study establishes molecular link between genetic defect and heart malformation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... (PRWEB) August 22, 2014 Japantown Dental ... a new teeth whitening technique. Air polishing is a ... appointments. , Dark teeth can be caused by a ... external stains and internal stains. External stains include coffee, ... be caused by certain medications, such as tetracycline, and ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 The regional ... Toyota Indiana is on the grow again. ... jobs by summer 2016 to boost production of the ... bring Toyota Indiana’s overall investment to $4 billion. This ... America while providing additional flexibility to adjust its product ...
(Date:8/22/2014)... The LSU Health New Orleans School of Nursing ... grant to increase access to advanced nursing education ... groups, as well as veterans. The Health Resources ... Health and Human Services awarded the two-year grant. ... grant,s project director., The Advanced Education Nursing Traineeship ...
(Date:8/22/2014)... Lake Worth, FL (PRWEB) August 22, 2014 ... alcohol addiction treatment facility in Lantana, FL, recently ... or those just looking for information can now ... , Millennium’s new website just went live at ... to know about the facility can be found ...
(Date:8/22/2014)... Vegas, NV (PRWEB) August 22, 2014 ... that uses university-proven research to show people how they can ... lean muscle in only a matter of weeks has caught ... , “Ben Pakulski is one of the most well-known bodybuilders ... get the body he has today, that in itself is ...
Breaking Medicine News(10 mins):Health News:Japantown Dental Introduces Air Polishing 2Health News:Toyota Indiana Adding 300 Jobs to Build More Highlanders 2Health News:Millennium Treatment Group Has a New Website 2Health News:Mi40x: Review Exposes Ben Pakulski’s Guide to Packing on Lean Muscle Fast 2
... , MONDAY, April 9 (HealthDay News) -- People ... problems, such as ulcers and bleeding, and also for ... The findings highlight the need to develop new ... arthritis patients, according to the Mayo Clinic researchers. ...
... than 60 percent of breast cancer survivors report at ... diagnosis, according to a new study led by a ... University of Pennsylvania. The findings are part of a ... late effects of breast cancer treatment and creating strategies ...
... , MONDAY, April 9 (HealthDay News) -- Hispanics and ... and Medicare and Medicaid patients are less likely to receive ... says. University of Michigan School of Public Health researchers ... were 1.5 times more likely to receive antidepressants than blacks ...
... , (WASHINGTON, April 9, 2012) A novel anti-leukemia compound with ... (T-ALL), suggesting its potential to become a new highly targeted ... according to results from a study published ... of the American Society of Hematology (ASH). ...
... 262 Pages | $29.95 | ISBN13: 9780199892594) "Roberta Ness teaches how ... as its subject, Dr. Ness shows how, with a little know-how and ... selves.", ... Medicine, National Academies of Science "Great science depends on innovative ...
... in-patient rehabilitation are more likely to land back in ... poorly, show signs of depression and lack social support ... Branch (UTMB) at Galveston. Hospital readmission for older adults ... billion annually. , Among the first of such ...
Cached Medicine News:Health News:Gastro Woes Often Strike Rheumatoid Arthritis Patients 2Health News:Breast cancer patients suffer treatment-related side effects long after completing care 2Health News:Breast cancer patients suffer treatment-related side effects long after completing care 3Health News:Minorities, Medicare Recipients Less Likely to Get Antidepressants 2Health News:Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment 2Health News:Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment 3Health News:Innovation Generation 2Health News:Innovation Generation 3Health News:Predictors identified for rehospitalization among post-acute stroke patients 2Health News:Predictors identified for rehospitalization among post-acute stroke patients 3
(Date:8/22/2014)... 2014  - MediaLINC ... Today Lincor announced general availability of MediaLINC ... a range of education, entertainment and clinical content direct ... http://photos.prnewswire.com/prnh/20140822/702945) , " Lincor has ... patient engagement to bedside smart devices, " comments ...
(Date:8/22/2014)... -- Landauer, Inc. (NYSE: LDR ), a recognized ... outsourced medical physics services and high quality medical consumable ... its President and Chief Executive Officer, will be stepping ... a member of the Board of Directors, effective as ... an interim basis by Michael T. Leatherman , ...
(Date:8/22/2014)...  WaferGen Bio-systems, Inc. (NASDAQ: WGBS) today announced the ... common stock and warrants at a price of $10,000 ... to deducting underwriting discounts and commissions and offering expenses ... immediately separable and will be issued separately.  The shares ... The NASDAQ Stock Market under the ticker symbol "WGBS" ...
Breaking Medicine Technology:Lincor Unveils Next Generation TV-based Patient Engagement Solution 2Landauer, Inc. Announces Executive Management Change 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 3WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 4
... 2012   OphthaliX (OTCBB: OPLI) today reported its ... 31, 2012. OphthaliX is an advanced clinical-stage biopharmaceutical company ... ophthalmic disorders.  Our drug, CF101 (known generically as IB-MECA), ... eye syndrome; glaucoma and uveitis. We are currently: (i) ...
...  Fluke Biomedical announced today the newest addition to ... and troubleshooting tools, the SPOT Light SpO2 ... maintenance (PM) test for SpO2 patient monitor functionality, ... SpO2 functional tester ever achieved by this industry-leading ...
Cached Medicine Technology:OphthaliX Reports First Quarter 2012 Financial Results 2OphthaliX Reports First Quarter 2012 Financial Results 3Fluke Biomedical launches speedy new ProSim™ SPOT Light SpO2 Functional Tester 2
... replace the carpal scaphoid bone. The implant has ... under a shelf formed in the carpal trapezium ... the proximal hole for suture fixation. These temporarily ... period until a firm capsuloligamentous system has formed ...
... has the same anatomical configuration as the ... to provide for stability. The implant has ... use in suture fixation through the scaphoid ... while a capsuloligamentous system forms around the ...
... for four corner fusion of the capitate, ... hand. The plate is intended for use ... of function due to SLAC and SNAC ... rheumatoid arthritis. When combined with the specially ...
The 3.0 mm Cannulated Screw can be used with or without threaded washer. Uses 1.1 mm threaded or non-threaded guide wire. , ,The Threaded Washer provides a recessed internal buttress which allows the...
Medicine Products: