Navigation Links
2 gene mutations linked to most common brain cancers -- and longer survival
Date:2/18/2009

at they could not compare survival data in oligodendroglioma patients because there were too few tumors that did not carry the mutations.

"Gliomas with IDH1/IDH2 mutations clearly make up a clinically and biologically distinct subgroup of brain cancers that may benefit from targeted therapies in the future," says Parsons.

IDH1, which stands for isocitrate dehydrogenase 1, was first spotted last year in results from a genomewide scan of brain cancer mutations led by the Johns Hopkins scientists. At the time, the scientists linked mutations in the IDH1 gene to roughly 12 percent of glioblastomas (or glioblastoma multiforme), the most lethal form of glioma.

Add to this the newly discovered mutations occurring in lower grade astrocytomas and oligodendrogliomas, and Parsons estimates that 6,000 adults and children with brain cancer per year in the U.S. could be affected.

"Pathologists may find it useful to determine IDH1/IDH2 status to help identify and classify these cancers," says Parsons. He added that proper diagnosis is essential because treatments differ within types of gliomas, as well as other forms of brain cancer.

"New treatments could be designed to target the enzymatic activity that is altered by these mutations," says Victor Velculescu, M.D., Ph.D., associate professor and director of cancer genetics at the Ludwig Center at Johns Hopkins.

"The mutations appear to occur very early in the progression of these cancers, perhaps at the stem cell level," adds Bert Vogelstein, M.D., Clayton Professor and co-director of the Ludwig Center at Johns Hopkins and a Howard Hughes Medical Institute investigator.

Mutations were found by a standard technique of amplifying sections of the IDH1 and IDH2 genes through polymerase chain reaction (PCR), a process that replicates bits of DNA to levels that can be detected by sensitive computer equipment.


'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Gene Mutations May Cause Rare Neonatal Diabetes
2. Ashkenazi ovarian cancer patients with BRCA mutations live longer than those with normal gene
3. BRCA Mutations Dont Raise Breast Cancer Risk Equally
4. Genetic Mutations Boost Prostate Cancer Risk
5. Scientists explore factors contributing to DNA mutations
6. Benefit of cancer prevention surgery differs between women with BRCA1 and BRCA2 mutations
7. 2 Mutations Were Critical to Spread of 1918 Flu
8. Einstein researchers discover gene mutations linked to longer lifespans
9. Gene Mutations for Rare Heart Disease Also Found in Kids
10. Different mutations in single gene suggest Parkinsons is primarily an inherited genetic disorder
11. Second breast cancer may be greater than thought for high-risk women without BRCA mutations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2015)... York (PRWEB) April 19, 2015 New ... Multidistrict Litigation (JPML) indicate that Lipitor lawsuits ( http://www.lipitorlawsuitcenter.com/ ... in U.S. District Court, District of South Carolina. According ... cases have been filed in the proceeding on behalf ... to their use of the cholesterol-lowering statin. This represents ...
(Date:4/19/2015)... Hanover, MA (PRWEB) April 19, 2015 Family ... Bowling for Brains in Memory of Brad Baddeley ... renowned Brain Aneurysm Foundation. , Bowling for Brains is cheduled ... Bowling located 4700 Dudley Street in Lincoln, Nebraska. Participants may ... from 1:00 to 3:00pm. , The cost is only $4 ...
(Date:4/18/2015)... Carinsurancequotesinfo.com has released a new blog post explaining ... caused by a car accident. , Car insurance ... A policy can pay for car repairs and even ... carry appropriate coverage when they are driving. ... several important riders that offer extra coverage options. One ...
(Date:4/18/2015)... Review of Ophthalmology magazine and Abbot Medical ... program for cataract surgeons attending the American Society of ... eye surgeon Jeffrey L. Martin, MD will serve as ... is the Managing Partner of North Shore Eye Care. ... to lead this year’s discussion on the latest breakthroughs ...
(Date:4/18/2015)... 18, 2015 Thousand of DePuy Pinnacle ... of individuals who were allegedly harmed by a metal-on-metal ... forward in the U.S. District Court, Northern District of ... Court has amended an earlier Case Management Order to ... things, the new amendment permits the claims of up ...
Breaking Medicine News(10 mins):Health News:Lipitor Lawsuits Mount, as New Court Report Shows More Than 100 Filings Added to Federal Litigation Since March 2Health News:Lipitor Lawsuits Mount, as New Court Report Shows More Than 100 Filings Added to Federal Litigation Since March 3Health News:Lincoln, NE’s Bowling for Brains to benefit Renowned Brain Aneurysm Foundation 2Health News:Lincoln, NE’s Bowling for Brains to benefit Renowned Brain Aneurysm Foundation 3Health News:Auto Insurance Plans Can Cover Physical Injuries Caused By An Accident! 2Health News:Dr. Jeffrey Martin Invited to Share Latest Breakthroughs in Cataract Care During Roundtable Discussion at National 2015 ASCRS Meeting In San Diego 2Health News:DePuy Pinnacle Hip Lawsuits: Federal Litigation Amends Case Management Order to Allow for Joinder of Unrelated Claims 2Health News:DePuy Pinnacle Hip Lawsuits: Federal Litigation Amends Case Management Order to Allow for Joinder of Unrelated Claims 3
... 10, 2007 The sleep patterns of patients in ... barely spend any time in the restorative stages of ... physicians have found. , Current clinical-care protocols routinely and ... time when the need for adequate rest is perhaps ...
... Overall Survival Advantage in Elderly Myeloma ... Added to Standard Therapy - Data Presented at ... Dec. 9 Pharmion Corporation (Nasdaq:,PHRM) today announced final ... that the addition of,Thalidomide to standard treatment improves survival ...
... - Two drugs approved for use as second line therapy ... therapy for newly diagnosed patients in two clinical trials, research ... D. Anderson Cancer Center report at the 49th annual meeting ... patients in both trials have a complete cytogenetic response - ...
... Health & Science University Cancer Institute researchers have opened a ... , We are looking under the surface of CML to ... have discovered abnormal cells in the early stem cell population ... clone. These are abnormal cells that are not part of ...
... off going to the doctor or overindulge in unhealthy ... -- The holiday season is also the season for ... of the Vanderbilt Heart and Vascular Institute at Vanderbilt ... Churchwell, a look at a U.S. database of 53 ...
... GA, December 8, 2007 -- Results from two investigational ... bortezomib provide preliminary anti-tumor activity in patients with relapsed ... showed that 10 of 21 (48 percent) evaluable patients ... and bortezomib combination treatment. Data from a second ...
Cached Medicine News:Health News:Physicians seek to improve the quality of sleep in ICU, researchers at UT Southwestern report 2Health News:Thalidomide Added to Standard Therapy Prolongs Overall Survival in Newly Diagnosed Multiple Myeloma Patients Over Age 75 2Health News:Thalidomide Added to Standard Therapy Prolongs Overall Survival in Newly Diagnosed Multiple Myeloma Patients Over Age 75 3Health News:Thalidomide Added to Standard Therapy Prolongs Overall Survival in Newly Diagnosed Multiple Myeloma Patients Over Age 75 4Health News:Thalidomide Added to Standard Therapy Prolongs Overall Survival in Newly Diagnosed Multiple Myeloma Patients Over Age 75 5Health News:Thalidomide Added to Standard Therapy Prolongs Overall Survival in Newly Diagnosed Multiple Myeloma Patients Over Age 75 6Health News:Thalidomide Added to Standard Therapy Prolongs Overall Survival in Newly Diagnosed Multiple Myeloma Patients Over Age 75 7Health News:Dasatinib, Nilotinib show strong early results as frontline therapy for chronic myelogenous leukemia 2Health News:Dasatinib, Nilotinib show strong early results as frontline therapy for chronic myelogenous leukemia 3Health News:OHSU Cancer Institute research discovery opens new window to understanding chronic myeloid leukemia 2Health News:Heart Attacks Peak During the Holidays 2Health News:ZOLINZA (vorinostat) in combination with bortezomib demonstrated clinical activity 2Health News:ZOLINZA (vorinostat) in combination with bortezomib demonstrated clinical activity 3
(Date:4/17/2015)... 2015 Research and Markets ( ... "The Corporate Reputation of Pharma - The ... report to their offering. The ... now in its fourth edition. This report contains ... For each annual Corporate Reputation report, the author ...
(Date:4/16/2015)... , April 16, 2015 Vanda Pharmaceuticals Inc. ... on the development and commercialization of products for the ... will release results for the first quarter of 2015 ... The Company will host a conference ... 2015, during which Vanda management will discuss the first ...
(Date:4/16/2015)... 2015  Amgen (NASDAQ: AMGN ) today announced ... on Tuesday, April 21, 2015, after the close of ... by a conference call with the investment community at ... will be Robert A. Bradway , chairman and ... management team. Live audio of the conference ...
Breaking Medicine Technology:The Corporate Reputation of Pharma - The Global Patient Perspective in 2014 2Vanda Pharmaceuticals to Announce First Quarter 2015 Financial Results on May 6, 2015 2Amgen Announces Webcast Of 2015 First Quarter Financial Results 2
... SCOTTSDALE, Ariz., Feb. 14, 2012  Cayenne Medical, Inc., a ... of a $10 million equity financing, with new investor ... MB Venture Partners and Investor Growth Capital. The proceeds ... distribution and to support expansion of its portfolio of ...
... 2012 Leading events organiser UBM Live , a ... of Jim Buckley as the new Brand Director for Informex. ... value chemistry via a comprehensive calendar of conferences and events, ... is run in partnership with the Society of Chemical Manufacturers ...
Cached Medicine Technology:Cayenne Medical Closes $10 Million Capital Raise 2UBM Live Appoints Jim Buckley as Informex Brand Director 2UBM Live Appoints Jim Buckley as Informex Brand Director 3
... drainage from the ureteropelvic junction to the ... segment with no sideports prevents postoperative narrowing ... of the ureteral wall to the stent. ... one-time use. CAUTION: Periodic evaluation is advised; ...
... Whether you prefer silicone or ... Specialty Stents help promote healing after ... guards against anastomotic stricture, supports the ... the prevention of postoperative leakage. Following ...
... The Max-Blade™ Coagulating Resector is a device that ... This patented design was developed to provide the ... same high quality pathology chip, the approximate speed ... enjoyed with a standard loop but with ...
... Used for stone manipulation and removal in ... the basket to retain its shape following extreme ... stone capture by allowing the basket to open ... the stone. The tipless design reduces the likelihood ...
Medicine Products: