Navigation Links
2-drug combo more effective in treating sarcomas, Moffitt Cancer Center study shows
Date:4/9/2013

tudies on sarcomas-related mutations, such as the p53 gene. They also showed that MK-1775 was an active inhibitor of Wee1 regardless of the p53 mutation status of the tumors in the cell lines tested.

"The toxic effect of Wee1 inhibition on sarcoma cells appeared to be independent of p53 mutation status following our testing sarcoma cell lines with different p53 mutations," Altiok said. "All of them were highly sensitive to MK-1775, suggesting that Wee1 inhibition may represent a novel approach in the treatment of sarcomas. But p53 status was not predictive of response to MK-1775 as a single agent."

Because of the success of that previous research, in the new study the Moffitt team investigated the benefits of MK-1775 alone compared to MK-1775 in combination with gemcitabine, a standard chemotherapy drug. They tested the combination in a number of sarcoma cell lines derived from patient tissues and then in animals modeled with osteosarcoma (bone sarcoma).

"The combination of MK-1775 and gemcitabine demonstrated a synergistic effect in sarcoma cells," explained Altiok. "MK-1775 alone caused tumor cell damage, but when used in combination with gemcitabine, there was increased cell death."

When the research team tested the combination in laboratory animals, they found that gemcitabine alone inhibited 40 percent of tumor growth. MK-1775 alone inhibited 50 percent of tumor growth. However, MK-1775 and gemcitabine together inhibited 70 percent of tumor cell growth.

"Our data demonstrated that MK-1775 alone and in combination with gemcitabine induces significant cell death in high-grade osteosarcoma cells," concluded the authors. "This finding lays an important foundation for future clinical trials with MK-1775, which is a well-tolerated, readily available targeted drug."


'/>"/>

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Some patients with incurable tumors and BRCA mutations respond to new 2-drug combination
2. Mayo Clinic: 2-drug combination may slow deadly thyroid cancer
3. Moffitt researcher investigates 2-drug synergy to treat drug-resistant chronic myeloid leukemia
4. Combo Therapy Helps Knock Out Fungal Meningitis
5. E-commerce Software Provider Shopping Cart Elite Launches “Combo” Feature.
6. Study Examines Combo Chin, Nose Plastic Surgery
7. Combo Treatment Might Beat Epidural to Ease Labor: Study
8. Combo Inhaler May Give Better Relief for Some With Asthma
9. Niacin-Statin Combo May Cause Side Effects for Heart Patients
10. Acai Plus & Detox Plus Combo Pack Now Comes with Extra Information Guide with Every Purchase
11. Combo of Avastin, second drug shows promise fighting brain cancer, Mayo Clinic finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... The festival season is coming soon. The high-end fashion designer ... cocktail dresses . A lot of sophisticated women like its ... new promotion for its high quality clothes. Now, each of ... 20 to 71 percent off. , The company’s cocktail ... provided in many fashionable colors. Mary, the company’s sales manager, ...
(Date:9/20/2014)... September 20, 2014 Recently, Best ... site, has launched its new website. The new ... of popular hosting products for customers. Here, people ... make a purchasing decision. Also, it has recommended ... , One of the great web hosting ...
(Date:9/20/2014)... September 20, 2014 Plumbing construction ... out of 5, indicating a moderately favorable purchasing environment ... score reflects current and future pricing trends that will ... prices. Other factors that negatively affect buyer power are ... construction and the moderate switching costs. Buyers benefit, however, ...
(Date:9/20/2014)... 20, 2014 The Arizona Advanced ... is celebrating National Manufacturing Day by opening its doors ... processing and additive manufacturing labs will be offered between ... at MCC’s Southern and Dobson campus (1833 W. Southern ... Lot D. , The AzAMI at MCC was established ...
(Date:9/19/2014)... (PRWEB) September 20, 2014 Nearly 780 ... of Common Pleas where a meeting took place to ... complaints pending in the court’s mass tort program. ... meet this past week at the Complex Litigation Center ... consolidated for pretrial proceedings. The Risperdal lawsuits filed against ...
Breaking Medicine News(10 mins):Health News:High-end Fashion Designer BellasDress Offers Luxurious Cocktail Dresses For Sophisticated Women 2Health News:Best Cheap Hosting USA Launches Its New Website And Recommends InMotion To Worldwide People 2Health News:Plumbing Construction Services Procurement Category Market Research Report from IBISWorld Has Been Updated 2Health News:Plumbing Construction Services Procurement Category Market Research Report from IBISWorld Has Been Updated 3Health News:Plumbing Construction Services Procurement Category Market Research Report from IBISWorld Has Been Updated 4Health News:National Manufacturing Day Open House at Mesa Community College Oct. 3 2Health News:Risperdal Lawsuits Move Forward As Attorneys Meet To Discuss Litigation, Reports Wright & Schulte LLC 2Health News:Risperdal Lawsuits Move Forward As Attorneys Meet To Discuss Litigation, Reports Wright & Schulte LLC 3Health News:Risperdal Lawsuits Move Forward As Attorneys Meet To Discuss Litigation, Reports Wright & Schulte LLC 4
... the future may be painless and noninvasive, thanks to smart ... test for skin cancer, patients today must endure doctors cutting ... lab and anxiously awaiting the results. Using laser microscopes that ... have the tools to painlessly scan a patient,s troublesome mole ...
... have discovered a signaling pathway that is crucial to ... data, obtained from cells, animals and ALI patients, suggest ... the targets significantly reduced flooding of the lungs that ... is a devastating disease, with 40 percent mortality and ...
... Researchers at Memorial Sloan-Kettering Cancer Center,s Nanotechnology ... Hybrid Silica Technologies, have received approval for their ... US Food and Drug Administration (FDA) for an ... imaging of cancer, which may be useful for ...
... a patient,s immune system and enables them to fight the ... first time in the UK. The treatment will use ... of Southampton, which will treat a selected group of volunteers ... forms of bone marrow and blood cancer. Scientists ...
... MONDAY, Jan. 31 (HealthDay News) -- A man is much more ... another woman than a girlfriend who had sex with another man, ... to stick with a man who had sex with another woman ... The findings provide new insight into the general male desire to ...
... Sprint Fidelis implantable cardioverter-defibrillator (ICD) leads (Medtronic) failed more ... heart disease, according to a multicenter study published online ... that lead failure was not associated with death or ... the patients whose leads fractured experienced painful inappropriate shocks, ...
Cached Medicine News:Health News:Smart lasers could make cancer biopsies painless, help speed new drugs to market 2Health News:Researchers discover signaling pathway crucial to acute lung injury 2Health News:Cancer-targeting investigational nanoparticle receives FDA IND approval for first-in-human trial 2Health News:Cancer-targeting investigational nanoparticle receives FDA IND approval for first-in-human trial 3Health News:Southampton scientists begin patient trials of new leukemia cancer vaccine 2Health News:Southampton scientists begin patient trials of new leukemia cancer vaccine 3Health News:Recalled ICD leads fail in women, youths most often 2
(Date:9/19/2014)... , Sept. 19, 2014 Kiromic, LLC, a ... of Kent Hance , the former chancellor of Texas ... retired as chancellor in July 2014, after raising $1.2 billion ... that Kent Hance , the most successful chancellor in ... team not only as an investor, but also as our ...
(Date:9/19/2014)... TRIANGLE PARK, N.C. , Sept. 19, 2014 ... focused on cloud-based drug design and development, partnering ... The company,s mission is to design new drugs ... 1 and 2 partners to further their development. ... its portfolio investments. To support this business model, ...
(Date:9/19/2014)... Sept. 19, 2014 Merck (NYSE: MRK ), ... and Canada , is teaming with celebrity chef ... Logra Tus Metas , an educational program encouraging Hispanics with type ... a key treatment goal to help reduce the risk of serious ... are at a higher risk for developing type 2 diabetes than ...
Breaking Medicine Technology:Former Texas Tech Chancellor Named New Vice Chairman of the Board of Kiromic, LLC 2Cloud Pharmaceuticals Announces Partnering Sessions and Presentation Schedule 2Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 2Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 3Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 4Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 5
... , Medicated, oil claiming to treat multitude of ailments is potentially toxic ... SILVER SPRING, ... Administration today warned consumers not to purchase or use a product called ... Flecha" (Spanish) or Mandarin. The product is potentially toxic and contains two ...
... , WILLIAMSVILLE, N.Y. , May 27 ... with the partnership of Simulated Surgical Systems, LLC (SSS) and ... College , Weill Cornell Medical Center , Vattikuti ... of Medicine & Dentistry at Robert Wood Johnson Medical School ...
Cached Medicine Technology:FDA Warning: Consumers Advised Not to Use Arrow Brand Medicated Oil & - Embrocation or Aceite Medicinal La Flecha 2Simulated Surgical Systems, LLC Partners to Bring Simulation Advances to Surgical Training 2Simulated Surgical Systems, LLC Partners to Bring Simulation Advances to Surgical Training 3
... The Coude tip design facilitates ... is available in a medium length ... drainage eye. The red latex construction ... catheter is also available in a ...
The BARDEX I.C. Catheter represents Bard's newest technology in providing protection against NUTI....
BARDEX Red Rubber Urethral Catheter (Robinson Model)...
Used to provide bladder drainage by percutaneous placement of a Malecot catheter. Supplied sterile in peel-open packages. Intended for one-time use....
Medicine Products: