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2 Mutations Were Critical to Spread of 1918 Flu
Date:2/19/2008

ains), researchers had earlier found that the pandemic virus transmitted efficiently between ferrets, while the NY18 strain proved only slightly infectious and AV18 not at all infectious.

While slightly infectious NY18 binded to the umbrella-shaped glycan receptors, it did not do it as well as the highly infectious pandemic strain did. The non-infectious AV18 strain had no affinity for the receptors.

Another strain, TX18, proved much more infectious than NY18, and it bonded with high affinity to the umbrella-shaped receptors.

Researchers from the Centers for Disease Control and Prevention reported on the infectiousness of these strains last year, but the MIT study is the first to explain the biochemical reason causing these differences.

More information

The U.S. Centers for Disease Control and Prevention has more about influenza.



-- Kevin McKeever



SOURCE: Massachusetts Institute of Technology, news release, Feb. 18, 2008


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