Navigation Links
2 Markers Predict Survival Odds in Colon Cancer Patients
Date:12/11/2008

One protein was protective, the other not, researchers found

THURSDAY, Dec. 11 (HealthDay News) -- Blood levels of two insulin-related proteins are able to predict which patients with colon cancer are most likely to die of their disease, new research suggests.

Insulin ushers blood sugar out of the bloodstream and into cells. The hormone tends to work less efficiently in people who are obese, eat heavily and don't exercise, a condition which can lead to diabetes, heart disease and other conditions.

This may explain why individuals who are obese, eat a "Western-style" diet that is high in fat, and low in fruits and vegetables, and are inactive are more likely to develop colon cancer and to have their tumors recur after surgery.

Conversely, colon cancer patients who eat a diet rich in fruits, vegetables, poultry and fish can significantly lower the risk of their cancer returning.

"This gave us further evidence that really lifestyle factors do seem to play a part in the risk of recurrence. This is another piece of the puzzle," said Dr. Brian M. Wolpin, an attending physician in medical oncology at Dana-Farber Cancer Institute and an instructor of medicine at Harvard Medical School, both in Boston. "Although this study doesn't demonstrate causation, it does start to get at the pathways that might be involved, what proteins might be involved in risk."

Wolpin was lead author of the study, published in the Dec. 5 issue of the Journal of Clinical Oncology.

"The magnitude of the benefit for exercise [in preventing recurrences] is on the same order as what we see with chemotherapy," added Dr. John Marshall, chief of hematology/oncology at Georgetown's Lombardi Comprehensive Cancer Center, in Washington, D.C. "This study is trying to find out what the science is behind that. It's not an answer. It's a lead."

Previous studies have shown that women with early breast cancer and high levels of insulin and C-peptide along with metabolic syndrome are more likely to see a recurrence of their disease and to die.

And laboratory studies had shown that insulin spurs growth of colorectal cancer cells, while IGFBP-1 inhibits their growth and spread.

This latest study involved 373 patients with non-metastatic (stage I-III) colorectal cancer diagnosed between 1991 and 2004.

Researchers looked at four proteins known to have a relationship to lifestyle factors, two with a stronger association and two with a lesser association. The two with the stronger association, one harmful (C-peptide) and one protective (IGFBP-1), turned out to be key.

Participants who had the highest levels of circulating IGFBP-1 had about a 50 percent reduced risk of dying, both overall and from colon cancer, compared with those who had the lowest levels of the protein, Wolpin said.

Meanwhile, those with the highest levels of plasma C-peptide had an 87 percent greater chance of dying overall and a 50 percent greater chance of dying from colon cancer than those with the lowest levels. The difference may be due to the fact that "C-peptide is basically insulin . . . and insulin clearly is correlated with heart disease and other things," Wolpin said.

"It doesn't mean we're going to give you a pill rather than tell you to exercise," Marshall said. "Instead of drug companies doing clinical trials, Nike should do them."

More information

The American Cancer Society has more on risk factors for colon cancer.



SOURCES: John Marshall, M.D., chief, hematology/oncology, Georgetown's Lombardi Comprehensive Cancer Center, Washington, D.C.; Brian M. Wolpin, M.D., instructor, medicine, Harvard Medical School, attending physician, medical oncology, Dana-Farber Cancer Institute, Boston; Dec. 8, 2008, Journal of Clinical Oncology, online


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. PreMD Files Provisional Patent Application Describing a New Method of Quantifying Cancer Biomarkers
2. Genetic Markers Identified for Alcohol Response in UCSF Gallo Study
3. Researchers ID Genetic Markers for Esophageal Cancer
4. New research finds markers for esophageal cancer before it develops
5. Morria Biopharmaceuticals Plc Announces Preliminary Results Regarding Inflammatory Markers From its Phase II Study in Allergic Rhinitis
6. Candidate markers for gastric cancer
7. Latest Pistachio Study Reveals Significant Reduction in Markers of Inflammation - an Emerging Risk Factor in Heart Disease
8. NIAID awards contracts to search for protein markers of disease
9. Simple, inexpensive and objective tools for the assessment of mucosal inflammation: fecal markers
10. Biomarkers May Help Spot, Track Alzheimers
11. Toyota Tsusho America, Inc. and Nippon Kayaku Co., Ltd. Announce the Formation of GlycoMark, Inc., a Joint Venture to Develop and Commercialize Novel Biomarkers for Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
2 Markers Predict Survival Odds in Colon Cancer Patients
(Date:2/12/2016)... ... 2016 , ... Itopia, a leader in cloud services automation ... Platform (CIP) into Cielo®, a discovery, migration and cloud orchestration engine. This integration ... and medium business (SMB) clients. , In recent years, BI and ...
(Date:2/12/2016)... ... February 12, 2016 , ... Fisher House Foundation Chairman and CEO Kenneth ... Nevada Military Support Alliance president Scott Bensing, and Peggy Kearns Director, VA Southern Nevada ... Healthcare System. This will be the first Fisher House in Nevada, and will ...
(Date:2/12/2016)... ... February 12, 2016 , ... The Jones Agency, a family ... eastern Texas, is launching a cooperative charity drive with the Tarrant Area Food Bank ... than 50,000 individuals and families in need, the Tarrant County Food Bank offers hope ...
(Date:2/12/2016)... ... February 12, 2016 , ... Erlanger Agency has announced a new partnership ... The latest campaign focuses on the fight against breast cancer, fundraising for a local ... here . , Carmen is a loving single mother of two boys who ...
(Date:2/12/2016)... ... 2016 , ... Donor Network West, the organ procurement organization that heals lives ... San Ramon Regional Medical Center. Under the collaboration, the first of its kind, specific ... a more certain time frame for donor families for the recovery of organs. ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Stem cells are primitive cells found in ... the capacity to differentiate into mature cell types Stem ... first mouse embryonic stem cells were derived from embryos ... the first culturing of embryonic stem cells from non-human ... until 2006 As a result of these discoveries, stem ...
(Date:2/11/2016)... Feb. 11, 2016  Governor Andrew M. Cuomo today ... 1,400 jobs throughout Western New York ... the SUNY Polytechnic Institute, includes a major expansion of ... Buffalo , as well as the ... in Dunkirk . The combined projects ...
(Date:2/11/2016)... , Feb. 11, 2016 AAIPharma ... provider of custom manufacturing and development services for ... sterile fill-finish capabilities and capacity in its ... in demand has driven several recent investments. ... it had one filling line with small-scale lyophilization. ...
Breaking Medicine Technology: