Navigation Links
1st Artificial Windpipe Made With Stem Cells Seems Successful
Date:11/24/2011

WEDNESDAY, Nov. 23 (HealthDay News) -- A 36-year-old husband and father of two children with an inoperable tumor in his trachea (windpipe) has received the world's first artificial trachea made with stem cells.

A report published online Nov. 23 in The Lancet described the transplant surgery, which was performed in June at the Karolinska University Hospital in Stockholm, Sweden.

Without the transplant, the authors of the report explained, the man from Reykjavik, Iceland would have died. A golf ball-sized tumor on his trachea had begun to restrict his breathing. In a 12-hour procedure, doctors completely removed the affected area of his trachea and replaced it with an artificial one.

The artificial trachea was custom-made using three-dimensional imaging. First, a glass model was built to help shape an artificial scaffold. Stem cells were then inserted into the scaffold to create a functioning airway, the authors explained in a journal news release.

The scientists said their technique is an improvement over other methods because they used the patient's own cells to create the airway so there is no risk of rejection and the patient does not have to take immunosuppressive drugs.

In addition, they noted, because the trachea was custom-made it would be an ideal fit for the patient's body size and shape, and would eliminate the need to remain on a waiting list for a human donor.

"The patient has been doing great for the last four months and has been able to live a normal life. After arriving in Iceland at the start of July, he was one month in hospital and another month in a rehabilitation center," a co-author of the study and the physician who referred the patient for the procedure, Tomas Gudbjartsson, of Landspitali University Hospital and University of Iceland, Reykjavik, said in the news release.

The transplant team has since performed another transplant on a second patient from Maryland with cancer of the airway. This patient's bioartificial scaffold, however, was made from nanofibers. They now hope to treat a 13-month-old South Korean infant also using this method.

"We will continue to improve the regenerative medicine approaches for transplanting the windpipe and extend it to the lungs, heart and esophagus. And investigate whether cell therapy could be applied to irreversible diseases of the major airways and lungs," said Gudbjartsson.

Although the technique shows promise, Dr. Harald C. Ott and Dr. Douglas J. Mathisen, from Massachusetts General Hospital and Harvard Medical School in Boston, cautioned that more research must to be done to fully evaluate its safety and effectiveness.

"To be adjudged successful, bioartificial organs must function over a long time -- short-term clinical function is an important achievement, but is only one measure of success. Choice of ideal scaffold material, optimum cell source, well-defined tissue culture conditions, and perioperative management pose several questions to be answered before the line to broader clinical application of any bioartificial graft can be crossed safely and confidently," Ott and Mathisen concluded in the news release.

More information

The U.S. National Institutes of Health has more about stem cells.

-- Mary Elizabeth Dallas

SOURCE: The Lancet, news release, Nov. 23, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Radiation boost for artificial joints
2. New use of artificial lung device pioneered at University of Kentucky
3. Related studies point to the illusion of the artificial
4. Artificial light quality affects herbivore preference for seedlings
5. Washington University surgeons successfully use artificial lung in toddler
6. 2-year results: Artificial disc a viable alternative to fusion for 2-level disc disease
7. Artificial tissue promotes skin growth in wounds
8. Latest Artificial Pancreas Trials Reduce Risk of Low Blood Sugar
9. University of Granada researchers make the first bioartificial organ in Spain
10. For back, neck pain, artificial disc replacement has cost, outcome advantages over fusion surgery
11. Biological joints could replace artificial joints soon
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
1st Artificial Windpipe Made With Stem Cells Seems Successful 
(Date:1/18/2017)... ... January 18, 2017 , ... ... development solutions for drugs, biologics and consumer health products, today announced that Mr. ... at the upcoming WCBP Conference, to be held at the Mayflower Hotel, Washington ...
(Date:1/18/2017)... ... January 18, 2017 , ... The Hear ... aid project with the donation of cochlear implants. In February 2017, the first ... thus a fair chance of leading an independent life. This engagement builds on ...
(Date:1/18/2017)... ... January 18, 2017 , ... During pregnancy, women are at ... and those dental problems can increase the risk of pregnancy complications. Unfortunately, according ... failing to get the dental care they need. Agoura Hills dentist, Philip Shindler ...
(Date:1/17/2017)... ... January 17, 2017 , ... January is National Stalking Awareness Month (NSAM), now in ... the corners and commit the crime of stalking, a very real danger to many in ... overlooked factor in stalking and other crimes. , “Stalking: know it. Name it. Stop it.”—so ...
(Date:1/17/2017)... ... 17, 2017 , ... Gym Source, America’s leading retailer of premium residential and ... Hwy in Miami, FL. , “We are elated to be opening this new showroom,” ... is designed to give clients a seamless and motivating shopping experience.” , Every fitness ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... Food and Drug Administration CSL CureVac ... and Drug Administration FORT Fresenius Pharmaceuticals ... Klein GlaxoWellcome Global Influenza Programme Grippol ... Immune Targeting Systems Indian Association of Paediatrics Janssen ... Johnson Krka Pharmaceuticals Medicago Medicare ...
(Date:1/17/2017)... -- North America Insulin Delivery Market Outlook to 2022 ... Delivery Market Outlook to 2022", provides key market data ... provides value, in millions of US dollars, volume (in ... Insulin Pens, Insulin Pumps, Insulin Syringes and Traditional Insulin ... and distribution shares data for each of these market ...
(Date:1/17/2017)... , Jan 17, 2017 Research and Markets ... System Market 2016-2020" report to their offering. ... The global artificial pancreas devices ... period 2016-2020. Global Artificial Pancreas Devices System Market 2016-2020, ... from industry experts. The report covers the market landscape and its ...
Breaking Medicine Technology: