Navigation Links
1st Artificial Windpipe Made With Stem Cells Seems Successful
Date:11/24/2011

WEDNESDAY, Nov. 23 (HealthDay News) -- A 36-year-old husband and father of two children with an inoperable tumor in his trachea (windpipe) has received the world's first artificial trachea made with stem cells.

A report published online Nov. 23 in The Lancet described the transplant surgery, which was performed in June at the Karolinska University Hospital in Stockholm, Sweden.

Without the transplant, the authors of the report explained, the man from Reykjavik, Iceland would have died. A golf ball-sized tumor on his trachea had begun to restrict his breathing. In a 12-hour procedure, doctors completely removed the affected area of his trachea and replaced it with an artificial one.

The artificial trachea was custom-made using three-dimensional imaging. First, a glass model was built to help shape an artificial scaffold. Stem cells were then inserted into the scaffold to create a functioning airway, the authors explained in a journal news release.

The scientists said their technique is an improvement over other methods because they used the patient's own cells to create the airway so there is no risk of rejection and the patient does not have to take immunosuppressive drugs.

In addition, they noted, because the trachea was custom-made it would be an ideal fit for the patient's body size and shape, and would eliminate the need to remain on a waiting list for a human donor.

"The patient has been doing great for the last four months and has been able to live a normal life. After arriving in Iceland at the start of July, he was one month in hospital and another month in a rehabilitation center," a co-author of the study and the physician who referred the patient for the procedure, Tomas Gudbjartsson, of Landspitali University Hospital and University of Iceland, Reykjavik, said in the news release.

The transplant team has since performed another transplant on a second patient from Maryland with cancer of the airway. This patient's bioartificial scaffold, however, was made from nanofibers. They now hope to treat a 13-month-old South Korean infant also using this method.

"We will continue to improve the regenerative medicine approaches for transplanting the windpipe and extend it to the lungs, heart and esophagus. And investigate whether cell therapy could be applied to irreversible diseases of the major airways and lungs," said Gudbjartsson.

Although the technique shows promise, Dr. Harald C. Ott and Dr. Douglas J. Mathisen, from Massachusetts General Hospital and Harvard Medical School in Boston, cautioned that more research must to be done to fully evaluate its safety and effectiveness.

"To be adjudged successful, bioartificial organs must function over a long time -- short-term clinical function is an important achievement, but is only one measure of success. Choice of ideal scaffold material, optimum cell source, well-defined tissue culture conditions, and perioperative management pose several questions to be answered before the line to broader clinical application of any bioartificial graft can be crossed safely and confidently," Ott and Mathisen concluded in the news release.

More information

The U.S. National Institutes of Health has more about stem cells.

-- Mary Elizabeth Dallas

SOURCE: The Lancet, news release, Nov. 23, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Radiation boost for artificial joints
2. New use of artificial lung device pioneered at University of Kentucky
3. Related studies point to the illusion of the artificial
4. Artificial light quality affects herbivore preference for seedlings
5. Washington University surgeons successfully use artificial lung in toddler
6. 2-year results: Artificial disc a viable alternative to fusion for 2-level disc disease
7. Artificial tissue promotes skin growth in wounds
8. Latest Artificial Pancreas Trials Reduce Risk of Low Blood Sugar
9. University of Granada researchers make the first bioartificial organ in Spain
10. For back, neck pain, artificial disc replacement has cost, outcome advantages over fusion surgery
11. Biological joints could replace artificial joints soon
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
1st Artificial Windpipe Made With Stem Cells Seems Successful 
(Date:2/5/2016)... Chicago, Illinois (PRWEB) , ... February 05, 2016 ... ... advisors and independent PROSHRED franchises from across the country gathered at the La ... to recognize top performers. PROSHRED Chicago was named the year’s most outstanding ...
(Date:2/5/2016)... ... 05, 2016 , ... Boar’s Head Brand®, one of the nation’s leading providers ... Game. Take the stress out of your party preparation – follow these easy, yet ... stage of the game. , “The key to hosting a successful game-day party is ...
(Date:2/5/2016)... ... 05, 2016 , ... Stuart Bentkover, MD, FACS is thrilled to ... the most effective tattoo removal today, Dr. Bentkover is the only doctor in Central ... the PicoSure has been approved by the Food and Drug Administration (FDA) as a ...
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... Health and ... more relevant to individuals in the event they are experiencing an illness. Migraines are ... Those Americans that are afflicted with migraines would not wish the pain on their ...
(Date:2/5/2016)... ... 2016 , ... KICVentures ( http://www.kicventures.com ) announced today that ... York City on Thursday, January 21, 2016. Kingsley R. Chin, the CEO ... the varsity Columbia soccer program) spoke at the event, offering professional insight based ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... Calif. , Feb. 5, 2016  Syneron ... global aesthetic device company, announced today that ... Candela North America, is scheduled to participate in ... Healthcare Conference on February 11, 2016 in ... will allow institutional investors to meet with the ...
(Date:2/5/2016)... 5, 2016  Patients in Alabama ... (HIFU) therapy no longer have to travel out of state. ... with Urology Centers of Alabama to provide a ... for qualifying patients. Alabama ... treatment of prostate cancer using many different modalities. They are ...
(Date:2/5/2016)... 5, 2016 Aethlon Medical, Inc. (Nasdaq: AEMD ... CEO, will be presenting at Source Capital Group,s 2016 Disruptive ... at 2:15 p.m. ET on Wednesday, February 10, ... discussion taking place at 3:15 p.m. ET. http://www.aethlonmedical.com ... hour after the conclusion of the live event. The panel ...
Breaking Medicine Technology: