Navigation Links
18F-DG PET/CT can highly increase the detection of colorectal cancer
Date:10/10/2007

Combined positron emission tomography and computed tomography (PET/CT) is currently widely used in the clinical diagnosis of cancer to provide functional and morphological imaging. The value of PET/CT in detection of the recurrence and metastasis of colorectal cancer (CRC) was recently confirmed in an article appearing in the October 7 issue of the World Journal of Gastroenterology.

The research performed at the Department of Medical Oncology, Jinling Hospital, China. Dr. Chen and his colleagues observed a total of 68 postoperative CRC patients, 48 male and 20 female, who were examined in the Jinling Hospital PET/CT Center between August 2004 and August 2006. After PET/CT imaging, recurrence and/or metastasis were confirmed in 82.4% (56/68) of the patients, with 91.7% (22/24) cases with elevated serum CEA levels. PET/CT detected more lesions than CT or ultrasonography alone in 30.4 % (17/56) of the cases of recurrence and/or metastasis.

CRC is the most common gastrointestinal malignancy, and its incidence and mortality are rising in China. Radical resection remains as the major means of CRC management, but recurrence and/or metastasis occurs in 30 to 50 percent of patients after surgery. An accurate diagnosis of postoperative local recurrence and distant metastasis is crucial for prescribing optimal individualized management and thus elevating the survival rate. However, CRC is not normally detected by traditional imaging techniques, such as CT, magnetic resonance imaging (MRI) and ultrasonography, until the lesion reaches a considerable size.

PET/CT imaging provides a whole-body overview in one examination, and can detect abnormal glucose metabolism before the morphological changes of a lesion can be identified. In the current study, the treatment plans of 16.2% (11/68) of the cases were altered based on the PET/CT findings. Local metastasis focus was detected in the liver or lung in three cases; accordingly surgical resections were conducted instead of intravenous chemotherapy. Conversely, disseminated metastases were detected in six cases, and thus intravenous or oral chemotherapy was prescribed instead of surgery.

To most CRC patients, the cost of PET/CT is more expensive than traditional imaging techniques. However, Dr. Chen believes an optimal, individualized treatment plan is the most important aspect of treating this malignancy, as such a plan can indeed prolong the life and lessen both the mental and economical burdens of patients.

The researchers demonstrated the superiority of 18F-DG PET/CT in the imaging diagnosis of the postoperative recurrence and/or metastasis of CRC by conducting a retrospective study of 68 patients. Their findings are valuable when considering the choice of imaging techniques for detecting the recurrence and/or metastasis of CRC.


'/>"/>

Contact: You-De Chang
y.d.chang@wjgnet.com
86-108-538-1892
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. PET/CT: The Best Test for Women With Ovarian Cancer
2. MRI with nanoparticles highly sensitive in detecting prostate cancer metastases
3. Highly Educated More Prone To Parkinsons Disease
4. Alzheimers Disease Progresses Rapidly In Highly Educated
5. Mapping Of Brain Highly Beneficial For Safer Brain Tumor Surgery
6. Highly Pure Form Of heroin Proving To be lethal Killer
7. Highly Potent TB Strain Plays Favorites Targeting Specific Ethnic Groups
8. Threat posed by highly resistant strains of TB
9. Highly-Concentrated Botulinum Preparation Can Result in Severe Illness
10. Therapy Modulates Highly Sensitized Immune System to Let Mother Give Kidney to Daughter
11. Act Now To Cleanse Highly Polluted River Hindon, Says Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... Dr. Bernie Siegel, ... seller "LOVE, MEDICINE and MIRACLES") addresses touchy topics related to Death live on ... . Dr. Bernie Siegel, author of a plethora of essential books-to-read for ...
(Date:4/29/2016)... ... April 29, 2016 , ... Coast Dental Fort Stewart ... at its new location in the Exchange Furniture Mall at 112 Vilseck Road in ... 50-inch Samsung Smart TV. Plus attendees will have the opportunity to meet general dentists ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... ... announced that student team BioCellection won the $30,000 Perlman Grand Prize of the 2016 ... the Gloeckner Undergraduate Award, the Michelson People‚Äôs Choice Award, and the Committee Award ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... ... the Canadian Celiac Association (CCA), is pleased to announce the launch of the ... products, nutritional articles, recipes, and more. The purpose of the GFCP Scoop ...
(Date:4/29/2016)... , ... April 29, 2016 , ... New York City based oral and maxillofacial surgeon ... is a very effective way to treat obstructive sleep apnea. Dr. Jamali is proud to ... is a procedure that involves one or both jaw bones. This surgery is performed to ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... ORANGE COUNTY, Calif. , April 29, 2016 ... technology industry is projected to shift from systems ... can replace all types of modality CRT Medical ... set-up." Although there are a host of foreseeable ... a serious concern; will existing modalities have to ...
(Date:4/29/2016)... April 29, 2016 ReportsnReports.com ... 2016" market research report that provides an overview ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ... reviews key players involved in the therapeutic development ...
(Date:4/29/2016)... April 29, 2016 Acquisition ... Sciences, Product Development Capabilities in North ... Base . Indegene ( http://www.indegene.com ... the acquisition of Skura Corporation,s life science business. ... adaptive sales enablement technology for life science organizations ...
Breaking Medicine Technology: